International Research Collaboration on Neuroimaging Studies of Alcoholism

酒精中毒神经影像学国际研究合作

• 批准号: 9042901
• 负责人: Adolf Pfefferbaum
• 金额: $ 24.78万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9042901
• 关键词: Accounting; Alcohol Amnestic Disorder; Alcohol consumption; Alcoholism; Alcohols; Award; Basic Science; Behavioral; Biological; Biological Markers; Blood; Brain; Chronic; Cognitive; Collaborations; Country; DSM-V; Data; Data Analyses; Data Collection; Diagnostic; Doctor of Medicine; Doctor of Philosophy; Episodic memory; Ethnic Origin; Fiber; Folic Acid; France; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Genes; Genetic Markers; Genotype; Health; Hematocrit procedure; Hemoglobin; Heterogeneity; Hippocampus (Brain); Homocysteine; Homocystine; Hospitals; Human; International; Korea; Koreans; Laboratories; Magnetic Resonance Imaging; Measures; Memory; Motor; NIH Program Announcements; National Institute on Alcohol Abuse and Alcoholism; Nervous system structure; Neuraxis; Neuropsychology; Neurosciences; Nutritional; Nutritional status; Outcomes Research; Patients; Pattern; Principal Investigator; Procedures; Protocols documentation; Recording of previous events; Recovery; Red Blood Cell Count; Research; Research Personnel; Rest; Risk Factors; Scientist; Secure; Single Nucleotide Polymorphism; Site; South Korea; Structure; System; Testing; Thalamic structure; Therapeutic; Thiamine; Thiamine Pyrophosphate; Translational Research; U-Series Cooperative Agreements; United States; Universities; Variant; Visit; Wernicke-Korsakoff Syndrome; Whole Blood; Work; Writing; addiction; alcohol effect; brain volume; cerebrovascular; genetic variant; indexing; interest; mean corpuscular volume observed; neuroimaging; neuropsychological; nutrition; problem drinker; programs; relating to nervous system; response

DESCRIPTION (provided by applicant): This application for a competing renewal of a U01 cooperative agreement award is written in response to Program Announcement (PA) number PAR-11-282, "International Research Collaboration on Alcohol and Alcoholism." Receipt of this award would enable us to continue a program of international collaborations among the well-established nationally funded research groups at INSERM/University of Caen site in France directed by Francis Eustache, Ph.D., the recently-established addictions research program at the Yonsei University affiliated Severance Hospital in Seoul, South Korea directed by Young-Chul Jung, M.D., Ph.D., and our longstanding neuroimaging and neuroscience laboratories funded principally by NIAAA, in the United States at Stanford University with Edith Sullivan, Ph.D., Principal Investigator (MPI) and at SRI International with Adolf Pfefferbaum, M.D. (MPI). The overarching aim of this collaboration is 1) to use neuroimaging, neuropsychology, and biomarkers of nutrition in alcoholics, with and without KS, and controls to compare and contrast the effects of alcohol on brain structure and function across nations and 2) to identify markers of nutritional status, genetic variants, and alcohol consumption patterns that modulate the principal dependent measures and explain heterogeneity in presentation and recovery of alcoholism. Three specific aims with testable hypotheses are proposed: 1. Prospectively screen with common diagnostic DSM-V criteria 100 alcoholics, 100 controls, and 10 KS in each country-U.S., France, and South Korea-and acquire the following data: 1a. Neuroimaging (MRI, FLAIR, DTI, and rs-fMRI) data using common protocols developed over the current funding period. 1b. Neuropsychological data using the common long and newly developed short test batteries. 1c. Blood for analysis of biomarkers of nutritional status (hemogram for red blood cell count, hematocrit, hemoglobin, mean corpuscular volume; vitamin B1 (whole blood thiamine diphosphate), folate, B12 and cerebrovascular risk factor (homocysteine). 1.d. Blood for analysis of thiamine transporter genotyping 2. Implement a secure pipeline for data reception, storage, analysis, and dissemination to and from project sites. 3. Conduct data analysis and hypothesis testing in collaboration with the project scientists (French and Korean visiting the U.S. and U.S. visiting France and Korea) and export results and analysis procedures to France and Korea.

描述（由申请人提供）：本 U01 合作协议奖励竞争续签申请是根据计划公告 (PA) 编号 PAR-11-282“酒精和酒精中毒国际研究合作”而编写的。获得该奖项将使我们能够继续在法国国家健康与医学研究所/卡昂大学的知名国家资助研究小组之间开展由弗朗西斯·尤斯塔什博士指导的国际合作计划，这是最近在法国卡昂大学建立的成瘾研究项目位于韩国首尔的延世大学附属 Severance 医院，由 Young-Chul Jung 医学博士、哲学博士领导，我们长期存在的神经影像和神经科学实验室主要由以下机构资助NIAAA 在美国斯坦福大学与首席研究员 Edith Sullivan 博士 (MPI) 合作，在 SRI International 与 Adolf Pfefferbaum 医学博士 (MPI) 合作。此次合作的总体目标是 1) 在酗酒者（无论是否患有 KS）和对照组中使用神经影像学、神经心理学和营养生物标志物来比较和对比酒精对各国大脑结构和功能的影响，以及 2) 识别标志物的 营养状况、遗传变异和饮酒模式调节主要依赖指标并解释酗酒表现和恢复的异质性。提出了三个具有可检验假设的具体目标： 1. 使用通用诊断 DSM-V 标准对每个国家（美国、法国和韩国）的 100 名酗酒者、100 名对照者和 10 名 KS 进行前瞻性筛查，并获取以下数据： 1a。使用当前资助期间开发的通用协议的神经影像（MRI、FLAIR、DTI 和 rs-fMRI）数据。 1b.神经心理学数据使用常见的长电池和新开发的短电池进行测试。 1c.用于分析营养状况生物标志物的血液（红细胞计数血象、血细胞比容、血红蛋白、平均红细胞体积；维生素 B1（全血二磷酸硫胺素）、叶酸、B12 和脑血管危险因子（同型半胱氨酸）。 1.d. 血液用于分析硫胺素转运蛋白基因分型分析 2. 实施安全管道，用于项目现场的数据接收、存储、分析和传播 3. 进行。与项目科学家（法国和韩国访问美国以及美国访问法国和韩国）合作进行数据分析和假设检验，并将结果和分析程序出口到法国和韩国。