High efficiency particulate air cleaner intervention to reduce respiratory virus exposure in elementary schools

高效颗粒空气净化器干预减少小学呼吸道病毒暴露

基本信息

批准号：
10722583
负责人：
Peggy Sue Lai
金额：
$ 27.49万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-10 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10722583
关键词：
Adenoviruses Adherence Air Allergens Asthma Behavior COVID-19 outbreak COVID-19 pandemic COVID-19 patient Child Coronavirus Data Detection Disinfectants Dose Enterovirus Environment Exposure to Fatigue Future Goals Handwashing Home Household Human Humidity Individual Indoor environment Infection Infection Control Influenza A virus Infrastructure Intention Intervention Intervention Studies Intervention Trial Masks Measles Metapneumovirus Mission Molecular Morbillivirus Mumps virus Nature Nose Parainfluenza Particulate Placebo Control Predictive Factor Public Health Publishing Randomized Randomized, Controlled Trials Research Respiratory syncytial virus Rhinovirus Risk Rubella virus SARS coronavirus Sampling Schools Source Students Study models Surface Surveys Symptoms Temperature Testing United States National Institutes of Health Vaccines Viral Viral Load result Viral Respiratory Tract Infection Virus Virus Diseases air sampling asthma exacerbation asthmatic built environment cohort digital disease transmission efficacy evaluation efficacy testing elementary school environmental intervention evidence base high efficiency particulate air filter influenzavirus inner city innovation meter pandemic disease pandemic influenza portability post-COVID-19 protective behavior public health intervention randomized placebo controlled trial randomized trial recruit respiratory infection virus respiratory virus school environment school reopening screening secondary analysis transmission process ventilation viral detection

项目摘要

PROJECT SUMMARY/ABSTRACT There is a fundamental gap in understanding the extent to which the school environment contributes to respiratory virus exposure, and less is known about effective environmental interventions to reduce exposure. Our long-term goal is to create healthy indoor school environments for children. The overall objective of this application is to identify environmental predictors of and potential interventions influencing respiratory virus exposure in elementary schools. We will extend the robust infrastructure of the School Inner-City Asthma Intervention Study (SICAS-2, ClinicalTrials.gov NCT02291302), a five-year randomized controlled trial conducted by our group of a placebo-controlled classroom high efficiency particulate air (HEPA) cleaner intervention to continue cohort recruitment in the post-COVID-19 pandemic period. We will test our central hypothesis that modifiable built environment factors influence airborne respiratory virus exposure and infection in elementary schools through the following specific aims: (1) To determine the efficacy of a randomized placebo controlled HEPA cleaner intervention in reducing classroom airborne respiratory virus exposure; (2) To determine the efficacy of a randomized placebo controlled HEPA cleaner intervention in reducing symptomatic and asymptomatic respiratory viral infections in asthmatic children. The approach is innovative, because we are simultaneously interrogating all major human respiratory viruses in the context of a school-based randomized trial focused on an environmental intervention. The proposed research is significant, because if the HEPA intervention can reduce respiratory virus exposure and infections in schools, it is an immediately actionable and practical intervention to create safer indoor environments for elementary school children. Results from this proposal may be generalizable to other public indoor settings.

项目摘要/摘要理解学校环境贡献的程度有根本的差距呼吸道病毒暴露，对有效的环境干预以减少暴露量的了解少。我们的长期目标是为儿童创造健康的室内学校环境。总体目标应用是确定影响呼吸道病毒的环境预测因素和潜在干预措施小学的接触。我们将扩展学校内城哮喘的强大基础设施干预研究（SICAS-2，ClinicalTrials.gov NCT02291302），一项为期五年的随机对照试验由我们组的安慰剂控制的教室高效颗粒空气（HEPA）清洁剂进行干预措施在199年后的大流行时期继续招募队列。我们将测试我们的中央假设可修改的建筑环境因素会影响空中呼吸道病毒和感染在小学通过以下特定目的：（1）确定随机的功效安慰剂控制的HEPA清洁剂干预措施减少教室空气呼吸道病毒的暴露；（2）至确定随机安慰剂控制的HEPA清洁剂干预措施减少症状的功效哮喘儿童中无症状的呼吸道病毒感染。这种方法是创新的，因为我们在基于学校的背景下，同时询问所有主要的人类呼吸道病毒随机试验的重点是环境干预。拟议的研究很重要，因为如果 HEPA干预可以减少学校的呼吸道病毒的暴露和感染，这是一个立即可操作且实用的干预措施，为小学生创造更安全的室内环境。该提案的结果可能可以推广到其他公共室内环境。