WG3: HIV, Co-infections and Co-morbidities

WG3：艾滋病毒、合并感染和合并症

• 批准号: 9464628
• 负责人: ROBERT A SALATA
• 金额: $ 0.79万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9464628
• 关键词: AIDS/HIV problem; APOL1 gene; Acquired Immunodeficiency Syndrome; Address; African American; Area; Atherosclerosis; Biological Markers; Biology; Chronic; Clinical; Clinical Research; Collaborations; Comorbidity; Comprehensive Cancer Center; Development; Discipline; Disease; Evaluation; Fertilization; Fostering; Funding; Goals; Grant; HIV; HIV Infections; HIV/TB; Head and Neck Cancer; Heart Diseases; Human; Human Papillomavirus; Immune; Incidence; Inflammation; Institutes; Joints; Journals; Kidney; Laboratories; Link; Malignant Neoplasms; Measurement; Mentors; Microglia; Morbidity - disease rate; Neurocognitive; Neurons; Oncogenic; Pathogenesis; Patients; Peer Review; Prevalence; Process; Public Health; Publications; Publishing; Research; Research Personnel; Research Proposals; Resources; Role; Scientist; Uganda; Viral reservoir; Virus Replication; Vitamin D; Work; antiretroviral therapy; beta-Defensins; cancer education; cancer genetics; cardiogenesis; career; co-infection; design; genetic association; improved; interest; meetings; member; mortality; outcome forecast; pandemic disease; programs; reactivation from latency; risk variant; screening; success; translational scientist; virology; working group

Although antiretroviral therapy (ART) has dramatically altered the prognosis of HIV infection and improved the survival of patients, infected patients continue to suffer significant morbidity and mortality from TB, CVD, malignancies, chronic kidney, and neurocognitive disease. These issues highlight the fact that while ART is very effective at restricting viral replication, there is a pressing need to address the determinants of comorbidities, which are the critical issues in HIV research and the focus of the Working Group 3 agenda. The group has a remit to define scientific priorities in this area for the CFAR and then to facilitate advances in the field by promoting synergistic interactions and collaborative research proposals and advancing the careers of junior investigators. Working Group has 23 members, comprising a critical mass of clinical and translational researchers who have collectively published 423 peer-reviewed publications during the last funding cycle. The primary goal of WG3 is to promote interactions and collaborations between researchers at CWRU and beyond to unravel the biology co-morbid conditions in HIV infections. WG3 promotes this scientific agenda through a variety of activities including (1) facilitating collaborative research by sponsoring seminars, journal clubs, research-in-progress meetings, and targeted meetings to discuss HIV initiatives, (2) forming and participating in national research consortia to promote and disseminate HIV research, and (3) mentoring and promoting the careers of junior investigators. Through these activities, WG3 will promote the following Specific Aims: • To develop new interactions among investigators from various disciplines. Key scientific priorities are: • To stimulate the formation of multi-investigator projects. WG2 success will be defined by the advancement of new collaborative projects, including: • To stimulate cross-fertilization between working groups. In summary, WG3 is focused on promoting key scientific priorities for HIV research in the ART era. This agenda will be supported through targeted activities designed to foster collaborations within the CWRU/UH CFAR, develop supporting resources in the CFAR Cores, especially the Clinical Core D and Uganda Laboratory Core C. The WG3 has placed emphasis on engaging new investigators and has an excellent record of supporting the work of Mentored Scientist Pilot Grant and Catalytic Fund awardees.

尽管抗逆转录病毒治疗 (ART) 对 HIV 感染的预后有显着的改善作用， 提高了患者的生存率，受感染的患者继续遭受结核病的显着发病率和死亡率， CVD、恶性肿瘤、慢性肾脏病和神经认知疾病这些问题凸显了一个事实，即 ART 的同时。 在限制病毒复制方面非常有效，迫切需要解决合并症的决定因素， 这是艾滋病毒研究的关键问题，也是第三工作组议程的重点。 该小组的职责是为 CFAR 确定该领域的科学优先事项，然后促进该领域的进展 通过促进协同互动和合作研究提案并推进职业生涯 工作组有 23 名初级研究者，其中包括大量的临床和转化人员。 在上一个资助周期内总共发表了 423 篇同行评审出版物的研究人员。 WG3 的主要目标是促进 CWRU 及其他研究人员之间的互动与合作 揭示艾滋病毒感染的生物学共病状况。 WG3 通过各种活动促进这一科学议程，包括 (1) 促进协作 通过赞助研讨会、期刊俱乐部、正在进行的研究会议和有针对性的会议来开展研究 讨论艾滋病毒倡议，(2) 组建并参与国家研究联盟以促进和传播 HIV 研究，以及 (3) 指导和促进初级研究人员的职业发展，WG3。 将促进以下具体目标： •● 发展不同学科的研究人员之间的新互动。 优先事项是： •• 刺激多研究者项目的形成将由WG2 来定义。 推进新的合作项目，包括： •• 促进工作组之间的交流。 总之，WG3 的重点是促进 ART 时代艾滋病毒研究的关键科学优先事项。 将通过旨在促进 CWRU/UH 内部合作的有针对性的活动来支持议程 CFAR，开发 CFAR 核心的支持资源，特别是临床核心 D 和乌干达实验室 核心 C. WG3 重点关注新研究者的参与，并在支持方面有着出色的记录 导师科学家试点补助金和催化基金获奖者的工作。