Resolving sources of heterogeneity and comorbidity in alcohol use disorder

K.220.7: PROJECT SUMMARY/ABSTRACT Training: The major objectives of the proposed K99/R00 Pathway to Independence Award are Dr. Ashley Watts’ training in alcohol research and the launching of her career as an independent scientist. As a postdoctoral research fellow in the Department of Psychological Sciences at the University of Missouri, Dr. Watts is well along the path to becoming a leading psychopathology researcher. Dr. Watts seeks training and mentoring during the K99 phase to narrow her focus to alcohol use and alcohol use disorder and gain more training in quantitative genetics and modeling. Training in AUD will emphasize on AUD nosology; modern models of addiction, including their key neurobehavioral mechanisms; and individual differences in alcohol consumption. She will attend conferences related to alcohol use/misuse, behavior genetics, and psychopathology. She will also attend behavioral and molecular genetics workshops that span from human to animal models, as well as a neuroscience workshop; each of these workshops provides hands-on training in quantitative genetic techniques. This training will greatly extend Dr. Watts’ foundational knowledge and skill set. Dr. Watts will dedicate a great deal of her time to the dissemination of findings from the proposed research through manuscript preparation and submission. The proposed mentor and co-mentor (Drs. Kenneth Sher and Andrew Heath), collaborators (Drs. Wendy Slutske, Douglas Steinley, and Phillip Wood), and consultants (Drs. John Crabbe, Arpana Agrawal, Kathleen Bucholz, Kristina Jackson, and David Watson) collectively provide expertise that is ideally suited to facilitate the successful completion of the proposed training and research activities. Furthermore, the University of Missouri is a world-class research institution with the resources necessary to facilitate successful completion of the training (K99) phase of the proposed project. K99 Phase: With supervision, Dr. Watts will conduct secondary data analysis on phenotypic and genetic heterogeneity within AUD. This work will be achieved using a combination of large-scale cross-sectional and longitudinal phenotypic and genetically informative data. She will receive training via mentorship, coursework, workshops, readings, and consultation. R00 Phase: Dr. Watts will ascertain features of AUD that are specific to alcohol use, rather than general to substance use, externalizing psychopathology, or psychopathology more broadly using phenotypic, behavior genetic, and molecular genetic analysis. Significance: Her work will ultimately target sources of heterogeneity within AUD, characterize specific AUD vulnerabilities, and inform future precision-medicine efforts, each of which are emphasized by NIAAA’s emphases on the improvement of AUD diagnosis and understanding its relations with other forms of psychopathology (NIAAA, 2017).

K.220.7：项目摘要/摘要 培训：拟议的K99/R00独立奖的主要对象是Ashley Watts博士 酒精研究培训以及她作为独立科学家的职业生涯的培训。作为博士后 密苏里大学心理科学系研究员瓦茨博士很好 成为领先的心理病理学研究人员的途径。瓦茨博士在期间寻求培训和心理 K99阶段将其重点放在酒精使用和饮酒障碍上，并获得更多的定量培训 遗传学和建模。 AUD培训将强调AUD典型学；现代成瘾模式，包括 他们的关键神经行为机制；以及饮酒的个体差异。她会参加 与酒精使用/失误，行为遗传学和心理病理学有关的会议。她也会参加 从人到动物模型的行为和分子遗传学研讨会以及神经科学 车间;这些研讨会中的每一个都提供定量遗传技术的动手培训。这个培训 将大大扩展沃茨博士的基本知识和技能。瓦茨博士将奉献她的大量 是时候通过手稿准备从拟议的研究中传播发现的时间 提交。拟议的导师兼联合会（Dr. Kenneth Sher博士和Andrew Heath博士），合作者（博士。 Wendy Slutske，Douglas Steinley和Phillip Wood）以及顾问（John Crabbe博士，Arpana Agrawal， Kathleen Bucholz，Kristina Jackson和David Watson）共同提供了非常适合的专业知识 促进成功完成拟议的培训和研究活动。此外，大学 密苏里州是一家世界一流的研究机构，拥有促进成功完成所需的资源 拟议项目的培训（K99）阶段。 K99阶段：在监督下，Watts博士将对表型和遗传进行辅助数据分析 AUD内的异质性。这项工作将通过大规模横截面和 纵向表型和一般信息的数据。她将通过Mentalship，Lousswork， 讲习班，阅读和咨询。 R00阶段：Watts博士将确定特定于酒精的AUD特征，而不是一般 使用表型，行为更广泛地使用药物使用，心理病理学或心理病理学 遗传和分子遗传分析。 意义：她的工作最终将针对AUD内的异质性来源，以特定的AUD来表征 脆弱性，并告知未来的精密中等医学努力，每一种都由NIAAA强调 重点是改进AUD诊断及其与其他形式的关系 心理病理学（NIAAA，2017年）。