GENOMICE (Game Exploring Nuances in Offspring to Master Interactions of Chromosome Expression)

GENOMICE（探索后代细微差别以掌握染色体表达相互作用的游戏）

• 批准号: 10760456
• 负责人: Eric Aaron
• 金额: $ 39.99万
• 依托单位: SMART INFORMATION FLOW TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10760456
• 关键词: Achievement; Address; Albinism; Alleles; Artificial Intelligence; Awareness; Behavior; Breeding; Businesses; COVID-19 pandemic; Career Choice; Chromosomes; Cognitive; Color; Computer Models; Computers; Consult; Decision Making; Dimensions; Disease model; Education; Educational Models; Educational process of instructing; Elements; Ensure; Environment; Environment Design; Expert Systems; Exposure to; Feedback; Funding; Future; Genomics; Genotype; Goals; Health; Healthcare; High School Student; Individual; Industry; Institution; Intervention; Interview; Judgment; Laboratories; Learning; Measures; Mechanics; Minor; Modeling; Modernization; Monitor; Motivation; Mus; Mutation; National Human Genome Research Institute; Occupations; Online Systems; Parents; Performance; Persons; Phase; Phenotype; Pilot Projects; Play; Population; Preventive care; Preventive treatment; Problem Solving; Quantitative Reasoning; Recording of previous events; Regulation; Research; Role; Science; Specimen; Strategic vision; Structure; Students; Technology; Technology Transfer; Testing; Training; Underrepresented Students; United States; Universities; Work; albino mouse; analytical tool; career; college; cost; design; digital; empowerment; experience; health application; high school; improved; instructor; interest; laboratory experience; learning outcome; literacy; medical complication; offspring; pedagogy; personalized learning; pilot test; programs; prototype; recruit; skills; student participation; student training; success; tool; trait; undergraduate student; university student; usability

PROJECT SUMMARY Genomics has become an essential element of biomedical science, playing multiple roles in rapidly addressing the COVID-19 pandemic, understanding medical complications to develop more effective preventative care and treatments, and modeling diseases in laboratory specimens for study. Despite the increasing relevance of genomics to people's everyday lives, genomics literacy in the United States remains low. In addition, the genomics workforce in the United States is still far from achieving the NHGRl's Strategic Vision with respect to diversity. To address these societal needs, it is critical to expose people to genomics careers and educate them on related topics while they contemplate future career pathways. To maximize the impact of such an effort, students at the high school and undergraduate level need access to a higher-quality genomics education to seed their interest in pursuing genomics careers and improve the diversity of the genomics workforce. To meet this critical need, SIFT, Colby College, and Jackson Labs propose GENOMICE (Game Exploring Nuances in Offspring to Master Interactions of Chromosome Expression), a low-cost, web-based digital game that teaches college and high school students to think about genomics quantitatively, probabilistically, and predictively through active engagement, strategic problem-solving, and customized feedback emulating how genomics instructors teach their students. Non-violent gameplay and characters representative of many dimensions of diversity will present an inclusive environment designed to appeal to students regardless of their experiences playing games. Phase I of this Small Business Technology Transfer (STTR) project will produce a low-fidelity prototype with tasks demonstrating specific game mechanics designed to teach core genomics concepts: identifying phenotypes, predicting genotypes, and developing breeding strategies to selectively produce offspring populations and traits (Aim 1 ). GENOMICE will also include a cutting-edge artificial intelligence (Al) system that monitors player performance and appropriately modifies game content to improve learning outcomes (Aim 2). GENOMICE's low-fidelity prototype will be evaluated in terms of usability and enjoyability in a pilot study with college students in introductory genomics courses (AIM 3). GENOMICE will be the first scalable, game-based, and adaptive genomics education tool targeting core genomics concepts and promoting transfer of in-game learning to traditional genomics assessments. GENOMICE will be a webbased game, allowing easy set up and scalability regardless of individual computers' capabilities. Making GENOMICE commercially available to universities, genomics research institutions, high schools, and the genomics industry has the potential to increase student engagement with genomics and give students of all backgrounds the skills needed for future genomics careers.

项目摘要 基因组学已成为生物医学科学的基本要素，在快速解决的问题方面发挥了多种作用 COVID-19大流行，了解医学并发症以开发更有效的预防性护理和治疗， 并在实验室标本中建模疾病以进行研究。尽管基因组学与人们的相关性越来越大 日常生活，美国的基因组学素养仍然很低。此外，曼联的基因组劳动力 国家还没有实现NHGRL在多样性方面的战略愿景。为了满足这些社会需求， 至关重要 职业道路。为了最大程度地发挥这种努力的影响，高中和本科级别的学生需要 获得高质量的基因组学教育，以播种他们对从事基因组学职业的兴趣并改善 基因组劳动力的多样性。 为了满足这一关键需求，SIFT，Colby College和Jackson Labs提出了Genomice（游戏探索细微差别 在掌握染色体表达的互动的后代），这是一种基于网络的低成本数字游戏，教学学院 高中生可以通过活跃地进行定量，概率和预测性地思考基因组学 参与，战略性问题解决以及定制反馈模仿基因组教师如何教学生。 非暴力游戏玩法和代表多样性维度的角色将带来包容性 旨在吸引学生的环境，无论他们玩游戏的经验如何。 这个小型企业技术转移（STTR）项目的第一阶段将产生一个低保真原型的任务 展示旨在教授核心基因组学概念的特定游戏机制：识别表型，预测 基因型，并制定育种策略，以选择性地产生后代人群和特征（AIM 1）。 Genomice还将包括一个尖端的人工智能（AL）系统，该系统可监视玩家性能和 适当修改游戏内容以改善学习成果（AIM 2）。 Genomice的低保真原型将是 在一项试点研究中，与大学生一起在入门基因组学课程中对可用性和享受性进行了评估 （目标3）。 基因组将是针对核心基因组学的第一个可扩展，基于游戏和自适应基因组学教育工具 概念和促进游戏中学习转移到传统基因组学评估。 Genomice将是一个基于网络的 游戏，无论单个计算机的功能如何，都可以轻松设置和可扩展性。制作基因组 大学，基因组学研究机构，高中和基因组学行业的市售 增加学生参与基因组学的潜力，并为所有背景的学生提供所需的技能 未来的基因组学职业。