NABTT-Consortium Therapeutic Studies of CNS Malignancies

NABTT-中枢神经系统恶性肿瘤治疗研究联盟

• 批准号: 7478105
• 负责人: STUART A GROSSMAN
• 金额: $ 65.55万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-17 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7478105
• 关键词: Adult; Alabama; Biology; Biometry; Brain Neoplasms; Cancer Center; Caring; Clinic; Clinical; Clinical Drug Development; Clinical Trials; Collaborations; Community Clinical Oncology Program; Controlled Study; Data Analyses; General Hospitals; Hospitals; Image; Institution; Laboratories; Malignant Neoplasms; Massachusetts; Medical; Monitor; National Cancer Institute; New Agents; New Approaches to Brain Tumor Therapy Consortium; Numbers; Operative Surgical Procedures; Outcome; Patient Care Team; Peer Review; Pennsylvania; Pharmacologic Substance; Pharmacology; Phase; Quality Control; Quality of life; Research; Research Project Grants; Resources; Route; Scientist; Specimen; Therapeutic; Therapeutic Studies; Universities; Ursidae Family; clinically relevant; data management; design; experience; forest; human data; improved; multidisciplinary; neuro-oncology; neuropathology; neurosurgery; novel; novel strategies; oncology; organizational structure; protocol development; therapy design

DESCRIPTION (provided by applicant): The primary objective of this proposal is to improve the therapeutic outcome for adults with primary brain tumors. The secondary objective is to share clinical and laboratory data and human brain tumor specimens to conduct research pertaining to the basic biology of primary brain tumors, the neuro-pharmacology of novel therapies, and improving the care and quality of life of adults with primary brain tumors. These objectives will be accomplished by conducting Phase I and II clinical trials using promising new agents, biologic approaches, routes of administration, and trial designs for the treatment of primary brain tumors through the continued efforts of the "New Approaches to Brain Tumor Therapy (NABTT) CNS Consortium." This consortium combines and focuses the experience, resources, and capabilities of ten outstanding medical institutions (Cleveland Clinic, Emory University, Henry Ford Hospital, Johns Hopkins University, Massachusetts General Hospital, Moffitt Cancer Center, National Cancer Institute Intramural Neuro-Oncology Program, the University of Alabama at Birmingham, University of Pennsylvania, and Wake Forest University) to bear on primary brain tumors. These participating institutions have (1) a large number of adults with primary brain tumors, (2) expert multidisciplinary clinical teams caring for these patients, (3) extensive clinical, laboratory, and imaging resources, (4) many high quality, clinically relevant, peer-reviewed, clinical and laboratory brain tumor research projects, (5) nationally recognized expertise in oncology, pharmacology, new drug development, clinical trials, neurosurgery, and neuropathology (6) extensive expertise in biostatistics, data management, and the coordination of multi-institutional studies, and (7) exceptional reputations for excellence in clinical care and research. The consortium adds to these institutional strengths with: (1) a formal, comprehensive organizational structure, (2) a stable and smoothly functioning Central Operations Office, (3) outstanding biostatistics, pharmacology, and correlative biology, (4) an emphasis on trial design, protocol development, quality control, study monitoring, and data analysis, and (5) collaborations with pharmaceutical companies, a computing consortium, and other scientists conducting brain tumor research.

