Network For Emotional Wellbeing And Brain Aging (NEW Brain Aging)

情绪健康和大脑老化网络（新大脑老化）

• 批准号: 10762789
• 负责人: YEATES CONWELL
• 金额: $ 7.03万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762789
• 关键词: Address; Adult; Advisory Committees; Aging; Alzheimer' s disease related dementia; Animal Model; Animals; Area; Biological Markers; Brain; Brain imaging; Cohort Studies; Collaborations; Consultations; Data; Dementia; Development; Educational workshop; Elderly; Emotional; Ensure; Evaluation; Faculty; Funding; Future; Gerontology; Grant; Growth; Health; Heterogeneity; Human; Interdisciplinary Study; International; Intervention; Learning; Literature; Measurement; Measures; Mediating; Mental Health; Mentorship; Methods; Modeling; Nature; Neurosciences; Outcome; Paper; Pathologic; Peer Review; Personal Satisfaction; Pilot Projects; Population; Prevention strategy; Process; Productivity; Protocols documentation; Publishing; Quality of life; Regulation; Reproducibility; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk; Role; Series; Societies; Stress; Testing; Time; Universities; Update; Well in self; aging brain; biomarker identification; brain based; brain health; brain research; cohort; density; early detection biomarkers; healthspan; hedonic; human model; interest; meetings; neuroimaging; neuropathology; novel; prevent; repository; resilience; therapeutic target; web site; webinar

Project summary: Early evidence indicates an association between emotional (eudaimonic and hedonic) well- being (EWB) and underlying brain processes, and that those processes change with both normal and pathological brain aging. However, the nature of these associations, the mechanisms by which EWB and its component domains change with brain aging, and how those changes may be associated with common neuropathologies like Alzheimer’s disease and related dementias (ADRD), are largely unexplored. The objective of the Network for Emotional Well-being and Brain Aging (NEW Brain Aging) is to address priority area #2 – mechanistic research on the role of emotional well-being in health – of RFA-AT-20-003, identifying and testing mechanisms by which brain aging influences EWB and how EWB may impact risk for and progression of ADRD. Synthesizing human and animal literature, our premise is that relationships between EWB and ADRD are bidirectional – normal and pathological changes in aging brain influence EWB and EWB contributes to brain health and illness, such as ADRD. Further, we hypothesize that the relationships between EWB and the brain in older adults reflect aging-associated heterogeneity of brain (i.e., resilience, typical aging, or neuropathological changes), and that they are mediated by processes of appraisal and adaptation. To do so we will form a national, transdisciplinary collaborative that includes investigators representing research expertise in human and animal neuroimaging, stress regulation, ADRD research, EWB, and computational/quantitative methods. With direction of an Executive Committee and guided by an External Advisory Committee, NEW Brain Aging will undertake these specific aims: (1) To build an inter-university and transdisciplinary collaborative of senior and junior investigators interested in brain, aging, and EWB research from both human and animal fields; (2) To form a series of time-limited workgroups with relevant experts in the field, each working over 1-2 years, to establish priorities for NEW Brain Aging activities in each of three general areas: (a) brain mechanism research of EWB; (b) research of EWB’s impact on ADRD; and (c) translational animal and cross-species brain research methods; (3) To coalesce and coordinate resources to ensure the rigor and reproducibility of the brain-related EWB research; (4) To provide three types of pilot funding through rigorous peer review: (a) pilot research grants for junior faculty related to brain mechanism studies related to the relationship between EWB and dementia using human or animal models; (b) proof-of-concept grants for established investigators to test aspects related to EWB in their existing studies and cohorts of brain aging; (c) seed collaboration grants for cross-species brain research related to EWB; (5) To evaluate the network by tracking its activities, resource usage, and productivity, and conducting collaborative network density analysis throughout the 4-year grant; and (6) to ensure the wide dissemination of NEW Brain Aging products. By accomplishing these aims, we will strengthen a research network focusing on the brain mechanistic understanding of EWB and relationship between EWB and ADRD.

项目摘要：早期证据表明情感（Eudaimonic和Hedonic）良好之间的关联 存在（EWB）和基本的大脑过程，并且这些过程随正常和 病理大脑衰老。但是，这些关联的性质，EWB及其它的机制 组件域随着脑衰老而变化，以及这些变化如何与常见相关联 阿尔茨海默氏病和相关痴呆症（ADRD）等神经病理学基本上是意外的。目标 情绪健康和大脑衰老网络（新的大脑衰老）是解决优先区域＃2 - 关于情绪健康在健康中的作用的机械研究 - 识别和测试的RFA-AT-20-003 大脑老化会影响EWB的机制以及EWB如何影响ADRD的风险和进展。 综合人类和动物文学，我们的前提是EWB与ADRD之间的关系是 双向 - 大脑衰老的正常和病理变化影响EWB和EWB有助于大脑 健康与疾病，例如ADRD。此外，我们假设EWB与大脑之间的关系 在老年人中 更改），并且它们是由评估和适应过程介导的。为此，我们将组成一个国家， 跨学科合作培训包括代表人类和动物研究专业知识的研究人员 神经影像学，压力调节，ADRD研究，EWB和计算/定量方法。有方向 在执行委员会的委员会和外部咨询委员会的指导下，新的大脑衰老将进行 这些具体目的：（1）建立高级和初级的大学间和跨学科合作 对人类和动物领域的大脑，衰老和EWB研究感兴趣的研究者； （2）形成一个 一系列限时的工作组与该领域的相关专家，每个工作组，每位工作组1 - 2年以上，以建立 在三个一般领域中每个领域的新大脑衰老活动的优先级：（a）EWB的大脑机理研究； （b）研究EWB对ADRD的影响； （c）翻译动物和跨物种脑研究方法； （3）结合和协调资源，以确保与大脑相关的EWB的严格和繁殖 研究; （4）通过严格的同伴评论提供三种类型的飞行员资金：（a）试点研究赠款 使用与EWB与痴呆症之间关系有关的大脑机制研究的初级教师 人类或动物模型； （b）概念验证赠款，已建立的研究人员测试与EWB相关的方面 在他们现有的研究和脑老化的同类中； （c）跨物种大脑研究的种子协作赠款 与EWB有关； （5）通过跟踪其活动，资源使用和生产力来评估网络，并 在整个4年赠款中进行协作网络密度分析； （6）确保宽阔 传播新的大脑老化产品。通过完成这些目标，我们将加强研究 网络着重于大脑对EWB的机理理解以及EWB与ADRD之间的关系。