Circulating Tumor Cells in Non-Small Cell Lung Cancer

非小细胞肺癌中的循环肿瘤细胞

基本信息

批准号：
7656775
负责人：
Jorge J. Nieva
金额：
$ 33.73万
依托单位：
BILLINGS CLINIC FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-24 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7656775
关键词：
Antineoplastic Agents Blood Cancer Center Cancer Patient Cell Count Cells Cellular Morphology Characteristics Clinical Data Detection Development Disease Event Experimental Designs Fiber Future Heterogeneity Image Incidence Institutes Investments Laboratories Malignant Epithelial Cell Malignant neoplasm of lung Measurement Measures Methods Morphology Non-Small-Cell Lung Carcinoma Outcome Patient Care Patients Peripheral Blood Mononuclear Cell Pharmacotherapy Phenotype Prevalence Prognostic Marker Proteins Provider Recording of previous events Research Personnel Resources Risk Scanning Science Specimen Speed Staining method Stains Surface Antigens Technology Testing Training Treatment Efficacy United States National Institutes of Health Validation Whole Blood cancer care cancer cell cancer type cell determination chemotherapy cohort design disorder control effective therapy improved insight lung Carcinoma malignant breast neoplasm neoplastic cell outcome forecast patient population peripheral blood prognostic programs tool

项目摘要

DESCRIPTION (provided by applicant): This proposal will seek to determine the characteristics and prognostic relevance of circulating tumor cell measurements in patients with metastatic non-small cell lung carcinoma. The use of circulating tumor cell determinations has already shown to be useful in the care of patients with metastatic breast cancer. The currently available technology is not suitable for use in non-small cell lung cancer due to the heterogeneity of cell markers that are required for circulating tumor cell measurement as presently performed. We will leverage the current investment by the National Institutes of Health for the development of the FAST cytometer as a tool for rare event imaging and apply it to lung cancer. This proposal will test the hypothesis that circulating tumor cell determinations can serve as a useful prognostic marker in non-small cell lung cancer by achieving the following specific aims: 1. To characterize circulating tumor cells in patients with non-small cell lung cancer 2. To prospectively determine the correlation between circulating tumor cell count and survival in metastatic non-small cell lung cancer 3. To correlate the effect of standard lung cancer drug therapy efficacy with circulating tumor cell count. We will use a training set of patients to determine the cell morphology and prevalence of circulating tumor cells in patients with metastatic disease. The morphologic and numeric determinants of circulating tumor cells on patient survival will then be validated in a separate patient cohort. Subsequently, patients will be followed over the history of their disease to establish the effect of drug therapy on these cells.

描述（由申请人提供）：该提案将旨在确定转移性非小细胞肺癌患者循环肿瘤细胞测量的特征和预后相关性。循环肿瘤细胞测定的使用已经证明在转移性乳腺癌患者的护理中有用。当前可用的技术不适合用于非小细胞肺癌，这是由于细胞标记的异质性，这些细胞标记是目前所需的循环肿瘤细胞测量所需的。我们将利用美国国立卫生研究院（National Institutes of Health）的当前投资来开发快速细胞仪，作为罕见事件成像的工具，并将其应用于肺癌。 This proposal will test the hypothesis that circulating tumor cell determinations can serve as a useful prognostic marker in non-small cell lung cancer by achieving the following specific aims: 1. To characterize circulating tumor cells in patients with non-small cell lung cancer 2. To prospectively determine the correlation between circulating tumor cell count and survival in metastatic non-small cell lung cancer 3. To correlate the effect of standard lung cancer drug循环肿瘤细胞计数的治疗功效。我们将使用一组训练患者来确定转移性疾病患者中循环肿瘤细胞的细胞形态和患病率。然后，将在单独的患者队列中验证循环肿瘤细胞的形态和数字决定因素。随后，将遵循患者的疾病病史，以确定药物治疗对这些细胞的影响。