描述（由申请人提供）：该提案的主要目的是改善原发性脑肿瘤成年人的治疗结果。次要目标是共享临床和实验室数据以及人脑肿瘤标本，以进行与原发性脑肿瘤的基本生物学有关的研究，新型疗法的神经药理学以及改善原发性脑肿瘤成年人的护理和生活质量。这些目标将通过使用有前途的新药物，生物学方法，给药途径和试验设计进行I阶段和II期临床试验来实现，以通过“新的脑瘤治疗方法（NABTT）CNS联盟的新方法”来治疗原发性脑肿瘤。该财团结合并关注了十个杰出医疗机构的经验，资源和能力（克利夫兰诊所，埃默里大学，亨利·福特医院，约翰·霍普金斯大学，马萨诸塞州霍普金斯大学，莫菲特癌症中心，国家癌症研究所内神经研究所内神经神经学研究所，阿拉巴马大学伯明翰大学伯明翰大学伯明翰大学的阿拉巴马大学，沃克夫妇，沃克夫妇， These participating institutions have (1) a large number of adults with primary brain tumors, (2) expert multidisciplinary clinical teams caring for these patients, (3) extensive clinical, laboratory, and imaging resources, (4) many high quality, clinically relevant, peer-reviewed, clinical and laboratory brain tumor research projects, (5) nationally recognized expertise in oncology, pharmacology, new drug development, clinical trials,神经外科和神经病理学（6）生物统计学，数据管理和多机构研究的协调方面的广泛专业知识，以及（7）在临床护理和研究方面卓越卓越的杰出声誉。该联盟通过以下方式增加了这些机构优势：（1）正式，全面的组织结构，（2）稳定且顺利运转的中央运营办公室（（3）出色的生物统计学，药理学和相关生物学，（4）强调试验，协议开发，质量控制，研究和数据分析，以及（5）与药物合作，以及（5）与药物合作，以及（5）脑图，（5）与药物合作，5） 研究。

项目成果

Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma.

• DOI: 10.1007/s11060-010-0143-7
• 发表时间: 2010-10
• 期刊: Journal of neuro-oncology
• 影响因子: 3.9
• 作者: Phuphanich S;Supko JG;Carson KA;Grossman SA;Burt Nabors L;Mikkelsen T;Lesser G;Rosenfeld S;Desideri S;Olson JJ
• 通讯作者: Olson JJ

Delivery systems and molecular targets of mechanism-based therapies for GBM.

GBM 机制疗法的递送系统和分子靶点。

• DOI: 10.1586/14737175.4.4.649
• 发表时间: 2004
• 期刊: Expert review of neurotherapeutics
• 影响因子: 4.3
• 作者: Phuphanich,Surasak;Brat,DanielJ;Olson,JeffreyJ
• 通讯作者: Olson,JeffreyJ

An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and feasibility trial.

用于治疗复发性恶性神经胶质瘤的充气球囊导管和液体 125I 放射源（GliaSite 放射治疗系统）：多中心安全性和可行性试验。

• DOI: 10.3171/jns.2003.99.2.0297
• 发表时间: 2003
• 期刊: Journal of neurosurgery.
• 作者: Tatter,StephenB;Shaw,EdwardG;Rosenblum,MarkL;Karvelis,KastytisC;Kleinberg,Lawrence;Weingart,Jon;Olson,JeffreyJ;Crocker,IanR;Brem,Steven;Pearlman,JamesL;Fisher,JoyD;Carson,Kathryn;Grossman,StuartA;NewApproachestoBrain
• 通讯作者: NewApproachestoBrain

Suramin and radiotherapy in newly diagnosed glioblastoma: phase 2 NABTT CNS Consortium study.

苏拉明和放射治疗新诊断的胶质母细胞瘤：2 期 NABTT CNS 联盟研究。

• DOI: 10.1215/s1152851703000127
• 发表时间: 2004
• 期刊: Neuro-oncology
• 影响因子: 15.9
• 作者: Laterra,JohnJ;Grossman,StuartA;Carson,KathrynA;Lesser,GlennJ;Hochberg,FredH;Gilbert,MarkR;NABTTCNSConsortiumstudy
• 通讯作者: NABTTCNSConsortiumstudy

Phase I and pharmacokinetic study of COL-3 in patients with recurrent high-grade gliomas.

COL-3 在复发性高级别胶质瘤患者中的 I 期和药代动力学研究。

• DOI: 10.1007/s11060-011-0602-9
• 发表时间: 2011
• 期刊: Journal of neuro-oncology
• 影响因子: 3.9
• 作者: Rudek,MichelleA;New,Pamela;Mikkelsen,Tom;Phuphanich,Surasak;Alavi,JaneB;Nabors,LouisB;Piantadosi,Steven;Fisher,JoyD;Grossman,StuartA
• 通讯作者: Grossman,StuartA