Morphometric Analysis of the Superior Temporal Gyrus

颞上回的形态测量分析

• 批准号: 7160478
• 负责人: JOHN TILAK RATNANATHER
• 金额: $ 27.85万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7160478
• 关键词: Adopted; Anatomic structures; Anatomy; Area; Autistic Disorder; Bayesian Method; Bipolar Disorder; Brain; Brain Pathology; Cerebrospinal Fluid; Characteristics; Collaborations; Complex; Comprehension; Computer software; Computers; Development; Differential Diagnosis; Disease; Dyslexia; Economics; Etiology; Face; Functional disorder; Gender; Generations; Goals; Gold; Grant; Gray unit of radiation dose; Hand; Handedness; Hearing; Hybrids; Image; Individual; Knowledge; Language; Learning; Length; Localized; Location; MRI Scans; Manuals; Maps; Measurement; Measures; Mental disorders; Methodology; Methods; Metric; Parietal; Patients; Pattern; Physiology; Population; Prevalence; Principal Investigator; Process; Psyche structure; Purpose; Research; Research Personnel; Schizophrenia; Semantics; Shapes; Side; Standards of Weights and Measures; Structure; Superior temporal gyrus; Surface; Symptoms; Training; Uncertainty; Validation; Work; comparison group; cost; fly; gray matter; interest; memory recognition; phonology; programs; psychologic; shape analysis; vector; white matter

The superior temporal gyrus (STG) is important for hearing, language comprehension, learning, memory, recognition and semantic and phonological processing. Deficits of STG function are associated with pathological states (e.g., dyslexia, autism, schizophrenia). A quantitative characterization of the detailed anatomic structure of the STG is likely to be important in understanding both the normal function and pathological states related to its function as well as elucidate the differences between pathological groups. To conduct a thorough quantitative assessment of the STG, it is important to have a method capable of characterizing different parts of the STG reliably as well as analyzing shape and pattern characteristics. We propose the development and validation of such a method. Using conventional methods, we have already developed a highly reliable morphometric methodology to measure the STG and planum temporale (PT). Using that as a "gold standard," we propose to develop and validate semi-automated methods to measure these regions from a large population. Further, we will develop a shape analysis methodology to analyze the regions of the STG. Our lab currently has SGPR MRI scans on 30 schizophrenia patients individually matched with 30 normal subjects and 30 bipolar patients. We will use the above methods to investigate STG abnormalities in schizophrenia, This subject group provides an ideal starting point to validate semi-automated methods since schizophrenia patients have show STG cortical anomalies (e.g., reversed asymmetry of the PT) in morphometric studies. We believe the 30 bipolar patients are an important comparison group to the schizophrenia patients because it represents a psychiatric disorder that may have psychotic symptoms yet one in which there is no evidence of STG dysfunction. Defining differences in shape at specific locations of the STG and differences in gyral characteristics between patient groups and normal subjects may give important information about the etiology of schizophrenia, and aid in the differential diagnosis between schizophrenia and bipolar disorder.

上级颞回（STG）对于听力，语言理解，学习， 记忆，识别，语义和语音处理。 STG功能的缺陷为 与病理状态有关（例如阅读障碍，自闭症，精神分裂症）。定量 STG的详细解剖结构的表征很重要 了解正常功能和病理状态与其功能以及 阐明病理群体之间的差异。 为了对STG进行彻底的定量评估，重要的是要有一种能够可靠地表征STG的不同部分以及分析形状和模式特征的方法。我们提出了这种方法的开发和验证。使用常规方法，我们已经开发了一种高度可靠的形态学方法来测量STG和Planum terumale（PT）。我们建议将其作为“黄金标准”，我们建议开发和验证半自动化的方法，以测量大量人群中的这些区域。此外，我们将开发一种形状分析方法来分析STG的区域。 我们的实验室目前对30名精神分裂症患者进行了SGPR MRI扫描，该患者与30名正常受试者和30名双极患者单独匹配。我们将使用上述方法研究精神分裂症的STG异常，该学科组提供了验证半自动化方法的理想起点，因为精神分裂症患者在形态学研究中表明了STG皮质异常（例如，PT的反向不对称）。我们认为，与精神分裂症患者相比，30名双极患者是一个重要的比较组，因为它代表了一种可能患有精神病性症状的精神疾病，但没有STG功能障碍的证据。定义STG特定位置的形状差异以及患者群体和正常受试者之间的陀螺特性差异可能会提供有关精神分裂症病因的重要信息，并有助于精神分裂症和双相情感障碍之间的差异诊断。