Extending a Caribbean Based Cohort to Promote US-Caribbean Comparisons to Facilitate Research Addressing Black Health Disparities

扩大加勒比地区的队列以促进美国与加勒比地区的比较，以促进解决黑人健康差异的研究

• 批准号: 9886085
• 负责人: Kimlin Tam Ashing
• 金额: $ 67.18万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9886085
• 关键词: Address; African; African American; African Caribbean; Area; Award; Behavioral; Behavioral Risk Factor Surveillance System; Biological; Cardiovascular Diseases; Caribbean region; Centers of Research Excellence; Chronic Disease; Cohort Studies; Collection; Community Health Nursing; Comparative Study; Country; Data; Data Analytics; Data Collection; Data Set; Delaware; Disease; Enrollment; Epidemiology; Feedback; Field Workers; Fox Chase Cancer Center; Future; Genomics; Goals; Health; Health Status; Healthcare; Healthcare Systems; Heterogeneity; Immigrant; Immigration; Incidence; Individual; Infrastructure; Interviewer; Jamaica; Jamaican; Life Style; Link; Longitudinal cohort; Malignant Neoplasms; Measures; Medical History; Methods; Minority; Morbidity - disease rate; Mouthwash; National Health and Nutrition Examination Survey; New Jersey; New York; Not Hispanic or Latino; Outcome; Participant; Persons; Philadelphia; Population; Premature Mortality; Prevalence; Questionnaires; Race; Research; Research Support; Resources; Risk Factors; Sampling; Secure; Specimen; Subgroup; Surveys; United States; United States National Institutes of Health; Universities; Urine; Variant; West Indies; base; burden of illness; cancer prevention; cancer risk; cardiometabolism; cardiovascular disorder prevention; cardiovascular disorder risk; cohort; comparative; data harmonization; data integration; data mining; data sharing; effectiveness evaluation; epidemiologic data; ethnic diversity; health disparity; instrument; metropolitan; mortality; population based; population health; programs; racial and ethnic; response; retention rate; sharing platform; surveillance study

PROJECT SUMMARY/ABSTRACT Fifty percent of Non-Hispanic Black immigrants in the United States (US) originate from the Caribbean. Thus the health of US and Caribbean populations are closely intertwined due to both regional proximity and the high volume of Caribbean immigration to the US3. US and Caribbean Blacks also share disease burden; cancer and cardiovascular disease (CVD) account for their greatest health disparities-- killing more Black individuals in the US and the Caribbean than any other ethnic/racial group. Yet, there is a paucity of cancer and CVD comparative research between the US-born Black American and African-Caribbean sub-groups. While the NIH has invested in studying US minority/immigrant populations, comparisons with Caribbean cohorts are needed to untangle the effect of biological, environmental, behavioral, and cultural health care system determinants of CVD and cancer risk and outcomes. In partnership with the University of the West Indies (UWI), the African Caribbean Cancer Consortium (AC3) is already making headway into expanding an existing population-based cohort for cancer and CVD research in Jamaica. The Jamaica Health and Lifestyle Survey (JHLS-III), conducted in 2016-17, is a national representative sample of over 3000 persons. The JHLS-III collected bio-specimens and epidemiological data on CVD, cancer, other chronic diseases and their risk factors, and medical history. To the best of our knowledge, there are no other nationally representative population-based cohorts in the Caribbean specifically targeting cancer combined with other chronic diseases. With an NCI-P20 award, the AC3, an NCI-Epidemiology and Genomics Research Program supported consortium at Fox Chase Cancer Center and UWI have established a Caribbean Regional Center of Research Excellence in Cardiometabolic Disease and Cancer. This proposal will be a natural extension of this project by expanding the JHLS-III and building the data mining, storage and analytics infrastructure needed to harness and share data from epidemiological measures and biospecimens to promote comparative research in cancer and cardiometabolic disease. This proposed infrastructure building project will harness and prepare multi-level data for future US-Caribbean comparative studies. We propose to optimize enrollment and retention of Caribbean nationals in cohort studies by (a) obtaining multi-stakeholder input and feedback from community health nurses/field workers and JHLS-III 2016/17 cohort participants to refine targeted enrollment and retention strategies; and (b) evaluating the effectiveness of this strategy relative to historical enrollment and retention rates. We will repurpose and expand the JHLS-III into a robust longitudinal cohort of 8,000 participants, collect and store biospecimens, socioecological and health status data in order to answer questions about NCD (i.e. cancer and CVD) risk and outcomes. We will establish a secure data integration and sharing platform that will enable linkages of the Jamaica cohort with the CAP3 study and other Caribbean and US-based cohorts, and conduct preliminary analytics for data verification and harmonization.

项目概要/摘要 美国 50% 的非西班牙裔黑人移民来自加勒比地区。因此 由于区域邻近和高风险，美国和加勒比地区人口的健康密切相关 加勒比地区向美国移民的数量3。美国和加勒比黑人也分担疾病负担；癌症和 心血管疾病（CVD）是他们最大的健康差异的原因——杀死了更多的黑人 美国和加勒比地区比任何其他民族/种族群体都要多。然而，癌症和心血管疾病的比较却很少 美国出生的美国黑人和非洲裔加勒比人亚群体之间的研究。虽然 NIH 已投资 在研究美国少数族裔/移民人口时，需要与加勒比人群进行比较，以理清问题的根源 生物、环境、行为和文化医疗保健系统决定因素对心血管疾病和癌症的影响 风险和结果。非洲加勒比癌症中心与西印度群岛大学 (UWI) 合作 联盟 (AC3) 已经在扩大现有的基于人群的癌症队列方面取得了进展 牙买加的 CVD 研究。牙买加健康和生活方式调查 (JHLS-III) 于 2016-17 年进行 全国代表性样本3000多人。 JHLS-III 收集了生物样本和流行病学样本 有关 CVD、癌症、其他慢性疾病及其危险因素以及病史的数据。尽我们最大的努力 据了解，加勒比地区没有其他具有全国代表性的人口群体 针对癌症与其他慢性疾病的结合。荣获 NCI-P20 奖项的 AC3（NCI 流行病学研究） 福克斯蔡斯癌症中心和西印度大学基因组学研究计划支持的联盟已经建立 加勒比地区心脏代谢疾病和癌症卓越研究中心。这个提议 通过扩展 JHLS-III 并构建数据挖掘、存储和 需要利用和共享流行病学测量和生物样本数据的分析基础设施 促进癌症和心脏代谢疾病的比较研究。此次拟议的基础设施建设 项目将为未来的美国-加勒比比较研究利用和准备多层次数据。我们建议 通过 (a) 获得多方利益相关者的支持，优化加勒比国民在队列研究中的注册和保留 社区卫生护士/现场工作人员和 JHLS-III 2016/17 队列参与者的意见和反馈 完善有针对性的招生和保留策略； (b) 评估该战略相对的有效性 历史入学率和保留率。我们将重新调整 JHLS-III 的用途并将其扩展为一个强大的纵向 由 8,000 名参与者组成的队列，收集并存储生物样本、社会生态和健康状况数据，以便 回答有关 NCD（即癌症和 CVD）风险和结果的问题。我们将建立安全的数据 整合和共享平台，将牙买加队列与 CAP3 研究和其他研究联系起来 加勒比海和美国的队列，并进行初步分析以进行数据验证和协调。