Cardiovascular and HIV/AIDS Effects on Brain Structure/Function and Cognition

心血管和艾滋病毒/艾滋病对大脑结构/功能和认知的影响

基本信息

批准号：
9306744
负责人：
JAMES T. BECKER
金额：
$ 128.66万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9306744
关键词：
AIDS Dementia Complex AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Affect Age Aging American Area Atherosclerosis Behavior Behavioral Biological Assay Bisexual Blood - brain barrier anatomy Blood specimen Brain Brain imaging CCL2 gene Calcium Cardiovascular system Cerebrovascular Circulation Chronic Chronology Clinic Visits Cognition Cognitive Combination Medication Comorbidity Coronary artery Data Deposition Diffusion Disease Enrollment Fibrin fragment D Forced expiratory volume function Functional disorder Gadolinium Gays HIV HIV Infections Health Image Impaired cognition Incidence Individual Infection Inflammation Inflammatory Interferon Type II Interleukin-2 Interleukin-6 Laboratory Study Link MRI Scans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measures Mediating Membrane Metabolic Methodology Modeling Neopterin Neurologic Neuropsychological Tests Neuropsychology Participant Premature aging syndrome Prevalence Process Rage Recruitment Activity Rest Risk Sampling Scanning Series Site Slice Structure Testing The Multicenter AIDS Cohort Study Time Vascular Diseases Virus Virus Replication Visit body system cognitive function cytokine executive function fighting glial activation gray matter inflammatory marker instrument intimal medial thickening longitudinal analysis men normal aging primary outcome public health relevance spectrograph tractography virtual white matter

项目摘要

DESCRIPTION (provided by applicant): The prevalence of HIV-related cognitive dysfunction remain high, and non-HIV-associated factors are now significant risk modifiers for cognitive impairment and alterations in brain structure. Perhaps most important factor related to the health of Americans with HIV disease is aging. The infection (and its consequences) appear to alter the normal age trajectories of structure or function in virtually all organ systems. In additon to the "normal" comorbidities that occur in individuals >50 years old, a chronic infection may result in significant burden to the brain, resulting in alterations in cognition and behavior. This concern is confounded by the fact that many individuals >50 years old currently alive with HIV disease were infected during the 1980/90s and endured years of uncontrolled or poorly controlled viral replication. During this five-year renewal period (AG034852), we will expand our current sample to 400 men with an additional 70 men >60 years old. They will undergo two scanning/testing sessions two years apart, resulting in a sample of 350 men with at least two scans, and as many as 280 men with four scans over 13 years. The brain imaging methodologies will assess the integrity of brain gray and white matter and the integrity of brain functional networks, tractography, metabolites, cerebral blood flow, and the integrity of the blood brain barrier. We will utilize these data, in combination with the 15-30 years of prior information from the Multicenter AIDS Cohort Study to evaluate the relative merits of a general conceptual model of the factors associated with the expression of cognitive and behavioral abnormalities in HIV Disease. We will complete detailed longitudinal analyses of the relationships between markers of subclinical vascular disease, inflammation, brain structure and cognition in the context of aging. We will specifically compare and contrast these relationships in HIV infected and uninfected men in order to address a series of linked hypotheses concerning possible mechanisms that may result in an apparent increase in the rate of cognitive dysfunction among HIV-infected individuals relative to age-matched controls.

描述（由申请人提供）：与艾滋病毒相关的认知功能障碍的患病率仍然很高，并且非艾滋病毒相关因素现在是认知障碍和大脑结构改变的重要风险调节因素，这可能是与患有艾滋病的美国人的健康相关的最重要因素。 HIV 疾病导致衰老。除了 50 岁以上个体出现的“正常”合并症外，感染（及其后果）似乎会改变几乎所有器官系统的正常年龄轨迹。可能会给大脑带来很大的负担，从而导致认知和行为的改变。令人担忧的是，许多目前患有艾滋病毒的 50 岁以上的人在 20 世纪 80/90 年代被感染，并经历了多年不受控制或控制不良的病毒复制。在这个五年更新期间 (AG034852)，我们将扩大这一范围。我们目前的样本为 400 名男性，另外还有 70 名 60 岁以上的男性，他们将每隔两年接受两次扫描/测试，最终形成 350 名男性样本，其中至少有两次扫描/测试。大脑成像方法将在 13 年内对多达 280 名男性进行 4 次扫描，评估大脑灰质和白质的完整性以及大脑功能网络的完整性、脑束描记、代谢物、脑血流和大脑的完整性。血我们将结合 15-30 年的先前信息来利用这些数据。从多中心艾滋病队列研究中，我们将完成对亚临床血管疾病、炎症、我们将专门比较和对比艾滋病毒感染者和未感染者的大脑结构和认知，以解决一系列有关可能导致认知功能障碍发生率明显增加的机制的相关假设。 HIV 感染者相对于年龄匹配的对照者。