Dietary Predictors of Congestive Heart Failure

充血性心力衰竭的饮食预测因素

基本信息

批准号：
7408798
负责人：
Emily B Levitan
金额：
$ 5.23万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-28 至 2010-02-27
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7408798
关键词：
Adherence Affect Aging American Behavioral Blood Glucose Blood Pressure Cardiovascular Diseases Cardiovascular system Cause of Death Cessation of life Cohort Studies Congestive Congestive Heart Failure Consumption Data Diabetes Mellitus Diagnosis Diet Dietary Carbohydrates Dietary Fatty Acid Dietary Intervention Dietary intake Disease Elderly Event Facilities and Administrative Costs Fishes Food Food Patterns Frequencies Glycemic Index Heart failure Hospitalization Hypertension Incidence Individual Inpatients Intake Language Link Linoleic Acids Linolenic Acids Long-Term Effects Mammography Marines Measures Metabolic Myocardial Infarction Omega-3 Fatty Acids Pattern Plants Polyunsaturated Fatty Acids Population Prevalence Prevention Prevention strategy Proportional Hazards Models Prospective Studies Questionnaires Rate Risk Risk Factors Testing Woman aged cardiovascular risk factor cohort follow-up hypertension treatment men middle age mortality older men prevent prospective

项目摘要

DESCRIPTION (provided by applicant): Congestive heart failure (CHF) is the most common cause of hospitalization among Americans aged 65 and older. Incidence and prevalence of CHF are increasing because of aging of the population and increased survival following myocardial infarction. Diet patterns and food choices may influence risk of CHF through myocardial infarction, hypertension, and diabetes or through more subtle metabolic disturbances. Dietary interventions have the potential to augment currently available behavioral and pharmacologic CHF prevention strategies, but currently little is known about the relationship between diet and CHF. We have developed three hypotheses regarding diet patterns and CHF: 1) Adherence to the DASH diet will reduce incidence of CHF in women and men; 2) Consumption of fatty fish, total omega-3 polyunsaturated fatty acids, and marine and plant derived omega-3 polyunsaturated fatty acids will reduce incidence of CHF in women and men; higher omega-6 to omega-3 ratio will be associated with increased risk; and 3) Higher dietary glycemic index and dietary glycemic load will be associated with increased risk of CHF in women. To evaluate these hypotheses, we will conduct a prospective study in the context of two well-characterized cohorts: the Swedish Mammography Cohort of over 36,000 women and the Cohort of Swedish Men which includes over 45,000 men. In these cohorts, diet was measured using validated food-frequency questionnaires. Individuals were followed from January 1, 1998 to December 31, 2003 through the Swedish inpatient and cause-of-death registers for first hospitalization due to or death from CHF, a diagnosis that has been shown to have high validity. We will use proportional hazards models to calculate incidence rate ratios of CHF associated with the dietary patterns. Plain language summary: Congestive heart failure is a common and often deadly disease, particularly among older adults. Currently little is known about dietary causes of congestive heart failure. We will evaluate whether adherence to the DASH diet, fatty fish and polyunsaturated fatty acids, and dietary glycemic index and glycemic load affect risk of congestive heart failure in two large groups, 36,000 women in the Swedish Mammography Cohort and 45,000 men in the Cohort of Swedish Men.

描述（由申请人提供）：充血性心力衰竭 (CHF) 是 65 岁及以上美国人住院的最常见原因。由于人口老龄化和心肌梗塞后生存率的增加，CHF 的发病率和患病率不断增加。饮食模式和食物选择可能会通过心肌梗塞、高血压和糖尿病或更微妙的代谢紊乱来影响慢性心力衰竭的风险。饮食干预有可能增强目前可用的行为和药物性慢性心力衰竭预防策略，但目前人们对饮食与慢性心力衰竭之间的关系知之甚少。我们提出了关于饮食模式和 CHF 的三个假设： 1) 坚持 DASH 饮食将降低女性和男性的 CHF 发病率； 2) 食用富含脂肪的鱼类、总omega-3多不饱和脂肪酸以及海洋和植物来源的omega-3多不饱和脂肪酸将降低女性和男性CHF的发病率； omega-6 与 omega-3 的比例越高，风险越高； 3) 较高的膳食血糖指数和膳食血糖负荷与女性患 CHF 的风险增加有关。为了评估这些假设，我们将在两个特征明确的队列中进行前瞻性研究：由超过 36,000 名女性组成的瑞典乳房 X 线摄影队列和由超过 45,000 名男性组成的瑞典男性队列。在这些队列中，使用经过验证的食物频率问卷来测量饮食。从1998年1月1日到2003年12月31日，通过瑞典住院患者和死因登记册对个人因CHF首次住院或死亡的情况进行了跟踪，这一诊断已被证明具有很高的有效性。我们将使用比例风险模型来计算与饮食模式相关的 CHF 发病率比率。通俗易懂的语言总结：充血性心力衰竭是一种常见且往往致命的疾病，尤其是在老年人中。目前，人们对充血性心力衰竭的饮食原因知之甚少。我们将评估坚持 DASH 饮食、多脂鱼和多不饱和脂肪酸以及膳食血糖指数和血糖负荷是否会影响两大组（瑞典乳房 X 光检查队列中的 36,000 名女性和瑞典队列中的 45,000 名男性）发生充血性心力衰竭的风险。男人。