Stressors, Sleep, and Cognitive Function among Asian Americans

亚裔美国人的压力源、睡眠和认知功能

基本信息

批准号：
10726414
负责人：
SUNMIN LEE
金额：
$ 41.76万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-08 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10726414
关键词：
Affect African American population Age Alaska Native Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American American Indians Asian Americans Behavioral Biological Black Populations Body mass index COVID-19 California Cause of Death Cessation of life Chinese Chronic Disease Data Diagnosis Diagnostic Discrimination Disease Disparity Drowsiness Education Episodic memory Evaluation Excess Mortality Family Caregiver Health High Prevalence Hispanic Populations Immigrant Impaired cognition Incidence Income Individual Inflammation Intervention Investigation Japanese American Koreans Life Stress Link Longitudinal Studies Mediating Medical Records Medicare Modeling Not Hispanic or Latino Pacific Islander Parents Participant Patient Self-Report Persons Polysomnography Population Prevalence Refugees Reporting Research Risk Risk Factors Shapes Sleep Sleep Apnea Syndromes Sleep Disorders Social Processes Stress Stressful Event Subgroup Symptoms Testing Time Vietnamese anti-Asian beneficiary biopsychosocial cardiometabolic risk cognitive function cognitive testing dementia risk design ethnic minority experience health care service utilization information processing innovation memory process men mild cognitive impairment minority stress mortality neighborhood disadvantage perceived discrimination poor sleep processing speed psychologic psychological distress racial minority racism sex sleep pattern sleep quality stressor systematic review tool traumatic stress trend β-amyloid burden

项目摘要

PROJECT SUMMARY / ABSTRACT The Asian American population is rapidly growing and will be the largest immigrant group by 2065. Alzheimer's Disease and Related Dementias (ADRD) is the fastest-growing cause of death for Asian Americans in California, and are likely to increase as the number of U.S. deaths from Alzheimer's disease between 2000-2017 has increased by 145%. During COVID-19, Asian American Medicare beneficiaries with ADRD faced greater excess mortality compared to their non-Hispanic White counterparts. The number of Californian Asian Americans living with ADRD will more than double by 2040, totaling more than 241,000. The ADRD incidence, prevalence, and mortality data for Asian Americans are underestimated because Asian Americans may not report ADRD symptoms unless family caregivers require assistance with behavioral issues, and Asian Americans receive fewer diagnostic evaluations and do not receive timely diagnoses compared to non-Hispanic Whites. Stressful experiences such as discrimination and cumulative life stress increase cognitive impairment or ADRD, however, data are sparse among Asian Americans. Poor sleep has been associated with CI and ADRD through mechanisms such as inflammation increasing β-amyloid burden, although data are lacking in the understudied Asian American population. This study builds on the biopsychosocial model of health and disease, which posits that biological, psychological, and social processes interactively shape health and illness within individuals, and subgroups of the population. Data for the proposed study will be collected as a part of the parent longitudinal R01 study examining associations among immigrant stressors, sleep, and cardiometabolic risks in 750 Chines, Korean, and Vietnamese Americans residing in Southern California. In the proposed supplement study, we will add a 10- minute global cognitive function examination tool (the Montreal Cognitive Assessment (MoCA)) to the parent study and collect data from 50 Chinese, 50 Korean, and 50 Vietnamese participants who are 60 ≥ years old and already participating in the parent study. This innovative supplement study will be one of the first studies to examine the interplay of immigrant stressors, sleep, and cognitive function among Asian Americans. Findings from this study will contribute to designing a larger-scale longitudinal study to examine in-depth causal associations and identify modifiable targets for intervention to reduce sleep and ADRD disparities in understudied Asian Americans. Relevance to ADRD: Both specific aims of the proposed application focus on examining predictors of cognitive function using a validated assessment for detecting mild cognitive impairment, a precursor to ADRD.

项目概要/摘要亚裔美国人人口正在快速增长，到 2065 年将成为最大的移民群体。阿尔茨海默病疾病及相关痴呆症 (ADRD) 是加州亚裔美国人死亡增长最快的原因，随着 2000 年至 2017 年间美国因阿尔茨海默病死亡的人数增加，这一数字可能还会增加在 COVID-19 期间，患有 ADRD 的亚裔美国人医疗保险受益人面临着更大的超额。与非西班牙裔白人邻居相比的死亡率加利福尼亚州亚裔美国人的居住人数。到 2040 年，ADRD 的发病率、患病率和患病率将增加一倍以上，总数超过 241,000 例。亚裔美国人的死亡率数据被低估，因为亚裔美国人可能不会报告 ADRD 除非家庭照顾者需要行为问题方面的帮助，并且亚裔美国人接受与非西班牙裔白人相比，他们的诊断评估较少，并且无法及时得到诊断。歧视和累积的生活压力等压力经历会增加认知障碍或ADRD，然而，亚裔美国人的睡眠质量不佳与 CI 和 ADRD 相关的数据很少。炎症增加 β-淀粉样蛋白负担等机制，尽管缺乏充分研究的数据亚裔美国人人口。这项研究建立在健康和疾病的生物心理社会模型的基础上，该模型假设生物、心理、社会进程相互作用地影响个人和人口亚群体的健康和疾病。拟议研究的数据将作为父纵向 R01 研究的一部分进行收集研究人员对 750 名中国、韩国和日本人的移民压力源、睡眠和心脏代谢风险之间的关联进行了研究。居住在南加州的越南裔美国人在拟议的补充研究中，我们将添加 10- 给家长分钟的全球认知功能检查工具（蒙特利尔认知评估（MoCA））研究并收集了 50 名中国人、50 名韩国人和 50 名越南人的参与者的数据，他们的年龄都在 60 岁以上，已经参加家长研究。这项创新的补充研究将是首批研究移民压力源相互作用的研究之一，这项研究的结果将有助于设计一个亚裔美国人的睡眠和认知功能。更大规模的纵向研究，以检查深入的因果关系并确定可修改的目标旨在减少亚裔美国人睡眠和 ADRD 差异的干预措施。与 ADRD 的相关性：所提出的应用程序的两个具体目标都集中在检查认知预测因素使用经过验证的评估来检测轻度认知障碍（ADRD 的先兆）。