Geospatial food access as a driver of environmental oxidant stressors and early obesity

地理空间食物获取是环境氧化应激和早期肥胖的驱动因素

基本信息

批准号：
10723545
负责人：
Carol Duh-Leong
金额：
$ 26.16万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-17 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10723545
关键词：
Address Age American Heart Association Anxiety Asian Automobile Driving Biological Markers Biology Birth Birth Weight Black race Cardiovascular system Chemical Exposure Chemicals Child Child Health Clinical Data Data Set Development Dietary Practices Disparity Educational process of instructing Endocrine disruption Environment Environmental Epidemiology Environmental Exposure Ethnic Origin Ethnic Population Exposure to Fatty acid glycerol esters Food Food Access Food Packaging Food Supply Goals Guidelines Health Food Healthy Eating Hispanic Home Household Human Individual Intake Interruption Investments Joints Knowledge Life Life Cycle Stages Literature Measures Mentors Mentorship Metabolic Methodology Minority Groups Modeling Molecular Weight National Health and Nutrition Examination Survey National Institute of Environmental Health Sciences Neighborhoods Obesity Outcome Oxidants Oxidative Stress Parents Participant Pathway interactions Persons Physiological Positioning Attribute Pregnancy Preparation Process Psychosocial Stress Public Health Race Research Research Personnel Resources Restaurants Risk Role Savory Site Skinfold Thickness Statistical Methods Stress Structure Supermarket Time Training United States National Institutes of Health Weight Work built environment cardiometabolism cardiovascular risk factor career development cohort craving data integration dietary excess early childhood ethnic disparity fast food food environment food insecurity gestational weight gain in utero indexing infancy longitudinal analysis medical schools mother nutrition obesity in children obesity risk patient oriented research phthalates postnatal pregnant prenatal programs psychosocial psychosocial stressors public health insurance racial disparity racial population rapid infant weight gain rapid weight gain skills social social influence socioeconomic disparity socioeconomics stressor urinary

项目摘要

PROJECT SUMMARY/ABSTRACT Racial/ethnic and socioeconomic disparities in obesity begin early in life. Excessive caloric imbalance in pregnancy is a leading suspected contributor to early weight disparities. Yet, prior studies have not accounted for how limited food access may also drive chemical and psychosocial exposures that influence developmental cardiovascular and metabolic programming to increase early childhood obesity risk. This Mentored Patient- Oriented Research Career Development K23 proposal investigates how geospatial food access and environmental oxidant stressors contribute to childhood obesity, a serious public health challenge and priority of the National Institute of Environmental Health Sciences. Simultaneously, it will prepare the candidate, Carol Duh-Leong, MD, MPP, to become an independent investigator who will address neighborhood disparities that influence the social and chemical context of early child obesity. This study leverages longitudinal data from the NYU Children’s Health and Environment Study, a participating birth cohort (50% Hispanic, 8% Asian, 7% Black; 57% Public Insurance) in the NIH ECHO program that follows pregnant people prenatally and their children postnatally through early childhood. The candidate proposes to geocode participant home addresses and food environment data to longitudinally model joint relationships among geospatial food access, environmental oxidant stressors, and early childhood obesity outcomes. Specific aims are: 1) Examine whether limited geospatial food access increases phthalate and bisphenol exposures in pregnancy; 2) Examine relationships between limited geospatial food access, psychosocial stressors, and oxidative stress in pregnancy; and 3) Evaluate joint effects of geospatial food access and environmental oxidant stressors across pregnancy and infancy on early childhood obesity outcomes. Closing this gap in knowledge would inform built environment investments and neighborhood strategies to interrupt environmental oxidant stressors and decrease obesity risk through the life course. Through the execution of these aims, the candidate will pursue the following mentored training goals: 1) Advanced geospatial analysis; 2) Environmental exposure and biomarker assessment; 3) Longitudinal analysis and environmental mixture modeling. This proposal draws upon world-class clinical, research, and teaching resources available at NYU Grossman School of Medicine for the candidate’s research and training aims. The candidate has assembled an expert mentorship team of content experts in environmental epidemiology, geospatial analysis, exposure and biomarker assessment, and advanced statistical methods to guide her research and training. This team will provide on-site training tailored to the proposed research aims and will guide the candidate’s transition to independence and her establishment of a research program that applies an interdisciplinary life course approach towards understanding the social and environmental context of early child obesity.

项目概要/摘要肥胖的种族/民族和社会经济差异在生命早期就开始出现。怀孕可能是导致早期体重差异的一个主要因素，但之前的研究尚未考虑到这一因素。了解有限的食物获取可能如何导致影响发育的化学物质和社会心理暴露心血管和代谢规划可增加儿童早期肥胖风险。面向研究职业发展 K23 提案调查了地理空间食物获取和环境氧化应激导致儿童肥胖，这是一个严重的公共卫生挑战和优先事项同时，它还将准备候选人卡罗尔。 Duh-Leong，医学博士，MPP，成为一名独立调查员，将解决社区差异问题影响早期儿童肥胖的社会和化学背景这项研究利用了来自儿童肥胖的纵向数据。纽约大学儿童健康与环境研究，参与出生队列（50% 西班牙裔、8% 亚裔、7% 黑人；57% 公共保险）在 NIH ECHO 计划中，该计划跟踪孕妇及其产前情况候选人建议对参与者的家庭地址进行地理编码。和食品环境数据，以纵向模拟地理空间食品获取之间的联合关系，具体目标是：1) 检查是否存在环境氧化应激因素和儿童早期肥胖结果。有限的地理空间食物获取会增加妊娠期邻苯二甲酸盐和双酚的暴露；2) 检查有限的地理空间食物获取、社会压力源和氧化应激之间的关系怀孕；3) 评估地理空间食物获取和环境氧化剂压力因素的联合影响怀孕和婴儿期对儿童早期肥胖结果的影响将缩小这一知识差距。环境投资和邻里战略，以中断环境氧化剂压力源和通过实现这些目标，候选人将追求在整个生命过程中降低肥胖风险。以下指导培训目标： 1) 高级地理空间分析 2) 环境暴露和生物标志物评估；3）纵向分析和环境混合物建模。纽约大学格罗斯曼医学院提供世界一流的临床、研究和教学资源候选人的研究和培训目标候选人组建了一个专家指导团队。环境流行病学、地理空间分析、暴露和生物标志物评估方面的内容专家，以及先进的统计方法来指导她的研究和培训。该团队将提供量身定制的现场培训。达到拟议的研究目标，并将指导候选人向独立过渡和建立应用跨学科生命历程方法来了解社会的研究计划以及早期儿童肥胖的环境背景。