Patient-Oriented Research in Global Cardiovascular Diseases and Interactions with HIV

全球心血管疾病及其与艾滋病毒相互作用的以患者为导向的研究

基本信息

批准号：
10762609
负责人：
Robert N Peck
金额：
$ 12.63万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10762609
关键词：
AIDS prevention Address Adolescent Adult Africa African Ambulatory Care Facilities Award Biological Markers Blood Pressure Cardiovascular Diseases Caring Chronic Disease Clinic Clinical Clinical Investigator Clinical Trials Cluster randomized trial Communities Community Health Aides Development Diagnosis Diastolic heart failure Disease Echocardiography Environment Event Eye Faculty Family Fellowship Foundations Functional disorder Funding Galectin 3 Goals Grant Guidelines HIV Heart Hospital Mortality Hospitalization Hospitals Hybrids Hypertension Institution Interdisciplinary Study International Intervention Kenya Kidney Leadership Learning Life Style Link Low income Medicine Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Modeling Morbidity - disease rate Myocardial dysfunction Nursing Faculty Organ Patients Persons Pharmaceutical Preparations Physicians Plasma Population Prevention therapy Privatization Productivity Proteins Proteomics Reference Standards Religion Research Research Personnel Research Project Grants Research Training Risk Factors Role Rural Sampling Schools Scientist Site Sleep Social Workers Tanzania Testing Time Training Troponin I Trust United States United States National Institutes of Health biobank biomarker identification blood pressure elevation blood pressure reduction cardiovascular disorder epidemiology cardiovascular disorder prevention cardiovascular disorder risk clinical implementation cohort community center community engagement cost cost effective design empowerment evidence base experience follow-up health disparity hypertension treatment hypertensive implementation science implementation trial implementation/effectiveness improved innovation medical schools member mortality novel novel marker patient oriented patient oriented research point of care point of care testing poor communities poor sleep predictive marker prevent pro-brain natriuretic peptide (1-76)research study risk stratification skills training opportunity young adult

项目摘要

ABSTRACT: The goals of this K24 application are for Dr. Robert Peck to train physician-scientists in the conduct of patient-oriented cardiovascular disease (CVD) research in East Africa, and to conduct a new study of novel biomarkers predicting the onset of diastolic dysfunction of the heart (Aim 1). The candidate has lived and conducted research in Tanzania for the past 15 years. He helped to establish a new medical college and developed longstanding partnerships with leading research organizations in Tanzania (MITU) and Kenya (KWTRP). These partnerships, with the ongoing research studies, provide him with an outstanding research environment to study CVD in the context of Africa while also training a cadre of young investigators. The training that he offers leverage 3 NIH R01 funded projects in Tanzania (Aims 2-4), foundation awards (Aim 5), and a newly funded CVD research project in Kenya (Aim 6). United States (US) trainees from Weill Cornell Medicine will be supported by NIH T32 training grants and spend ~50% of their time at research sites in East Africa, which have longstanding international collaborators and excellent research training environments. East African trainees will be supported by two NIH D43 training grants and institutional funds. The common theme is that all of the research projects have patient-oriented research on CVD as the focus, with an emphasis on interactions with HIV, and will serve as vehicles for mentored research training. The specific aims include: 1. Biomarkers for incident diastolic dysfunction in people living with HIV (PLWH) in Tanzania 2. HIV, sleep, nocturnal blood pressure, and CVD in Tanzania 3. A cluster randomized trial of engaging religious leaders to reduce blood pressure in Tanzania 4. Reducing post-hospital mortality related to severe hypertension in Tanzania 5. Causes and consequences of hypertension in adolescents in Tanzania 6. Point-of-care risk stratification for community-centered hypertension treatment in Kenya The focus of research training will be on a diverse pool of clinical trainees, ranging from residents to fellows to clinical faculty. The candidate has a strong track record of mentoring patient-oriented researchers in Tanzania and participates in multiple private and NIH sponsored research fellowships at Weill Cornell. Trainees will participate in research projects in Tanzania (Aims 1-5) and also in Kenya (Aim 6). Trainees learn through the conduct of their mentored research project and partnerships with colleagues from the US and East Africa on related studies. The K24 award will enable the candidate to decrease his administrative responsibilities and commit at least 25% effort to CVD research mentorship of US and Tanzanian trainees. As part of the K24, he will pursue formal training in mentorship as well as strengthening his skills in translational biomarker research.

摘要：此K24应用程序的目标是Robert Peck博士在培训医师科学家中的目标东非进行以患者为导向的心血管疾病（CVD）研究，并进行一项新研究新型生物标志物预测心脏舒张功能障碍的发作（AIM 1）。候选人生活了在过去的15年中，在坦桑尼亚进行了研究。他帮助建立了新的医学院，与坦桑尼亚（MITU）和肯尼亚领先的研究组织建立了长期的合作伙伴关系（kwtrp）。这些与正在进行的研究的伙伴关系为他提供了出色的研究在非洲背景下研究CVD的环境，同时还培训了一群年轻的研究人员。这培训他为坦桑尼亚（AIMS 2-4），Foundation Awards（AIM 5）提供杠杆杠杆3 R01资助的项目（AIM 5），以及肯尼亚新资助的CVD研究项目（AIM 6）。来自威尔·康奈尔（Weill Cornell）的美国（美国）学员 NIH T32培训补助金将支持医学非洲，拥有长期的国际合作者和出色的研究培训环境。东方非洲学员将获得两名NIH D43培训补助金和机构资金的支持。共同的主题是所有研究项目都以患者为导向的CVD作为重点，重点是与艾滋病毒的互动，并将作为指导研究培训的工具。具体目的包括： 1。坦桑尼亚患艾滋病毒（PLWH）患者的舒张期功能障碍的生物标志物 2。艾滋病毒，睡眠，夜间血压和坦桑尼亚的CVD 3。一项与宗教领袖降低坦桑尼亚血压的群集随机试验 4。降低与坦桑尼亚严重高血压有关的院后死亡率 5。坦桑尼亚青少年高血压的原因和后果 6。肯尼亚以社区为中心的高血压治疗的护理点风险分层研究培训的重点将放在各种各样的临床学员身上，从居民到研究员到临床教师。该候选人在坦桑尼亚指导面向患者的研究人员的良好记录并参加了Weill Cornell的多个私人和NIH赞助的研究奖学金。学员会参加坦桑尼亚的研究项目（AIMS 1-5）和肯尼亚（AIM 6）。学员通过他们的指导研究项目以及与美国和东非同事的合作伙伴关系相关研究。 K24奖将使候选人能够降低其行政责任和至少努力为美国和坦桑尼亚学员的CVD研究指导。作为K24的一部分，他将在指导方面进行正式培训，并增强他在转化生物标志物研究方面的技能。