CYCLOTRON AND RADIOCHEMISTRY SPECIALIZED RESOURCE

回旋加速器和放射化学专业资源

• 批准号: 7918209
• 负责人: NAGICHETTIAR SATYAMURTHY
• 金额: $ 4.88万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7918209
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C1.1.1. Introduction: The CRSR is a Core component of the NSBCC, the NCI UCLA-ICMIC, UCLA Institute for Molecular Medicine (IMED) and Crump Institute for Molecular Imaging. The prime objective of the CRSR is to provide positron emitting radioisotopes and radiolabeled PET probes and biomarkers for investigators in NSBCC, ICMIC, IMED and the Crump Institute. The core is directed by Dr. Satyamuthy. The CRSR was established in 1971 by the Department of Energy as a part of IMED. It currently houses two RDS -112 negative ion cyclotron (CTI, Knoxville, TN) systems that are supported with a wide array of target systems, semiautomated and automated systems producing various radiolabeled precursors for synthesizing molecular probes and biomarkers, and for producing final labeled products as discussed below in detail. The CRSR has more than enough capacity to meet the needs of NSBCC. It has been both scientifically profitable and personally rewarding for the CRSR staff to expand our interactions with the physical and biological sciences community at UCLA. With the NSBCC program, that extension will now include Caltech and ISB researchers. In fact, for some of the NSBCC Projects preliminary results were obtained through joint Caltech/UCLA collaborations. Approximately 10% of our radiosynthesis work over the initial NSBCC funding period will be NSCBB-related, with about 50% of the rest of the work supported by various other NCI supported research and educational programs as discussed in the proposal. In reality, the DoE support supplements, to some extent, programs that are under the aegis of the NSBCC.

C1.1.1。简介：CRSR是NSBCC，NCI UCLA-ICMIC，UCLA Institute的核心组成部分 用于分子医学（IMED）和Crump分子成像研究所。 CRSR的主要目标是 为研究人员提供推广放射性异位素和放射性标记的PET探针和生物标志物 NSBCC，ICMIC，IMED和Crump Institute。核心由Satyamuthy博士执导。 CRSR由能源部于1971年成立，作为IMED的一部分。目前有两个 RDS -112负离子转基因（CTI，诺克斯维尔，田纳西州诺克斯维尔）系统，这些系统受广泛的目标支持 系统，半小矩和自动化系统，产生各种放射性标记的前体，用于合成 分子探针和生物标志物，用于生产最终标记的产品，如下所述。这 CRSR具有足够的能力来满足NSBCC的需求。 对于CRSR员工而言，扩大我们的互动既是科学上的盈利，也是个人的回报 与加州大学洛杉矶分校的物理和生物科学社区。使用NSBCC程序，该扩展将 现在包括加州理工学院和ISB研究人员。实际上，对于一些NSBCC项目而言，初步结果是 通过Caltech/UCLA合作获得。 我们约有10％ 放射合成在 最初的NSBCC资金期将 与NSCBB有关，大约 其余工作的50％ 得到其他各种NCI的支持 支持研究和 教育计划 在提案中讨论。在 现实，美国能源部的支持 在某种程度上补充 计划 NSBCC的宙斯盾。