Tissue and Animal Use

组织和动物使用

基本信息

批准号：
7937752
负责人：
MILTON W DATTA
金额：
$ 13.91万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7937752
关键词：
Animal Model Animals Antibodies Architecture Archives Area Autopsy Bioinformatics Biological Markers Biology Biopsy Specimen Breast CCNE1 gene Cancer Patient Cells Characteristics Clinical Collaborations Collection Colon Colon Carcinoma Computer software Core Facility Data Data Analyses Data Set Databases Department of Defense Diagnostic Dissection Epithelium Ethics Evaluation Fine needle aspiration biopsy Formalin Freezing Frozen Sections Gene Targeting Grant Health Insurance Portability and Accountability Act Hematoxylin and Eosin Staining Method Histologic Histopathology Human Image Imaging Techniques Kidney Lasers Link Maintenance Malignant neoplasm of prostate Metastatic Neoplasm to the Bone Microscope Morphology Nanotechnology Operative Surgical Procedures Outcome PO-1 Paraffin Embedding Pathologic Pathologist Pathology Patients Photography Preparation Primary Cell Cultures Process Production Prostate Quality Control Records Research Research Ethics Committees Research Personnel Resources Sampling Scientist Screening procedure Secure Serum Services Slide Specimen Specimen Handling Staining method Stains Therapeutic Tissue Banking Tissue Banks Tissue Microarray Tissues Toxic effect Toxicology Training Transgenic Mice Universities Validation animal resource animal tissue anticancer research base biocomputing candidate validation design digital imaging experience high throughput analysis nanotherapeutic programs prospective repository research study response tissue processing treatment response tumor tumor xenograft urologic

项目摘要

Summary This Core functions as the main repository for patient specimens and annotated data, and to support animal studies in the areas of animal surgery, necropsy, specimen processing, and histopathology. This core builds upon an existing collaborative base between tissue banking, histopathology and animal models at Emory University. Specifically, it capitalizes and builds upon two ongoing research programs, the existing Department of Defense Emory Prostate Cancer Research Center Core Facility and an NCI P-01 "Prostate Cancer Bone Metastasis: Biology and Targeting" (CA098912). The core features integrated human specimen and patient databases that allow project scientists to query specimen availability as well as deidentified patient data to design and request specimens. This is integrated with support for sample preparation and processing with a focus on specific pathology needs such as histopathologic interpretation, laser capture micrqdissection, and tissue microarray production. Since many of these support services directly overlap with services, needed for animal specimen analysis, these services are offered in a single integrated core. A similar architecture exists for the PO-1 grant mentioned above, also under the direction of Dr. Amin (Pathology) and Dr. Martin (Animal Models). In collaboration with these programs, this CCNE core will provide comprehensive support for both human and animal studies.

概括该核心是患者标本和注释数据的主要存储库，并支持动物在动物手术，死灵，标本加工和组织病理学领域进行的研究。此核心构建在Emory的组织库，组织病理学和动物模型之间的现有协作基础上大学。具体而言，它大写并建立在两个正在进行的研究计划的基础上，即现有的国防部Emory前列腺癌研究中心核心设施和NCI P-01“前列腺癌症骨转移：生物学和靶向”（CA098912）。核心特征综合人标本和患者数据库，允许项目科学家查询标本的可用性并被识别患者数据设计和请求标本。这与对样本的支持集成在一起准备和处理，专注于特定病理需求，例如组织病理学解释，激光捕获微序列和组织微阵列的产生。由于其中许多支持服务与动物标本分析所需的服务直接重叠，这些服务是在单个服务中提供的集成核心。上面提到的PO-1赠款也存在类似的架构，也在 Amin博士（病理）和Martin博士（动物模型）。与这些程序合作，此CCNE 核心将为人类和动物研究提供全面的支持。