NHP Core

NHP核心

• 批准号: 10724223
• 负责人: Dan H. Barouch
• 金额: $ 28.54万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-11 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724223
• 关键词: Animal Model; Animals; Blood specimen; Cataloging; Clinical; Complex; Data Analyses; Data Collection; Ensure; Goals; HIV-1; Human Resources; Infection; Infrastructure; Israel; Laboratories; Leadership; Logistics; Macaca mulatta; Medical center; Positioning Attribute; Procedures; Program Research Project Grants; Protocols documentation; Quality Control; Reagent; Research; SIV; Sampling; Technical Expertise; Tissue Sample; Vaccine Therapy; animal care; experience; in vivo; multiple omics; neutralizing antibody; nonhuman primate; programs; simian human immunodeficiency virus; vaccine trial

SUMMARY Infection of rhesus macaques with simian immunodeficiency virus (SIV) or simian-human immunodeficiency virus (SHIV) is a key animal model for HIV-1 infection. Nonhuman primates (NHP) are complex, higher order species that require specialized infrastructure and experienced staff in a research setting. Core D (NHP Core) aims to support this P01 program by providing all the expertise, infrastructure, reagents, personnel, animals, and logistics for the conduct of complex in vivo studies in rhesus macaques. Core D will involve leadership from Beth Israel Deaconess Medical Center and Bioqual and is well positioned to meet program objectives. The goal of Core D is to provide leadership and technical expertise to ensure consistency and quality control in animal selection, execution of study protocols, experimental procedures, sample acquisition and distribution, and data collection and analysis. To accomplish this goal, we propose three Specific Aims: Aim 1. To support this P01 program by selecting and providing rhesus macaques, providing exceptional animal care, and conducting experimental vaccine studies Aim 2. To provide facilities for the receipt, cataloging, processing, storage, and distribution of blood and tissue samples in compliance with Good Clinical Laboratory Practice Aim 3. To obtain and to maintain all required regulatory approvals for the proposed studies

概括 用猿猴免疫缺陷病毒（SIV）或猿猴 - 人类免疫缺陷病毒感染猕猴 （SHIV）是HIV-1感染的关键动物模型。非人类灵长类动物（NHP）是复杂的，高阶的物种 在研究环境中，需要专门的基础设施和经验丰富的员工。核心D（NHP核心）的目标 通过提供所有专业知识，基础设施，试剂，人员，动物， 和物流，用于进行恒河猕猴中的复杂体内研究。核心D将涉及领导 从贝丝以色列执事医疗中心和生物试验中心，并且在实现计划目标方面有好处。这 核心D的目标是提供领导和技术专长，以确保一致性和质量控制 动物的选择，研究方案的执行，实验程序，样本采集和分布以及 数据收集和分析。为了实现这一目标，我们提出了三个具体目标： 目标1。通过选择和提供恒河猕猴来支持此P01程序，提供出色的动物 护理和进行实验疫苗研究 目标2。为血液和组织的接收，分类，加工，存储和分布提供设施 样本符合良好的临床实验室实践 目的3。要获得并维持所有必需的监管批准