ShEEP Request for Heidelberg Spectralis Tracking OCT System - HRA+OCT with OCT2 Multicolor

ShEEP 请求海德堡 Spectralis 跟踪 OCT 系统 - HRA OCT 与 OCT2 多色

• 批准号: 9362000
• 负责人: Matthew M. Harper
• 金额: --
• 依托单位: IOWA CITY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9362000
• 关键词: Achievement; Affect; Algorithmic Analysis; Angiography; Animals; Blindness; Choroid; Cities; Collection; Complications of Diabetes Mellitus; Computer software; Cornea; Country; Disease; Dyes; Engineering; Ensure; Equipment; Experimental Models; Eye; Functional disorder; Funding; Generations; Glaucoma; Health; Healthcare; Image; Image Analysis; Injectable; Iowa; Mus; Optical Coherence Tomography; POU2F2 gene; Patients; Perfusion; Prevention; Program Evaluation; Radiation; Request for Applications; Research; Research Personnel; Retina; Retinal; Retinal Diseases; Scanning; Sheep; Stress; Structure; System; Technology; Traumatic Brain Injury; Veterans; Vision research; Visual; imaging capabilities; improved; in vivo; instrument; interest; mitochondrial dysfunction; multidisciplinary; programs; retinal damage; treatment response

With this application we request funds from the ORD Shared Equipment Evaluation Program (SHEEP) to purchase a new generation Optical Coherence Tomography (OCT) unit with OCT- angiography (OCT-A) capabilities. Specifically, we seek to obtain a Heidelberg Engineering Spectralis Tracking OCT System - HRA+OCT w/OCT2 – MultiColor and Heidelberg Engineering Widefield Imaging Module. This instrument will be shared among investigators within the Department of Veterans Affairs Center for the Prevention and Treatment of Visual Loss (CPTVL). The rationale for our purchase is twofold. First, our current OCT, a Heidelberg Engineering HRA-OCT is becoming outdated and cannot be upgraded to a newer OCT-A mode. Second, the new version of the Spectralis HRA-OCT instrument offers several scientific advantages over the older version, which include the ability to image retinal vasculature without the need to inject dye into the animal. The investigators that are submitting this proposal are all investigators within the Iowa City VA Center for the Prevention and Treatment of Visual Loss. All investigators are interested in discovering the causes of various forms of visual loss and developing new treatments for visual loss to help affected Veterans. The research portfolio of investigators within with proposal is diverse with respect to visual loss. These include radiation-induced retinal damage, glaucoma, visual loss related to traumatic brain injury, mitochondrial dysfunction, retinal complications of diabetes, outer retinal visual loss, image analysis of retinal diseases and corneal damage and dysfunction. Thus, acquisition of a Heidelberg Spectralis HRA+OCT with OCT-A and Multicolor analysis will enhance the ability of investigators at the Iowa City VA to determine the causes of visual loss in mice through retinal imaging. This instrument will also integrate seamlessly with our multi-disciplinary image analysis team, which will allow us to extract a maximum amount of information from each animal subject.

通过此申请，我们向 ORD 共享设备评估计划请求资金 (SHEEP) 购买新一代光学相干断层扫描 (OCT) 设备，配备 OCT- 具体来说，我们寻求获得海德堡工程 Spectralis 的能力。 跟踪 OCT 系统 - HRA+OCT w/OCT2 – MultiColor 和 Heidelberg Engineering Widefield 该仪器将在部门内的研究人员之间共享。 退伍军人事务中心预防和治疗视力丧失 (CTVL)。 我们购买的理由是双重的。 首先，我们目前的 OCT（海德堡工程 HRA-OCT）已经过时，无法再使用。 二、新版Spectralis HRA-OCT仪器升级为更新的OCT-A模式。 与旧版本相比，它具有多项科学优势，其中包括视网膜成像的能力 脉管系统，无需将染料注射到动物体内。 提交此提案的调查员都是爱荷华市退伍军人事务部中心的调查员 所有研究人员都对发现视力丧失感兴趣。 各种形式的视力丧失的原因，并开发新的视力丧失治疗方法以帮助受影响的人 退伍军人的提案中的研究人员的研究组合在视觉方面是多种多样的。 这些包括辐射引起的视网膜损伤、青光眼、与脑外伤相关的视力丧失。 损伤、线粒体功能障碍、糖尿病视网膜并发症、外视网膜视力丧失、图像 分析视网膜疾病和角膜损伤和功能障碍。 因此，购买具有 OCT-A 和多色分析功能的 Heidelberg Spectralis HRA+OCT 将 增强爱荷华市退伍军人管理局研究人员确定小鼠视力丧失原因的能力 通过视网膜成像，该仪器还将与我们的多学科无缝集成。 图像分析团队，这将使我们能够从每个图像中提取最大量的信息 动物主题。