Sex differences in reward neurocircuitry underlying alcohol craving and consumption in trauma-exposed individuals

遭受创伤的个体对酒精的渴望和消费背后的奖赏神经回路的性别差异

• 批准号: 10785214
• 负责人: Cecilia A Hinojosa
• 金额: $ 13.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10785214
• 关键词: Alcohol consumption; Applications Grants; Award; Behavior; Bilateral; Biological; Black American; Brain; Clinic; Clinical; Collection; Complex; Consumption; Corpus striatum structure; Cross-Sectional Studies; Data; Data Analyses; Development; Diagnosis; Disease; Dopamine; Ecological momentary assessment; Educational workshop; Ensure; Epidemiology; Face; Faculty; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Health; Healthcare; Human; Individual; Knowledge; Laboratories; Learning; Maintenance; Measures; Mediating; Mediation; Mentors; Minority Groups; Minority Women; Modeling; National Institute of Mental Health; Neurologic; Nucleus Accumbens; Participant; Pathway interactions; Pattern; Persons; Physician Executives; Population; Positioning Attribute; Post-Traumatic Stress Disorders; Pre-Clinical Model; Predisposition; Prefrontal Cortex; Psychiatry; Publications; Research; Rewards; Role; Services; Severities; Sex Differences; Statistical Data Interpretation; Statistical Models; Students; Study Subject; Symptoms; Techniques; Testing; Training; Trauma; United States; United States National Institutes of Health; Universities; Woman; addiction; alcohol consequences; alcohol craving; alcohol effect; alcohol use disorder; dual diagnosis; empowerment; ethnic minority population; experience; human subject; meetings; men; mid-career faculty; multimodal neuroimaging; neural; neural circuit; neural correlate; neuroimaging; neuromechanism; neuropsychiatry; novel; post-trauma; preventive intervention; problem drinker; racial minority population; sex; skills; smartphone application; tenure track; trauma exposure; underrepresented minority student

PROJECT SUMMARY/ABSTRACT Candidate: My long-term goals are to acquire a tenure-track faculty position at a research-intensive university that serves students who reflect the diversity of the United States. My research will utilize multi-modal neuroimaging techniques to better understand the neural correlates and developmental relationship between posttraumatic stress disorder (PTSD) and alcohol use in women and racial/ethnic minority groups. I have a strong background in using structural and functional neuroimaging techniques to study the threat-related neurocircuitry related to the development and maintenance of PTSD. In this application, I propose to extend my training by first learning the basic neural mechanisms that promote alcohol use and how trauma exposure may contribute to neurological vulnerabilities in women, making this group more prone to using alcohol. Furthermore, I will build off the training I am already receiving through my Diversity Supplement award to learn how to use complex longitudinal statistical models to analyze ecological momentary assessment (EMA) data. Ultimately, this additional training will give me the skills to produce high-impact publications and successful R01 submissions. Training: In addition to Dr. Jennifer Stevens, I have a mentoring team filled with experts in academic research who will provide the necessary training and guidance to accomplish this proposal. Dr. Julie Kable is an Associate Professor of the Department of Psychiatry and Associate Director of the Emory Neurodevelopmental Exposure Clinic, Dr. Justine Welsh is an Associate Professor in the Department of Psychiatry and Director of the Emory Healthcare Addiction Services and Medical Director of the Addiction Alliance of Georgia, and Dr. Nicole Nugent is an Associate Professor at Brown University. Outside of the mentoring team, we have identified workshops, seminars, and meetings to provide further technical training, presentation experience, responsible conduct in research, and the necessary skills (negotiations, tenure, laboratory management) to transition to independence. Research: PTSD and alcohol use disorder (AUD) are highly co-occurring disorders (PTSD+AUD). Women are twice as likely than men to develop PTSD, and women face more detrimental health effects from alcohol compared to men. A large body of work has examined the neural mechanisms that underlie each disorder, separately. However, very few studies have examined the neural substrates of co-occurring PTSD+AUD, and none have examined sex differences. My preliminary data shows sex differences in the striatum, a region important in reward-related behavior. This proposal aims to define sex differences in reward-related neurocircuitry that contribute to alcohol use behaviors in trauma-exposed women. By using EMA and functional neuroimaging techniques, I anticipate expanding our understanding of sex differences in reward- related neurocircuitry that promote alcohol use in trauma-exposed populations. The successful completion of this proposed project has the potential to inform the development of preventative interventions to inhibit the development of AUD in trauma-exposed women.

项目摘要/摘要 候选人：我的长期目标是在一所研究密集于大学中获得终身任职教师职位 这为反映美国多样性的学生提供服务。我的研究将利用多模式 神经影像学技术可以更好地了解神经相关性和发展关系 创伤后应激障碍（PTSD）和种族/种族少数群体中的饮酒。我很强 使用结构和功能性神经影像学技术来研究与威胁相关的神经记录的背景 与PTSD的开发和维护有关。在此应用程序中，我建议将我的培训扩展到首先 学习促进饮酒的基本神经机制，以及创伤暴露如何有助于 女性的神经系统脆弱性使该群体更容易使用酒精。此外，我将建造 我已经通过我的多样性补充奖获得了培训，以学习如何使用复杂 纵向统计模型分析生态瞬时评估（EMA）数据。最终，这个 额外的培训将使我能够制作高影响力出版物和成功的R01提交的技能。 培训：除了詹妮弗·史蒂文斯（Jennifer Stevens）博士外，我还有一个教育团队，充满了学术研究专家 谁将提供必要的培训和指导来实现这一建议。朱莉·库布尔博士是一名同事 精神病学系教授兼埃默里神经发育暴露副主任 诊所，贾斯汀·威尔士（Justine Welsh）博士是精神病学系的副教授，埃默里（Emory）主任 医疗保健成瘾服务和佐治亚成瘾联盟的医疗总监和妮可·努金特（Nicole Nugent）博士 是布朗大学的副教授。在指导团队之外，我们已经确定了研讨会， 研讨会和会议，以提供进一步的技术培训，演示经验，负责任的行为 研究以及过渡到独立性的必要技能（谈判，任期，实验室管理）。 研究：PTSD和酒精使用障碍（AUD）是高度同时发生的疾病（PTSD+AUD）。女人是 发展PTSD的可能性是男性的两倍，而妇女面临对酒精的更有害健康影响 与男人相比。大量工作检查了每个疾病的神经机制， 分别地。但是，很少有研究检查了同时发生的PTSD+AUD的神经底物，以及 没有人检查过性别差异。我的初步数据显示了纹状体的性别差异 对于奖励相关的行为很重要。该建议旨在定义与奖励相关的性别差异 在暴露创伤的妇女中有助于饮酒行为的神经记录。通过使用EMA和 功能性神经影像学技术，我预计会扩大我们对奖励性别差异的理解 - 相关的神经循环，可促进暴露创伤的人群中的酒精使用。成功完成 该提议的项目有可能告知预防干预措施的发展，以抑制 在暴露于创伤的妇女中发展AUD。