Comprehensive SDSU-UCSD Cancer Center Partnership (2 of 2)

全面的 SDSU-UCSD 癌症中心合作伙伴关系（2 of 2）

• 批准号: 7692914
• 负责人: ANA M NAVARRO
• 金额: $ 143.82万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7692914
• 关键词: Comprehensive; SDSU; UCSD; Cancer; Center

DESCRIPTION (provided by applicant):Significant advances in biotechnology and biochemistry have led to the discovery of a large number of cancer vaccines based on peptides and proteins. However, the development of suitable and efficient carrier systems remains a major challenge since the vaccine bioavailability is limited by enzymatic degradation. We developed recently several promising new vaccines for prostate cancer based on natural and modified survivin-derived peptides. We propose to encapsulate the survivin-derived peptide vaccines into our newly developed nanoparticles targeted to the mannose receptors on the dendritic cells. The inclusion of mannose or some of its derivatives in the nanoparticle formulation is expected to enhance delivery of active antigen and is the major conceptual advance of this pilot project. We suggest that this novel vaccine will induce potent and specific immune responses against prostate cancer. Because survivin is highly expressed in all prostate cancer, this new nanoparticle-vaccine strategy may have important clinical applications. This approach may provide a potential avenue for immunotherapy of prostate cancer, as many other prostate cancer-associated antigens have been described to date.

描述（由申请人提供）：生物技术和生物化学的重大进展导致基于肽和蛋白质发现了大量癌症疫苗。但是，由于疫苗生物利用度受酶促降解的限制，因此合适有效的载体系统的开发仍然是一个重大挑战。我们最近开发了几种基于天然和经过修改的Survivin衍生肽的前列腺癌的新疫苗。我们建议将源自生存的肽疫苗封装到针对树突状细胞上甘露糖受体的新开发的纳米颗粒中。预计将甘露糖或其某些衍生物纳入纳米颗粒制剂中有望增强活性抗原的递送，这是该试点项目的主要概念前进。我们建议这种新型疫苗将诱导针对前列腺癌的有效和特定的免疫反应。由于Survivin在所有前列腺癌中都高度表达，因此这种新的纳米粒子疫苗策略可能具有重要的临床应用。这种方法可以为前列腺癌免疫疗法提供潜在的途径，因为迄今为止已经描述了许多其他前列腺癌相关的抗原。