Multimodality virtual endoscopy with hybrid PET/CT units

使用混合 PET/CT 设备的多模态虚拟内窥镜检查

• 批准号: 7232466
• 负责人: LUC M BIDAUT
• 金额: $ 13.93万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-15 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7232466
• 关键词: Abbreviations; Appendix; Belief; Biopsy; Bronchial Tree; Bronchoscopy; Cancer Intervention; Cancerous; Chest; Clinical; Clinical Trials; Colon; Colonoscopy; Communication; Complement; Computed Tomographic Colonography; Computer Assisted; Computer software; Computers; Data; Data Set; Development; Diagnosis; Diagnostic Neoplasm Staging; Endoscopes; Endoscopy; Environment; Evaluation; Excision; Exhibits; Feedback; Genus Cola; Glossary; Glucose; Hybrids; Image; Imagery; Institution; Intervention; Invasive; Language; Letters; Life; Lung; Magnetic Resonance; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of thorax; Manufacturer Name; Medical; Medicine; Metabolic; Metabolism; Modality; Modeling; Motion; Multimodal Imaging; Numbers; Organ; Physiology; Picture Archiving and Communication System; Positron-Emission Tomography; Preparation; Procedures; Process; Protocols documentation; Purpose; Radiation therapy; Radiology Specialty; Research; Research Ethics Committees; Research Personnel; Resolution; Safety; Software Tools; Staging; Standards of Weights and Measures; Structure; Surface; System; Techniques; Technology; Tissues; Tracer; Ultrasonography; Virtual Endoscopy; X-Ray Computed Tomography; base; cancer diagnosis; clinical application; concept; density; diagnostic accuracy; digital imaging; fitness; glucose analog; graphical user interface; image processing; improved; lymph nodes; multidisciplinary; novel; optical fiber; pre-clinical; programs; research clinical testing; respiratory; size; tool; tool development; tumor; uptake; virtual; virtual reality

DESCRIPTION (provided by applicant): Endoscopy is an invasive procedure in which a flexible optical fiber (the endoscope) is used for visually inspecting the inner lining of organs such as the airways (bronchoscopy) or the colon (colonoscopy). Virtual endoscopy (VE) uses computed tomography (CT) or magnetic resonance (MR) data to reconstruct and display airway (VB) or colon (VC) surfaces on computers, thereby eliminating the need for the insertion of an endoscope. To date, CT or MR-based virtual endoscopy only examines the surface of the structures. Positron emission tomography (PET) with fluoro-deoxy-glucose (FDG; an analog of glucose) or other tracers can characterize cancerous tissues based on the differentiated metabolism (glycolytic activity for FDG) they exhibit. By combining PET with CT data, we can create a novel modality: PET-augmented virtual endoscopy (PaVE), that offers the anatomical definition provided by CT, but also enables further evaluation for possible malignant involvement based on the glycolytic activity (with FDG) exhibited through PET. Through the clinical integration of new optimized protocols and software tools in a multidisciplinary environment, we aim to improve our ability to effectively combine PET and CT data sets in a VE paradigm with the prospect of increasing diagnostic accuracy and of guiding minimally invasive (Ml) tissue staging procedures such as bronchoscopic transbronchial biopsies and tumor resections for cancers of the chest and lungs. Recently introduced combination PET/CT units that yield both PET and CT data sets in a single study will be instrumental to our proposal. Our institution has been among the very first ones to pioneer the application of these hybrid machines to cancer diagnosis and management, and to further expand their use and accuracy through respiratory gating. The current proposal is therefore a natural complement and extension of this endeavor that conforms to the general purpose of PA-04-045 and especially to topics 3 (image displays and analyses) and 4 (image-guided cancer intervention).

描述（由申请人提供）：内窥镜检查是一种侵入性手术，其中使用柔性光纤（内窥镜）来目视检查器官的内壁，例如气道（支气管镜检查）或结肠（结肠镜检查）。虚拟内窥镜 (VE) 使用计算机断层扫描 (CT) 或磁共振 (MR) 数据在计算机上重建和显示气道 (VB) 或结肠 (VC) 表面，从而无需插入内窥镜。迄今为止，基于 CT 或 MR 的虚拟内窥镜检查仅检查结构的表面。使用氟脱氧葡萄糖（FDG；葡萄糖类似物）或其他示踪剂的正电子发射断层扫描 (PET) 可以根据癌组织表现出的差异化代谢（FDG 的糖酵解活性）来表征癌组织。通过将 PET 与 CT 数据相结合，我们可以创建一种新的模式：PET 增强虚拟内窥镜检查 (PaVE)，它不仅提供 CT 提供的解剖学定义，而且还能够根据糖酵解活性（使用 FDG）进一步评估可能的恶性病变通过PET展示。通过在多学科环境中对新的优化方案和软件工具进行临床整合，我们的目标是提高在 VE 范式中有效结合 PET 和 CT 数据集的能力，以期提高诊断准确性并指导微创 (Ml) 组织分期程序，例如支气管镜经支气管活检和胸部和肺部癌症的肿瘤切除术。最近推出的组合 PET/CT 装置可在一项研究中同时产生 PET 和 CT 数据集，这将有助于我们的建议。我们的机构是最早将这些混合机器应用于癌症诊断和管理的机构之一，并通过呼吸门控进一步扩大其用途和准确性。因此，当前的提案是这一努力的自然补充和延伸，符合 PA-04-045 的一般目的，特别是主题 3（图像显示和分析）和 4（图像引导癌症干预）。