Neurobehavioral Mechanisms of Emotion Regulation in Depression across the Adult Lifespan

成年期抑郁症情绪调节的神经行为机制

• 批准号: 9883047
• 负责人: KEVIN S LABAR
• 金额: $ 63.29万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9883047
• 关键词: Adult; Adverse event; Affect; Affective; Age; Aging; Amygdaloid structure; Attention; Behavioral; Brain; Brain region; Clinical; Cognitive; Conscious; Depressed mood; Diagnosis; Diagnostic; Dorsal; Down-Regulation; Effectiveness; Elderly; Emotional; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Growth; Health; Health system; Individual; Individual Differences; Intervention; Link; Longevity; Major Depressive Disorder; Mental Depression; Mental Health; Modeling; Morbidity - disease rate; Neurocognition; Neurocognitive; Neurocognitive Deficit; Parietal; Participant; Pathway interactions; Patients; Performance; Population; Prediction of Response to Therapy; Predisposition; Process; Public Health; Quality of life; Regulation; Research; Research Design; Resources; Risk; Sampling; Scanning; Severities; Social support; Structure; Symptoms; Testing; age group; age related; age related cognitive change; attentional bias; base; behavior test; brain circuitry; cognitive control; cognitive function; cognitive process; cognitive reappraisal; cost; depressive symptoms; disability; distraction; effective intervention; emotion dysregulation; emotion regulation; executive function; follow-up; healthy aging; improved; indexing; innovation; insight; mood symptom; negative affect; negative mood; neural circuit; neurobehavioral; neuroimaging; novel; preservation; relating to nervous system; response; sex; stressor; success; young adult

ABSTRACT The ability to regulate one’s emotional responses is critical for maintaining emotional health in the face of adverse events that cumulate over the lifespan. Although some emotion regulation abilities are thought to be maintained or even improve in healthy older adults, such beneficial maturation effects are moderated by individual differences in depression and neurocognition that contribute to disability, morbidity, and loss of quality of life into old age. Frontolimbic circuit dysfunction is a hallmark of both younger and older adults with major depressive disorder (MDD), while both activation in and connectivity among components of these circuits predicts treatment response. Such disruptions impact core cognitive processes, including cognitive control and attentional biasing, that influence emotion regulation ability, although it is unknown how their susceptibility to depressive influences varies across the adult lifespan. Moreover, MDD patients are less able to utilize compensatory resources that help older adults cope with adversity, such as social support, in the face of age- associated neurocognitive decline. Given the projected growth of the elderly population in the U.S. and the associated burden on the public health system, it is imperative to develop effective interventions to target regulatory deficits associated with depression in late life and to begin to identify neurocognitive predictors of increasing depressive symptoms. Preliminary evidence from the study team demonstrates that the effectiveness of regulatory strategies such as reappraisal and distraction vary with age and depressive status. However, there is a pressing need for a comprehensive, integrative approach to study emotion regulation strategy use that links brain circuitry integrity, cognitive function, social support, and clinical symptoms, and investigates how these relationships change with age. The central hypothesis of the proposed study is that age, diagnostic status, neurocognitive functioning, and social support will differentially impact reappraisal and distraction efficacy, and that their combined effect on strategy use will predict depressive symptoms at 1 year post-scan. The proposed study is expected to yield new insights in how maturational changes contribute to the conscious ability to reduce negative affect in depressed adults. A total of 200 adults in stratified age groups from 35 to 75 years with and without MDD will undergo structural and task-based functional neuroimaging. We will test age- and diagnosis-specific differences in the success of two different emotion regulation strategies in reducing experimentally induced negative affect, identify brain regions associated with successful use of reappraisal and distraction using structural and functional magnetic resonance imaging, and test emotion regulation as a predictor of future depression symptom severity. Results will be used to better target emotion regulation interventions based on a patient’s age and diagnostic status.

抽象的 调节情绪反应的能力对于在面对困难时保持情绪健康至关重要 尽管一些情绪调节能力被认为是在一生中累积的不良事件。 在健康的老年人中维持甚至改善，这种有益的成熟效应受到以下因素的调节 抑郁症和神经认知方面的个体差异导致残疾、发病和丧失能力 额叶回路功能障碍是年轻人和老年人的一个标志。 重度抑郁症（MDD），而这些回路的激活和组件之间的连接 预测治疗反应，这种干扰会影响核心认知过程，包括认知控制和 注意力偏差会影响情绪调节能力，尽管尚不清楚他们的易感性如何 此外，MDD 患者的利用能力较差。 帮助老年人应对逆境的补偿性资源，例如面对年龄增长的社会支持 鉴于美国老年人口的预计增长和相关的神经认知能力下降。 公共卫生系统的相关负担，因此必须制定有效的干预措施来瞄准 与晚年抑郁症相关的调节缺陷，并开始识别抑郁症的神经认知预测因子 研究小组的初步证据表明，抑郁症状增加。 重新评估和分散注意力等监管策略的有效性随年龄和抑郁状态而变化。 然而，迫切需要一种全面、综合的方法来研究情绪调节 将大脑回路完整性、认知功能、社会支持和临床症状联系起来的策略使用，以及 调查这些关系如何随年龄变化。本研究的中心假设是： 年龄、诊断状态、神经认知功能和社会支持将对重新评估和社会支持产生不同的影响 分散注意力的功效，结合它们对策略使用的影响将预测一年后的抑郁症状 扫描后，拟议的研究预计将产生关于成熟变化如何促进的新见解。 减少抑郁成年人负面影响的意识能力 共有 200 名分层年龄组的成年人。 从 35 岁到 75 岁，患有或不患有 MDD 的人都将接受结构和基于任务的功能神经影像检查。 将测试两种不同情绪调节策略成功与否的年龄和诊断特异性差异 减少实验引起的负面影响的区域，识别与成功使用相关的大脑 使用结构和功能磁共振成像重新评估和分散注意力，并测试情绪 调节作为未来抑郁症状严重程度的预测因子，结果将用于更好地瞄准情绪。 根据患者的年龄和诊断状态进行监管干预。