UC Davis Center for Laboratory Animal Science Building J1 Renovation and Upgrade

加州大学戴维斯分校实验动物科学中心J1楼改造升级

• 批准号: 7430509
• 负责人: Bennie I. Osburn
• 金额: $ 40.47万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-06 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7430509
• 关键词: Agriculture; Animal Housing; Animal Model; Animals; Arizona; Arthropod Vectors; Biological; Biological Sciences; Birds; California; Communicable Diseases; Containment; Core Facility; Development; Discipline; Ecology; Extramural Activities; Family Felidae; Funding; Funding Applicant; Grant; Hawaii; Health; Infection; Infectious Diseases Research; Institution; Laboratories; Laboratory Animal Science; Medicine; Modeling; Mus; Nevada; Productivity; Public Health; Research; Research Personnel; Site; Sterilization for infection control; System; Universities; Veterinary Medicine; Veterinary Schools; Wing; Work; college; human disease; in vivo; programs; transmission process; wasting

DESCRIPTION (provided by applicant): Funds from this program will be used to purchase two biological sterilization units (autoclaves) for the Center for Laboratory Animal Sciences (CLAS) J1 building at the University of California at Davis (UC Davis) - one for animal cage systems, the other for laboratory-generated wastes. Including the autoclaves in the animal-containment wing of the J1 facility is essential for animal biosafety level-3 (BSL-3) infectious-disease research. Studies involving in-vivo experimentation models will use the space for performing animal infections, and for holding infected avian, murine, alternative animal models (some as large as domestic felids), and experimental infection and transmission models with arthropod vectors (exposed to infected animals). Additionally, because UC Davis houses the animal core facility for the Pacific Southwestern Regional Center for Excellence (PSWRCE), the facility will be used by all of the participating institutions in California, Arizona, Nevada, and Hawaii. Due to facility deficiencies, much of the work that is currently funded through extramural grants is performed at remote sites, negatively impacting research productivity. If the campus had sufficient facilities, UC Davis investigators from the Schools of Veterinary Medicine and Medicine and the Colleges of Biological Sciences and Agriculture & Environmental Sciences would benefit from synergy of these animal health disciplines. Funds provided by this program will make the J1 facility functional for animal BSL-3 use, leading to the study of infectious disease, increased development of animal models of human disease, and other research of direct benefit to public health.

描述（由申请人提供）：该计划的资金将用于为加利福尼亚大学戴维斯大学（UC Davis）的实验室动物科学中心（CLAS）J1建筑物购买两个生物灭菌单元（高压灭菌）（一个用于动物笼子系统）的J1大楼，另一种用于实验室生成的废物。包括J1设施的动物范围内的高压棒在内，对于动物生物安全3级（BSL-3）感染性疾病研究至关重要。涉及体内实验模型的研究将使用该空间进行动物感染，并使用感染的禽类，鼠，替代动物模型（有些与家用felids一样大），以及具有节肢动物载体（暴露于感染动物）的实验感染和传播模型。此外，由于加州大学戴维斯分校（UC Davis）在太平洋西南地区卓越中心（PSWRCE）设有动物核心设施，因此该设施将由加利福尼亚，亚利桑那州，内华达州和夏威夷的所有参与机构使用。由于设施缺陷，目前通过壁外赠款资助的许多工作都在偏远的地点进行，从而对研究生产力产生负面影响。如果校园设有足够的设施，则来自兽医医学和医学学院以及生物科学与农业与环境科学学院的UC Davis研究人员将从这些动物健康学科的协同作用中受益。该计划提供的资金将使J1设施用于动物BSL-3的使用功能，从而导致研究传染病，增加人类疾病动物模型的发展以及对公共卫生的其他直接利益研究。