Hedgehog signaling and signal transduction

Hedgehog信号传导和信号转导

基本信息

批准号：
9193088
负责人：
THOMAS B. KORNBERG
金额：
$ 30.12万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-15 至 2018-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9193088
关键词：
Alleles Animals Area Bacterial Artificial Chromosomes Behavior Biology C-terminal Caliber Cell Line Cells Cholesterol Clinical Trials Colon Carcinoma Data Development Disease Drug or chemical Tissue Distribution Erinaceidae Genetic Hematologic Neoplasms Homeostasis Image Invertebrates Learning Length Life Location Malignant Neoplasms Malignant neoplasm of brain Malignant neoplasm of lung Malignant neoplasm of pancreas Malignant neoplasm of prostate Measures Methods Monitor Movement Organ Output Palmitates Pathway interactions Physiological Play Process Production Proteins Publishing RNA Interference Reagent Regimen Regulation Resistance Resolution Role Signal Transduction Skin Cancer Stem cells System Therapeutic Time Tissues Transgenes Vertebrates Work body system cancer therapy chemotherapy fly hedgehog signal transduction improved knock-down malignant breast neoplasm mutant overexpression pancreatic cancer cells public health relevance response smoothened signaling pathway tool transcription factor

项目摘要

DESCRIPTION (provided by applicant): Hedgehog signaling has been implicated in many cancers and has been shown to be a useful target for anti-cancer therapy. Previous work, including key contributions from my lab, have established that the Hedgehog protein is one of the major regulators of animal development, playing key roles in most tissues and organs in both invertebrates and vertebrates. Using newly developed reagents and methods that open new ways to study Hh signaling, the work proposed in this application will identify and characterize the processes that Hh-producing cells use to prepare and deliver Hh protein, the processes that Hh-receiving cells use to prepare for and handle its arrival, and the processes that regulate the form and activity of Ci, the transcription factor that is responsible for Hh pathway output. These issues are critical to understanding how new and better therapeutic regimens controlling Hh activity can be developed.

描述（由申请人提供）：Hedgehog 信号转导与许多癌症有关，并且已被证明是抗癌治疗的有用靶标。之前的工作，包括我实验室的重要贡献，已经确定刺猬蛋白是动物发育的主要调节因子之一，在无脊椎动物和脊椎动物的大多数组织和器官中发挥着关键作用。使用新开发的试剂和方法，开辟了研究 Hh 信号传导的新方法，本申请中提出的工作将鉴定和表征 Hh 产生细胞用于制备和递送 Hh 蛋白的过程，以及 Hh 接收细胞用于制备 Hh 蛋白的过程。并处理它的到达，以及调节 Ci 的形式和活性的过程，Ci 是负责 Hh 途径输出的转录因子。这些问题对于理解如何开发新的、更好的控制 Hh 活性的治疗方案至关重要。