AIDS Clinical Trials Group Network

艾滋病临床试验小组网络

基本信息

批准号：
7492221
负责人：
CONSTANCE ANN BENSON
金额：
$ 3689.01万
依托单位：
SOCIAL AND SCIENTIFIC SYSTEMS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-29 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7492221
关键词：
AIDS clinical trial group AIDS-Related Opportunistic Infections Acquired Immunodeficiency Syndrome Address Adherence Adolescent Africa Alabama Alleles Amendment Antigen-Presenting Cells Antiviral Agents Area Arts Asia Award Back Biological Biological Assay Biological Products Biomedical Research Blood Blood specimen Boston Buffaloes CD8B1 gene California Caribbean natives Caribbean region Caring Cell physiology Cells Cerebrospinal Fluid Cervical Characteristics Childhood Clinical Clinical Management Clinical Pharmacology Clinical Research Clinical Trials Clinical Trials Network Clinical trial protocol document Collaborations Colorado Committee Members Competence Complementary DNA Complex Condition Consensus Contracts Coombs&apos Test Country Critiques Cytomegalovirus DNA Data Data Analyses Dendritic Cells Dental Depth Detection Development Discipline Disease Progression Doctor of Medicine Doctor of Philosophy Dose Drug Evaluation Drug Exposure Drug Interactions Drug Kinetics Drug Monitoring Drug resistance End Point Ensure Epidemic Equipment Equipment and supply inventories Escape Mutant Evaluation Exhibits Freezing Frequencies Funding Gender Gene Targeting General Hospitals Genes Genital system Genomics Genotype Goals Growth HIV HIV Infections HIV prevention trials network HIV vaccine HIV-1 HIV-1 drug resistance HIV-1 protease HIV-1 vaccine Head Health Sciences Health Services Research Hepatitis B Hepatitis B Virus Hepatitis C Hepatitis C virus Hepatitis Viruses Human Human Herpesvirus 8 Human Resources Immune Immune response Immunity Immunization Immunologic Markers Immunologic Monitoring Immunologics Immunologist Immunology Immunotherapeutic agent Immunotherapy In Vitro Individual Industry Infection Inflammatory Informatics Institutes International International Maternal Pediatric Adolescent AIDS Clinical Trials Group Intervention Investigation Israel Knowledge Laboratories Laboratory Research Latin America Leadership Length Ligation Link Liver Liver diseases Lymphoid Malaria Massachusetts Measurement Measures Medical center Methods Microbicide Trials Network Minor Minority Mission Modeling Molecular Cloning Monitor Morbidity - disease rate Multi-Drug Resistance Mutation Mycobacterium Infections NNRTI-resistance Natural Immunity Neuraxis New York Oligonucleotides Operative Surgical Procedures Oral health Other Therapy Outcome Pathogenesis Pathway interactions Patients Peer Review Performance Peripheral Blood Mononuclear Cell Persons Pharmaceutical Preparations Pharmacogenomics Pharmacology Pharmacology, Other Phase Phenotype Phylogenetic Analysis Plasma Play Polymerase Polymerase Chain Reaction Population Predisposition Pregnant Women Prevention Principal Investigator Procedures Process Productivity Protease Inhibitor Protein Binding Protocols documentation Publications Publishing Purpose Qualifying Quality Control RNA RNA-Directed DNA Polymerase Range Recombinants Recovery Reference Standards Relative (related person)Reporting Research Research Activity Research Design Research Infrastructure Research Institute Research Personnel Research Priority Resistance Resource Sharing Resources Reverse Transcriptase Polymerase Chain Reaction Role Safety Sampling San Francisco Science Scientist Selection Criteria Seminal fluid Services Sex Characteristics Silver Site Site-Directed Mutagenesis Specimen Standards of Weights and Measures Statistical Data Interpretation Structure Surveys System Talents Technical Expertise Techniques Technology Technology Transfer Testing Therapeutic Therapeutic Agents Therapeutic Clinical Trial Therapy Clinical Trials Time Tissues Total Quality Management Training Programs Translating Translational Research Translations Treatment Failure Treatment Protocols Treatment outcome Tuberculosis United States United States National Institutes of Health Universities Vaccination Vaccine Research Vaccines Validation Variant Vertical Disease Transmission Victoria Austrailia Viral Viral Pathogenesis Viral hepatitis Viremia Virus Virus Replication Washington Woman Work abstracting analytical method antiretroviral therapy assay development base bench to bedside clinical research site clinically relevant concept cost craniofacial data management data modeling design drug development experience fitness genome sequencing immune function improved in vivo innovation interest intrahepatic killer T cell lymph nodes medical schools medical specialties member models and simulation mortality novel novel therapeutics online tutorial oral HIV organizational structure pathogen peer pharmacokinetic model prevent programs quality assurance reconstitution repository research and development resistance mechanism response restoration skills social statistics success therapeutic vaccine treatment trial tripolyphosphate vaccination strategy virology volunteer

