Stressors, Sleep, and Cognitive Function among Asian Americans

亚裔美国人的压力源、睡眠和认知功能

• 批准号: 10726414
• 负责人: SUNMIN LEE
• 金额: $ 41.76万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-08 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10726414
• 关键词: Affect; African American population; Age; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; American Indians; Asian Americans; Behavioral; Biological; Black Populations; Body mass index; COVID-19; California; Cause of Death; Cessation of life; Chinese; Chronic Disease; Data; Diagnosis; Diagnostic; Discrimination; Disease; Disparity; Drowsiness; Education; Episodic memory; Evaluation; Excess Mortality; Family Caregiver; Health; High Prevalence; Hispanic Populations; Immigrant; Impaired cognition; Incidence; Income; Individual; Inflammation; Intervention; Investigation; Japanese American; Koreans; Life Stress; Link; Longitudinal Studies; Mediating; Medical Records; Medicare; Modeling; Not Hispanic or Latino; Pacific Islander; Parents; Participant; Patient Self-Report; Persons; Polysomnography; Population; Prevalence; Refugees; Reporting; Research; Risk; Risk Factors; Shapes; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Social Processes; Stress; Stressful Event; Subgroup; Symptoms; Testing; Time; Vietnamese; anti-Asian; beneficiary; biopsychosocial; cardiometabolic risk; cognitive function; cognitive testing; dementia risk; design; ethnic minority; experience; health care service utilization; information processing; innovation; memory process; men; mild cognitive impairment; minority stress; mortality; neighborhood disadvantage; perceived discrimination; poor sleep; processing speed; psychologic; psychological distress; racial minority; racism; sex; sleep pattern; sleep quality; stressor; systematic review; tool; traumatic stress; trend; β-amyloid burden

PROJECT SUMMARY / ABSTRACT The Asian American population is rapidly growing and will be the largest immigrant group by 2065. Alzheimer's Disease and Related Dementias (ADRD) is the fastest-growing cause of death for Asian Americans in California, and are likely to increase as the number of U.S. deaths from Alzheimer's disease between 2000-2017 has increased by 145%. During COVID-19, Asian American Medicare beneficiaries with ADRD faced greater excess mortality compared to their non-Hispanic White counterparts. The number of Californian Asian Americans living with ADRD will more than double by 2040, totaling more than 241,000. The ADRD incidence, prevalence, and mortality data for Asian Americans are underestimated because Asian Americans may not report ADRD symptoms unless family caregivers require assistance with behavioral issues, and Asian Americans receive fewer diagnostic evaluations and do not receive timely diagnoses compared to non-Hispanic Whites. Stressful experiences such as discrimination and cumulative life stress increase cognitive impairment or ADRD, however, data are sparse among Asian Americans. Poor sleep has been associated with CI and ADRD through mechanisms such as inflammation increasing β-amyloid burden, although data are lacking in the understudied Asian American population. This study builds on the biopsychosocial model of health and disease, which posits that biological, psychological, and social processes interactively shape health and illness within individuals, and subgroups of the population. Data for the proposed study will be collected as a part of the parent longitudinal R01 study examining associations among immigrant stressors, sleep, and cardiometabolic risks in 750 Chines, Korean, and Vietnamese Americans residing in Southern California. In the proposed supplement study, we will add a 10- minute global cognitive function examination tool (the Montreal Cognitive Assessment (MoCA)) to the parent study and collect data from 50 Chinese, 50 Korean, and 50 Vietnamese participants who are 60 ≥ years old and already participating in the parent study. This innovative supplement study will be one of the first studies to examine the interplay of immigrant stressors, sleep, and cognitive function among Asian Americans. Findings from this study will contribute to designing a larger-scale longitudinal study to examine in-depth causal associations and identify modifiable targets for intervention to reduce sleep and ADRD disparities in understudied Asian Americans. Relevance to ADRD: Both specific aims of the proposed application focus on examining predictors of cognitive function using a validated assessment for detecting mild cognitive impairment, a precursor to ADRD.

项目摘要 /摘要 亚裔美国人人口正在迅速增长，到2065年将成为最大的移民群体。阿尔茨海默氏症 疾病和相关痴呆症（ADRD）是加利福尼亚亚裔美国人的死亡原因最快的原因， 并且随着2000 - 2017年之间美国阿尔茨海默氏病死亡的美国死亡人数的数量可能会增加 增加了145％。在Covid-19期间，ADRD的亚裔美国医疗保险受益人面临更大的超过 与非西班牙裔白人同行相比，死亡率。居住的加利福尼亚亚裔美国人人数 到2040年，ADRD将翻一番以上，总计超过241,000。 Adrd事件，患病率和 亚裔美国人的死亡率数据被低估了，因为亚裔美国人可能不会报告ADRD 症状除非家庭护理人员需要在行为问题上提供帮助，而亚裔美国人则接受 与非西班牙裔白人相比，诊断评估较少，并且没有及时诊断。 歧视和累积生活压力等压力经历会增加认知障碍或ADRD， 但是，亚裔美国人的数据很少。睡眠不佳与CI和ADRD有关 尽管缺乏可理解的数据，但炎症等机制增加了β-酰化 亚裔美国人。 这项研究以健康和疾病的生物心理社会模型为基础，该模型认为生物学，心理学， 社会过程在交互作用塑造个人内部的健康和疾病，以及人口的亚组。 拟议研究的数据将作为父母纵向R01研究的一部分收集 750 Chinas，韩国人和移民压力源，睡眠和心脏代谢风险之间的关联 居住在南加州的越南美国人。在拟议的补充研究中，我们将添加10- 分钟全球认知功能检查工具（蒙特利尔认知评估（MOCA））给父母 研究和收集来自50名中国人，50名韩语和50名越南参与者的数据，他们有60≥年来， 已经参加了家长研究。 这项创新的补充研究将是最早研究移民压力源相互作用的研究之一， 亚裔美国人的睡眠和认知功能。这项研究的发现将有助于设计 大规模的纵向研究，以检查深入的因果关系并确定可修改的目标 干预以减少理解的亚裔美国人的睡眠和ADRD差异。 与ADRD的相关性：拟议应用程序的两个具体目的都侧重于检查认知的预测指标 使用经过验证的评估来检测轻度认知障碍的功能，这是ADRD的前身。