Use of Novel Mobile Technology to Screen Sexual Partners for HIV and STIs

使用新型移动技术筛查性伴侣的艾滋病毒和性传播感染

基本信息

批准号：
9270044
负责人：
Ivan C Balan
金额：
$ 58.05万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-05 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9270044
关键词：
Acquired Immunodeficiency Syndrome Antibodies Anus Balan Behavior Behavioral Biomedical Engineering Blood Blood Tests Caring Cellular Phone Computers Conscious Detection Development Devices Drops Early treatment Electronics Empathy Engineering Epidemic Feedback Frequencies Funding HIV HIV Infections HIV Seropositivity HIV/STD Hand Harm Reduction Health High Risk Woman Home environment Human immunodeficiency virus test Incidence Individual Infection Instruction Intervention Interview Interviewer LIF gene Lead Link Methods Monitor Motivation Newly Diagnosed Participant Phase Phonation Prevention Prevention strategy Recommendation Research Research Personnel Risk Risk Assessment Schools Sex Behavior Sexual Partners Shapes Symptoms Syphilis Technology Telephone Test Result Testing Time Universities Use Effectiveness Visit Work base condoms experience high risk high risk population high risk sexual behavior innovation men men who have sex with men mobile computing monitoring device novel novel strategies pre-exposure prophylaxis prevent public health relevance screening seroconversion sex risk sexual encounter skills social norm tool transgender women transmission process usability

项目摘要

DESCRIPTION (provided by applicant): Increasing incidence of HIV and STIs among men who have sex with men (MSM) and transgender women (TGW) highlight the need for novel approaches to reducing infections-especially among individuals who do not use condoms consistently. Our prior studies on the use of rapid HIV self-testing (ST) by MSM who regularly engage in high-risk sexual behavior, show that these men are willing to use ST with partners, avoid intercourse in situations where partners test HIV-positive, and, over time tend to reduce their high-risk sexual behavior. This proposed study expands this line of research by exploring the use of a new device, the mChip dongle. Developed at the Columbia University School of Engineering, this device uses smartphone technology to analyze a drop of blood and test it for HIV and syphilis antibodies. The mChip dongle brings more precision to ST, tests for HIV and syphilis and potentially other STIs, and can capitalize on smartphone technology to provide clearer user instructions, on-hand information about HIV/STI, remote monitoring of the its use, and linkage of newly diagnosed individuals to care. For this proposed quantitative and qualitative study, we will again focus on HIV-uninfected MSM and TGW with multiple sexual partners who know how to prevent HIV infection, yet engage in high-risk sexual behavior. The Specific Aims are to: 1) Assess acceptability among MSM and TGW of using the mChip dongle to test sexual partners; 2) Optimize the smartphone app and mChip dongle for home use; and 3) Assess the feasibility of using the mChip dongle to test sexual partners, including: a) frequency of use of the mChip dongle with sexual partners over 3 months; b) factors associated with mChip dongle use or non-use; c) condom use with partners who were not screened vs. partners screened HIV or STI- negative with the mChip dongle; and d) factors associated with changes in sexual risk behavior over 3 months. The study consists of two phases. In Phase 1A, 60 participants will undergo a quantitative, qualitative, and skill-demonstration assessment (using the mChip dongle in front of the interviewer) in a single study visit. Phase 1A findings wil inform Phase 1B, which focuses on revising the smartphone app and mChip dongle for home users, as well as revisions to the Phase 2 assessment. In Phase 2A, 80 new participants will undergo a baseline quantitative and skill-demonstration assessment in order to screen for 50 participants who will be invited into the Phase 2B 3-month study. These 50 participants will be provided with an mChip dongle and given the choice to use it to screen sexual partners. After 3 months participants will undergo a quantitative and qualitative interview about experiences using (or not using) the mChip dongle with partners. This study will capitalize on a critical juncture in the development of the mChip dongle by systematically engaging its intended users in offering feedback to the engineering team on how to optimize its usability and acceptability among high-risk populations. This study will also allow us to assess the feasibility of conducting a larger and longer trial to develop and test an mChip-based harm-reduction intervention.

描述（由申请人提供）：男男性行为者 (MSM) 和变性女性 (TGW) 中艾滋病毒和性传播感染的发病率不断上升，凸显了减少感染的新方法的必要性，特别是对于不经常使用安全套的个人。先前关于经常进行高风险性行为的 MSM 使用快速艾滋病毒自我检测 (ST) 的研究表明，这些男性愿意与伴侣一起使用 ST，避免在伴侣检测出艾滋病毒呈阳性的情况下发生性行为，并且,随着时间的推移，他们的高风险性行为往往会减少。这项拟议的研究通过探索哥伦比亚大学工程学院开发的新设备 mChip 加密狗的使用来扩展这一研究范围，该设备使用智能手机技术来分析性行为。 mChip 适配器为 ST、HIV 和梅毒以及潜在的其他性传播感染检测带来了更高的精确度，并且可以利用智能手机技术提供更清晰的用户说明和有关相关信息。 HIV/STI、其使用的远程监测以及新诊断个体与护理的联系对于这项拟议的定量和定性研究，我们将再次关注具有多个知道如何预防 HIV 感染的性伴侣的 HIV 感染的 MSM 和 TGW。，但从事高风险性行为的具体目标是： 1) 评估 MSM 和 TGW 对使用 mChip 加密狗测试性伴侣的接受程度； 2) 优化智能手机应用程序和 mChip 加密狗。 3) 评估使用 mChip 加密狗测试性伴侣的可行性，包括： a) 超过 3 个月与性伴侣使用 mChip 加密狗的频率； b) 与使用或不使用 mChip 加密狗相关的因素； c) 未接受筛查的伴侣与通过 mChip 加密狗筛查出 HIV 或 STI 阴性的伴侣使用安全套；以及 d) 与 3 个月内性危险行为变化相关的因素该研究分为两个阶段。在 1A 阶段，60 名参与者将在一次研究访问中接受定量、定性和技能演示评估（在面试官面前使用 mChip 加密狗），1A 阶段的结果将为 1B 阶段提供信息，该阶段的重点是修改智能手机应用程序。和面向家庭用户的 mChip 加密狗，以及对第 2 阶段评估的修订在第 2A 阶段，80 名新参与者将接受基线定量和技能演示评估，以进行筛选。将邀请 50 名参与者参加为期 3 个月的 2B 期研究。这 50 名参与者将获得一个 mChip 加密狗，并可以选择使用它来筛选性伴侣。 3 个月后，参与者将接受有关性伴侣的定量和定性访谈。与合作伙伴一起使用（或不使用）mChip 加密狗的经验本研究将利用 mChip 加密狗开发的关键时刻，系统地吸引目标用户向工程团队提供有关如何优化其可用性的反馈。这项研究还将使我们能够评估进行更大规模、更长时间的试验来开发和测试基于 mChip 的减害干预措施的可行性。