项目摘要

DESCRIPTION (provided by applicant): The mission of the AIDS Clinical Trials Group (ACTG) is to develop and conduct scientifically rigorous translational research and therapeutic clinical trials to: 1) investigate the viral and immune pathogenesis of HIV-1 infection and its complications; 2) evaluate novel therapeutic agents and the most effective approaches and strategies for the use of existing agents to treat HIV-1 infection; 3) evaluate interventions and strategies to treat and prevent HIV-related opportunistic infections, co-infections, complications of therapies, and other HIV-1-related co-morbidities, and 4) publish and disseminate the findings from these studies for the purpose of improving clinical care, preventing or delaying HIV disease progression, and reducing or eliminating the morbidity and mortality associated with HIV-1 infection and its associated complications. In this application the ACTG proposes a comprehensive, integrated clinical and translational research program that addresses five of the six scientific areas outlined under this RFA: 1) Translational Research and Drug Development; 2) Optimization of Clinical Management, including Co-Infection; 3) Vaccine Research and Development; 4) Prevention of Mother to Child Transmission, and 5) Prevention of HIV Infection. An Oral Health program will be undertaken in collaboration with investigators supported by the National Institute of Dental and Craniofacial Research. This program will be conducted in collaboration with the HIV Prevention Trials Network (HPTN), the HIV Vaccine Trials Network (HPTN), the IMPAACT network and the Microbicide Trials Network (MTN). The proposed research agenda as well as the Group Leadership and organizational structure reflect the worldwide impact of the HIV epidemic. We propose to conduct the work using a network of 72 clinical research sites in the United States and 12 countries in Africa, Asia, Latin America and the Caribbean. The network is actively supported by an integrated network of Core Laboratories with broad expertise in virology, pharmacology, immunology, and genomics. The ACTG Operations Center, located in Silver Spring, MD, provides key operational, administrative, and fiscal support. Statistical expertise and data management resources are provided by the Statistics and Data Management Center in Boston, MA and Buffalo, NY. CORE (P.I. Benson, Constance) CORE: Translational Research/Drug Development

描述（由申请人提供）：艾滋病临床试验小组 (ACTG) 的使命是开发和开展科学严谨的转化研究和治疗性临床试验，以： 1) 研究 HIV-1 感染及其并发症的病毒和免疫发病机制； 2）评估新型治疗药物以及使用现有药物治疗HIV-1感染的最有效方法和策略； 3) 评估治疗和预防 HIV 相关机会性感染、合并感染、治疗并发症和其他 HIV-1 相关合并症的干预措施和策略，以及 4) 发表和传播这些研究的结果，目的是：改善临床护理，预防或延缓 HIV 疾病进展，并减少或消除与 HIV-1 感染及其相关并发症相关的发病率和死亡率。在此申请中，ACTG 提出了一项全面、综合的临床和转化研究计划，涉及本 RFA 概述的六个科学领域中的五个：1) 转化研究和药物开发； 2）优化临床管理，包括合并感染； 3）疫苗研发； 4) 预防母婴传播，以及 5) 预防艾滋病毒感染。将与国家牙科和颅面研究所支持的研究人员合作开展口腔健康计划。该计划将与艾滋病毒预防试验网络 (HPTN)、艾滋病毒疫苗试验网络 (HPTN)、IMPAACT 网络和杀菌剂试验网络 (MTN) 合作进行。拟议的研究议程以及小组领导和组织结构反映了艾滋病毒流行的全球影响。我们建议利用美国 72 个临床研究中心以及非洲、亚洲、拉丁美洲和加勒比地区 12 个国家的网络来开展这项工作。该网络得到了核心实验室综合网络的积极支持，这些实验室在病毒学、药理学、免疫学和基因组学方面拥有广泛的专业知识。 ACTG 运营中心位于马里兰州银泉，提供关键的运营、行政和财政支持。统计专业知识和数据管理资源由位于马萨诸塞州波士顿和纽约州布法罗的统计和数据管理中心提供。核心（P.I.本森，康斯坦斯）核心：转化研究/药物开发