Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center

胰腺炎研究联盟：匹兹堡临床中心

• 批准号: 9352325
• 负责人: DAVID Clement WHITCOMB
• 金额: $ 40.82万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9352325
• 关键词: Accelerometer; Adoption; Adult; Affect; Area; Bioinformatics; Biological; Biological Markers; Biometry; Caring; Case Report Form; Cellular biology; Child; Childhood; Clinic; Clinical; Clinical Cancer Center; Clinical Research; Collaborations; Communication; Communities; Complex; Complications of Diabetes Mellitus; Consensus; DNA; Data; Data Analyses; Development; Diabetes Mellitus; Disease; Disease Management; Disease Progression; Disease model; Duct (organ) structure; Early Diagnosis; Effectiveness; Electronic Health Record; Ensure; Environmental Risk Factor; Epidemiology; Etiology; Evolution; Exclusion Criteria; Faculty; Failure; Fibrosis; Functional disorder; Future; Genetic; Genetic Risk; Germ; Goals; Hereditary Disease; Image; Inflammation; Knowledge; Leadership; Longitudinal cohort study; Malignant neoplasm of pancreas; Measures; Medical; Methods; Modeling; Monitor; Multicenter Studies; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Pain; Pancreas; Pancreatic Diseases; Pancreatic Ductal Adenocarcinoma; Pancreatic enzyme; Pancreatitis; Participant; Pathogenesis; Pathogenicity; Pathologic; Pathway interactions; Patients; Periodicity; Phenotype; Physicians; Physiology; Process; Recording of previous events; Recruitment Activity; Recurrence; Registries; Research; Research Subjects; Resources; Risk; Risk Assessment; Risk Factors; Sampling; Specimen; Standardization; Syndrome; Testing; Therapeutic; Time; Universities; Virulence Factors; Work; acute pancreatitis; alcoholic chronic pancreatitis; authority; base; biobank; chronic pancreatitis; clinical biomarkers; clinical infrastructure; cohort; cost; cost effective; data management; design; diabetes risk; disorder prevention; disorder subtype; experience; faculty research; follow-up; gene environment interaction; illness length; improved; individual patient; innovation; male; member; multidisciplinary; new technology; patient oriented; patient registry; personalized medicine; predictive modeling; programs; public health relevance; research study; success; theories; therapeutic target

 DESCRIPTION (provided by applicant): Pittsburgh Clinical Center (PCC) is a clinical-translational program at the University of Pittsburgh and UPMC designed to conduct studies on recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and factors that increase the risk of fibrosis, pain, and pancreatogenic diabetes (T3cDM) in children and adults, and risk of pancreatic ductal adenocarcinoma (PDAC) in adults with CP and/or DM. Multi-disciplinary teams at the University of Pittsburgh and UPMC are organized to participate in comprehensive clinical, epidemiological and biological characterization of patients with pancreatic disorders and to define the pathophysiology of RAP & CP and their sequela. Three specific aims are proposed: Aim 1. To develop integrated clinical center core processes to facilitate data and biosample management, to maximize communication and to evaluate of new technologies. Aim 2. To establish a model longitudinal research cohort of patients during evolution of definite CP. Aim 3. To generate and test a framework to analyze risk factors affecting the progression of RAP, probable CP and definite CP, and clinically useful biomarkers to monitor disease state and endpoints. Our existing and well-established, efficient and effective clinical infrastructure for patient accrual, sample processing, disease progression assessment, data management and analysis will support the program. The rich clinical volume, expert physician phenotypers in all critical areas, established leadership in epidemiology, genetics, physiology, cell biology, imaging, biostatistics and bioinformatics, and all relevant disease subtypes, plus administrative authority in clinical and research areas for both the adult and children ensure continued success. The history of strong collaborations and working relationships of the PCC faculty with many outstanding programs at other universities will also provide momentum to the national consortium.

 描述（由申请人提供）：匹兹堡临床中心 (PCC) 是匹兹堡大学和 UPMC 的一个临床转化项目，旨在对复发性急性胰腺炎 (RAP) 和慢性胰腺炎 (CP) 以及增加复发风险的因素进行研究儿童和成人的纤维化、疼痛和胰源性糖尿病 (T3cDM)，以及成人 CP 和/或胰腺导管腺癌 (PDAC) 的风险匹兹堡大学和 UPMC 组织多学科团队参与胰腺疾病和糖尿病患者的全面临床、流行病学和生物学特征研究。 提出了三个具体目标： 目标 1. 开发综合临床中心核心流程，以促进数据和生物样本管理，最大限度地进行沟通并评估新技术。明确 CP 演变过程中患者的模型纵向研究队列 目标 3. 生成并测试一个框架来分析影响 RAP、可能 CP 和明确 CP 进展的风险因素，以及用于监测疾病状态和临床有用的生物标志物。我们现有的、完善的、高效且有效的临床基础设施，用于患者应计、样本处理、疾病进展评估、数据管理和分析，将支持该计划丰富的临床量、所有关键领域的专家医师表型，并在该领域建立领导地位。流行病学、遗传学、生理学、细胞生物学、成像、生物统计学和生物信息学以及所有相关疾病亚型，加上成人和儿童临床和研究领域的管理权威，确保了持续成功的强大合作和工作关系。 PCC 教师在其他大学拥有许多出色的项目，也将为国家联盟提供动力。