Core Grant for Vision Research - Core 3

视觉研究核心资助 - 核心 3

• 批准号: 10715684
• 负责人: Colleen Mary McDowell
• 金额: $ 11.93万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10715684
• 关键词: Anesthesia procedures; Animal Experimentation; Animal Model; Animals; Communicable Diseases; Core Grant; Data; Disease; Equipment; Evaluation; Experimental Models; Eye; Eye diseases; Funding; Glaucoma; Goals; Mission; Modeling; Organ Culture Techniques; Pathway interactions; Pattern; Pharmacology and Toxicology; Qualifying; Research Personnel; Retinal Degeneration; Rodent; Structure; United States National Institutes of Health; Vascular Diseases; Vision; Vision research; Visual; Visual System; inter-institutional; nonhuman primate; retinal imaging; tonometry; translational pipeline

CORE 3: ANIMAL MODELS AND EYE ORGAN CULTURE ABSTRACT The goal of the Animal Models and Eye Organ Culture Core is to facilitate the use of animals and eye organ culture to study visual function and visual diseases by qualifying NEI funded researchers. We also assist non- qualifying investigators in generating preliminary data, in support of proposals seeking NIH funding. This is accomplished by providing expertise in complementary animal models across a range of species from rodents to non-human primates (NHPs) and including spontaneous and experimental models of glaucoma, retinal degeneration, ocular vascular disease ocular pharmacology and toxicology and infectious diseases and includes animal handling and anesthesia and, importantly, provision of alternatives to live animal research including eye organ culture. We provide expertise and equipment necessary for the evaluation of visual system structure and function including ERG, multifocal and pattern ERG, VEP, OCT, retinal imaging, tonometry and outflow facility and outflow pathway determination. As a result of unique expertise and access to model species spanning the translational spectrum, this core has had a broad impact, facilitating interdisciplinary and inter-institutional vision research in support of the NEI’s mission.

核心 3：动物模型和眼器官培养 抽象的 动物模型和眼器官培养核心的目标是促进动物和眼器官的使用 我们还协助非 NEI 资助的研究人员研究视觉功能和视觉疾病。 合格的研究人员生成初步数据，以支持寻求 NIH 资助的提案。 通过提供一系列啮齿动物的补充动物模型方面的专业知识来完成 非人类灵长类动物 (NHP)，包括青光眼、视网膜、自发性和实验性模型 变性、眼血管疾病、眼药理学和毒理学以及感染性疾病和 包括动物处理和麻醉，重要的是，提供活体动物研究的替代方案 我们提供视觉评估所需的专业知识和设备。 系统结构和功能，包括 ERG、多焦点和模式 ERG、VEP、OCT、视网膜成像、 眼压测量和流出设施以及流出测定途径。 作为跨越转化谱的模型物种，这一核心产生了广泛的影响，促进 支持 NEI 使命的跨学科和跨机构愿景研究。