Components of Ras-Mediated Growth Control

Ras 介导的生长控制的组成部分

• 批准号: 7348408
• 负责人: MICHAEL A. WHITE
• 金额: $ 26.14万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7348408
• 关键词: Cell Cycle Progression; Cell Proliferation; Cell Survival; Cell physiology; Cells; Cellular Structures; Coupling; Cyclins; Epithelial Cells; Family; Generations; Goals; Growth; Guanosine Triphosphate Phosphohydrolases; Human; MAP Kinase Modules; MEKs; Malignant Neoplasms; Mediating; Molecular; Monomeric GTP-Binding Proteins; Oncogenic; Pathway interactions; Phosphotransferases; Protein Family; Proteins; Regulation; Research Project Grants; Response to stimulus physiology; Role; Scaffolding Protein; Signal Transduction; Stimulus; System; Tumor Suppressor Proteins; base; cancer cell; cell transformation; defined contribution; neoplastic cell; programs; receptor; response

Ras family GTPases are critical components of cell regulatory systems that control proliferation, differentiation, and cell survival. Inappropriate regulation of these systems directly contributes to initiation and progression of human cancer. This proposal is directed at increasing our understanding of the composition, organization, and function of cell regulatory networks engaged by Ras family GTPases. Our focus is on the dominant effector pathways that mediate oncogenic Ras-induced cell transformation. Our specific aims are 1) revealing the molecular basis of the contribution of Ral GTPases to support of human tumor cell proliferation and survival; 2) assessing the role of two candidate Ras effectors in limiting cellular responses to mitogenic signals; and 3) defining the contribution of scaffolding proteins to the generation of signal fidelity on the ERK1/2 MAP kinase cascade..

RAS家族GTPases是控制增殖的细胞调节系统的关键组成部分， 分化和细胞存活。这些系统的不适当调节直接有助于启动 和人类癌症的进展。该建议是针对我们对 RAS家族GTPases参与的细胞调节网络的组成，组织和功能。我们的 重点是介导致癌Ras诱导的细胞转化的主要效应途径。我们的 具体目的是1）揭示RAL GTPases对人类支持的贡献的分子基础 肿瘤细胞增殖和存活； 2）评估两个候选RAS效应子在限制细胞中的作用 对有丝分裂信号的响应； 3）定义脚手架蛋白对产生的贡献 ERK1/2 MAP激酶级联的信号保真度。