Metabolomics applied to emerging infectious diseases: Advancing biomarker discovery and characterising host-pathogen interaction in melioidosis and seps

应用于新发传染病的代谢组学：推进类鼻疽和脓毒症中生物标志物的发现并表征宿主与病原体的相互作用

• 批准号: nhmrc : 1026224
• 负责人: A/Pr Ganjana Lertmemongkolchai
• 金额: $ 28.02万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/metabolomics-applied-emerging-melioidosis-seps/110478
• 关键词: Metabolomics; applied; emerging; infectious; diseases

Melioidosis is an emerging disease in Australia and South-East Asia due to its association with diabetes and changing climate. The current clinical methods often fail to save the life of melioidosis patients who develop sepsis. This study will search for melioidosis metabolite biomarkers that help in rapid diagnosis and in selecting adequate treatment which is essential to reduce the mortality. Future, similar studies on other sepsis infections could improve clinical sepsis management world wide.

由于类鼻疽与糖尿病和气候变化有关，它是澳大利亚和东南亚的一种新疾病。目前的临床方法常常无法挽救脓毒症类鼻疽患者的生命。这项研究将寻找类鼻疽代谢生物标志物，以帮助快速诊断和选择适当的治疗方法，这对于降低死亡率至关重要。未来，对其他败血症感染的类似研究可以改善全世界的临床败血症管理。