Comprehensive Digital Atlas of the Macaque Brain

猕猴大脑综合数字图谱

• 批准号: 7269422
• 负责人: Douglas M. BOWDEN
• 金额: $ 52.09万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7269422
• 关键词: 3-Dimensional; Advisory Committees; Area; Atlases; Autistic Disorder; Base of the Brain; Brain; Brain imaging; Cell Nucleus; Communication; Communities; Complement component C1s; Data; Disease; Effectiveness; Face; Figs - dietary; Functional Magnetic Resonance Imaging; Gene Expression; Genes; Genetic; Genomics; Histologic; Human; Image; Imaging technology; Individual; Informatics; Institution; Internet; Lesion; Literature; Location; Macaca; Macaca mulatta; Magnetic Resonance Imaging; Maps; Mental disorders; Microscopic; Modeling; Neuroanatomy; Neurons; Nomenclature; Pattern; Play; Positioning Attribute; Positron-Emission Tomography; Primates; Relative (related person); Research; Research Personnel; Research Project Grants; Resolution; Resources; Role; Sampling; Scanning; Schizophrenia; Scientist; Screening procedure; Site; Slice; Source; Specific qualifier value; Specimen; Standards of Weights and Measures; Stereotaxis; Structure; Structure-Activity Relationship; Surface; System; Techniques; Testing; Universities; Variant; Washington; base; cell type; digital; improved; indexing; information display; lexical; nonhuman primate; prototype; psychologic; repository; response; three-dimensional modeling; tool

DESCRIPTION (provided by applicant): This project will enable researchers to map data from studies of the macaque brain over the Web into a fully segmented, high-resolution, spatially indexed, 3-dimensional brain atlas built on basic informatics and neuroanatomic principles. Investigators will be able to visualize and quantify the overlap between areas in which specific genes are expressed, areas of activation revealed by brain imaging (functional MRI or PET scan), classical brain structures and other experimental data, such as, areas containing particular kinds of nerve cells, and areas with connections to certain other brain structures. Noninvasive imaging technologies now allow scientists to scan the whole brain for focal areas of activity associated with specific psychological phenomena. Similarly, modern genomics allows rapid screening of the whole brain for focal areas of gene expression. Such techniques hold great promise for analyzing structure-function relationships in the brain, but they do not reveal the anatomical boundaries of cortical areas well enough for researchers to precisely identify the anatomical locations of activation or genetic involvement. This project will allow researchers to generate template cross-sections of the brain at any angle and position from a 3D digital atlas, modify them to match individual variation, and overlay them on experimental histologic, MRI or PET sections to show the approximate boundaries of structures not visible by those techniques. The informatics component of the project will merge landmark boundaries identified by MRI, block face photos and histological photomicrographs to produce a digital 3-dimensional template atlas of the entire rhesus (Macaca mulatta) brain. The 3D model will reside in the BrainInfo website at the National Primate Research Center at the University of Washington. Researchers at other institutions will be able to map a variety of kinds of data into the atlas over the Web for comparison with data mapped by others. The maps, as well as many other kinds of brain information, will thus be shared with the entire neuroscientific community. 2) The research component of the project will be to map in the nonhuman primate brain the expression of genes that have been implicated in certain human psychiatric disorders. This project will accelerate the communication of new research findings among neuroscientists the world over and will improve our understanding of areas of the brain involved in such disorders as autism and schizophrenia.

描述（由申请人提供）：该项目将使研究人员能够将网络猕猴大脑的研究映射到完全分割的，高分辨率的，空间索引的，三维的大脑图片上，建立在基本的信息和神经解剖学原理上。研究人员将能够可视化和量化表达特定基因的区域之间的重叠，通过脑成像揭示的激活区域（功能性MRI或PET扫描），经典的大脑结构和其他实验数据，例如包含特定类型的区域神经细胞和与某些其他大脑结构有连接的区域。现在，无创成像技术使科学家可以扫描整个大脑，以了解与特定心理现象相关的活动领域。同样，现代基因组学允许快速筛选整个大脑，以了解基因表达的焦点区域。这种技术在分析大脑中的结构功能关系方面具有巨大的希望，但是它们并没有很好地揭示皮质区域的解剖界限，足以使研究人员精确地识别激活或遗传参与的解剖位置。该项目将使研究人员能够从3D数字地图集以任何角度和位置生成大脑的模板横截面，修改它们以匹配个体变异，并在实验性组织学，MRI或PET段上叠加它们，以显示结构的近似边界这些技术看不见。该项目的信息学部分将合并MRI确定的地标边界，块面照片和组织学显微照片，以产生整个恒河类（Macaca Mulatta）大脑的数字3维模板地图集。 3D模型将居住在华盛顿大学国家灵长类动物研究中心的Braininfo网站上。其他机构的研究人员将能够通过网络将各种数据映射到地图集中，以将其与其他人映射的数据进行比较。因此，地图以及许多其他类型的大脑信息将与整个神经科学社区共享。 2）该项目的研究组成部分将是在非人类灵长类动物大脑中绘制与某些人类精神疾病有关的基因的表达。该项目将加速世界各地神经科学家之间的新研究结果的交流，并将提高我们对涉及自闭症和精神分裂症等疾病的大脑领域的理解。