Delineating the kidney brain axis in children with severe malaria (KID-BRAIN)

描绘严重疟疾儿童的肾脑轴（KID-BRAIN）

• 批准号: 10734142
• 负责人: Anthony Batte
• 金额: $ 9.65万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-20 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10734142
• 关键词: Acute; Acute Renal Failure with Renal Papillary Necrosis; Address; African; Award; Biological Markers; Brain; Brain Edema; Brain Injuries; Brain imaging; Cell Cycle Arrest; Cerebral Edema; Child; Childhood; Childhood Injury; Chronic Kidney Failure; Clinical; Coma; Communities; Creatinine; Data; Data Analyses; Detection; Development; Development Plans; Diagnosis; Endothelium; Epidemiology; Evaluation; Fever; Filtration; Fogarty International Center; Funding; Future; Goals; Growth and Development function; Health Sciences; Hospitalization; Image Analysis; Injury; Injury to Kidney; Intervention; Intervention Studies; Kidney; Kidney Diseases; Knowledge; Lead; Learning; Link; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Malaria; Malnutrition; Mentors; National Institute of Neurological Disorders and Stroke; Neuroglia; Neurological outcome; Observational Study; Osmolar Concentration; Outcome; Pathogenesis; Pathway interactions; Patients; Phenotype; Physicians; Plasma; Population; Positioning Attribute; Problem behavior; Publishing; Recovery; Research; Research Personnel; Research Training; Risk Factors; Sampling; Scientist; Serum; Sickle Cell Anemia; Site; Stress; Stroke; Structure; Teacher Professional Development; Testing; Time; Training; Translating; United States National Institutes of Health; Universities; Urea; Work; biosignature; blood-brain barrier disruption; brain health; career; career development; cell injury; clinical diagnosis; college; disability; early childhood; education planning; evidence base; follow-up; immune activation; improved; lecturer; mortality; neurobehavioral; point of care testing; predictive marker; prevent; prospective; skills; tool

Project summary/ abstract The overall goal of this career award is to build Dr Batte into an independently funded physician scientist improving survival of children with acute kidney injury (AKI) and identify interventions that will enable children to thrive. Dr Batte will delineate mechanisms of kidney-related brain injury in children with severe malaria. Dr Batte is a Lecturer and a Pediatric nephrologist at Makerere University college of health sciences. From his past research work, he has established evidence-based approaches to AKI diagnosis and phenotypic characterization. He has explored the utility of point-of-care tests in evaluating AKI, and has mechanistically compared severe malaria AKI and non-malaria febrile illnesses related AKI demonstrating differences in endothelial activation and immune activation. He has also evaluated brain injury and neurological outcomes of children with AKI following acute malnutrition and sickle cell anemia. He has published an invited review highlighting challenges in the diagnosis and management of AKI in children and outlined priorities for future research, which included detailed neuro-developmental assessments following AKI in children with severe malaria. Dr Batte will use the 75% protected time for the next 5 years working with his mentors to understand how acute changes in brain-kidney crosstalk translate to long-term injury and to identify modifiable pathways amenable to intervention to promote adaptive kidney and brain recovery following severe malaria. Dr Batte has developed an educational plan that builds on his past training and addresses research training gaps, that once filled will provide the basis to propel him into an independent research career. This K43 will be structured around specialized training in neurobehavioral evaluation along with biomarker testing and interpretation. It will help Dr Batte to achieve his objectives which are to; (1) determine the extent that AKI phenotypes are associated with biosignatures of brain injury and recovery (2) establish the extent that AKI and AKI phenotypes are associated with cerebral edema (3) define the association between neurobehavioral outcomes, brain injury biomarkers and AKI phenotypes. Dr Batte will attain a number of skill-sets in kidney and brain biomarker testing and interpretation, skills in brain imaging interpretation, data analysis and conduct of longitudinal studies, and neurobehavioral evaluation of children. It is expected that at completion of this award, with the developed expertise and data generated, he will elucidate modifiable pathways of kidney-brain cross talk in severe malaria, setting the stage for an R01 application and a platform for future intervention studies to prevent injury and promote brain and kidney recovery following severe malaria.

项目摘要/摘要 该职业生涯奖的总体目标是将蝙蝠侠博士建成一位独立资助的医师科学家 改善急性肾脏损伤（AKI）儿童的生存率，并确定将启用的干预措施 孩子们壮成长。 Batte博士将描述严重患者的肾脏相关脑损伤机制 疟疾。 Batte博士是Makerere大学卫生学院的讲师和儿科肾脏科医生 科学。从他过去的研究工作中，他建立了基于证据的AKI诊断方法 和表型表征。他探索了评估AKI的即时测试的实用性，并具有 机械学上比较了严重的疟疾AKI和非麦芽菌，与AKI有关 内皮激活和免疫激活的差异。他还评估了脑损伤和 急性营养不良和镰状细胞贫血后，患有AKI的儿童的神经学结局。他有 发表了一份邀请的评论，强调了儿童AKI诊断和管理的挑战 概述了未来研究的优先事项，其中包括详细的神经开发评估 Aki患有严重疟疾的儿童。 Batte博士将在接下来的5年中使用75％的保护时间 伴随着他的导师，了解脑部 - kidney Crosstalk的急性变化如何转化为长期伤害 并确定可修改的途径，可促进干预以促进自适应肾脏和大脑 严重疟疾后的恢复。 Batte博士制定了一项教育计划，以他的过去为基础 培训并解决研究培训差距，曾经填补的培训差距将提供基础，以推动他进入 独立研究职业。该K43将围绕神经行为的专业培训进行结构 评估以及生物标志物测试和解释。它将帮助蝙蝠侠实现他的目标 是（1）确定AKI表型与脑损伤的生物签名有关的程度 恢复（2）确定了AKI和AKI表型与脑水肿相关的程度（3） 定义神经行为结局，脑损伤生物标志物和AKI表型之间的关联。博士 Batte将获得许多在肾脏和脑生物标志物测试和解释的技能，大脑的技能 成像解释，数据分析和纵向研究的进行以及神经行为评估 孩子们。预计该奖项完成后，随着已发达的专业知识和数据生成的数据 他将在严重疟疾中阐明肾脑横切的可修改途径，为 R01应用和将来干预研究的平台，以防止受伤和促进大脑， 严重疟疾后的肾脏恢复。