UNC Research Training Program in Respiratory Diseases and Critical Care

北卡罗来纳大学呼吸系统疾病和重症监护研究培训计划

• 批准号: 10714527
• 负责人: Richard Charles Boucher
• 金额: $ 52.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714527
• 关键词: Critical Care; Research Training; Respiratory Disease; Training Programs

Project Summary/Abstract This proposal for a new T32 Program titled “UNC Research Training Program in Respiratory Diseases and Critical Care” at The University of North Carolina-Chapel Hill supports 6 postdoctoral trainees with M.D., M.D./Ph.D. or Ph.D. degrees for research training in lung disease, emphasizing a joint training program for Medicine and Pediatric trainees. The Program provides multidisciplinary training in basic, translation and clinical research within the pulmonary and critical care divisions of the Departments of Medicine and Pediatrics and our three Research Centers devoted to understanding lung health and disease. Our Program offers a Training Faculty of 48 trainers (38 mentors, 8 junior mentors and 2 co-mentors) from 7 clinical (2) and basic science (5) departments in the School of Medicine. M.D. trainees will enter at years 3-5 in their clinical and research training, designed to provide them with skills required for a leadership career in academic pulmonary medicine. Ph.D. trainees will typically enter in the second year of their post-doctoral fellowship, and they will be well integrated into the basic, translational and clinical aspects of their project. Each trainee will have a scholarly oversight committee that includes mentors from varying disciplines who will facilitate their scientific growth and career development, including grant writing and leadership skills. Each trainee will be welcomed into a DEI culture, will take workshops, and will become embedded in this culture. Each area of lung research is multidisciplinary in nature and emphasizes a broader knowledge of the basic, translational, clinical and impact implications for each trainee's question. Areas of research include cystic fibrosis, primary ciliary dyskinesia, idiopathic bronchiectasis, cell and molecular biology of airway epithelia in health and disease, leukocyte kinetics and clinical research in COPD, control of airway inflammation, inflammatory and innate immune responses during ARDS and bacterial and viral infections, clinical trials, comparative effectiveness research, analyses of qualitative narrative data, and large cohort studies in critical care, basic and translational proteomics of airways and alveoli, the airway microbiome in health and disease, the responses to injury by physical, chemical, and microbial environmental agents, and clinical and basic science studies in asthma. Novel programs that exemplify the multi-disciplinary nature include ARDS and Critical Care Research, the CF Research Program, and Combustion-induced Bronchitis in the Military, each of which require cross-disciplinary interactions amongst a wide range of expertise to accomplish their goals. Clinical studies will be integrated with basic observations using translational physiologic, biochemical, molecular and genetic technologies, and -omics approaches and will provide training in state-of-the-art –omics and other basic technologies, bioinformatics, database design, use and analyses, and statistical interpretation. Emphasis is on mechanisms underlying lung diseases in pediatric and adult populations and development of novel therapeutic strategies. Our Program provides an opportunity for trainees to develop as scientists and become independent investigators and leaders within the national community.

项目摘要/摘要 这项针对新的T32计划的提案，名为“ UNC研究呼吸道疾病研究培训计划和 北卡罗来纳大学 - 教堂山的重症监护”为6名博士后学员提供医学博士学位。 M.D./PH.D。或博士学位肺部疾病研究培训的学位，强调了联合培训计划 医学和小儿学员。该计划提供基本，翻译和临床的多学科培训 医学和儿科部门的肺部和重症监护部门的研究 三个研究中心致力于了解肺部健康和疾病。我们的计划提供培训 来自7个临床（2）和基础科学（5）的48位培训师的教职 医学院的系。医学博士学员将以3 - 5年的临床和研究培训进入 旨在为他们提供学术肺医学领导职业所需的技能。博士 学员通常会在博士后奖学金的第二年进入 进入其项目的基本，翻译和临床方面。每个实习生都会有一个科学的监督 包括不同学科的导师，这些委员会将促进其科学成长和职业 发展，包括赠款写作和领导能力。每个学员都将受到Dei文化的欢迎，将 参加研讨会，并将嵌入这种文化中。肺部研究的每个领域都是多学科的 自然，并强调对每种基本，翻译，临床和影响影响的更广泛的了解 实习生的问题。研究领域包括囊性纤维化，原发性睫状运动障碍，特发性支气管扩张， 健康和疾病，白细胞动力学和临床研究的气道上皮细胞和分子生物学 COPD，控制气道感染，ARD和细菌期间的炎症和先天免疫回报 和病毒感染，临床试验，比较有效性研究，定性叙事数据的分析以及 重症监护，基本和翻译的蛋白质组学和气道蛋白质组学的大型队列研究，气道 健康和疾病中的微生物组，物理，化学和微生物环境对损伤的反应 哮喘的代理商以及临床和基础科学研究。示例多学科的新颖节目 大自然包括ARDS和重症监护研究，CF研究计划以及燃烧引起的 军事中的支气管炎，每种都需要广泛的专业知识之间的跨学科互动 实现他们的目标。临床研究将与使用翻译的基本观察结果整合 物理，生化，分子和遗传技术以及-omics方法，将提供训练 在最先进的 - 组和其他基本技术中，生物信息学，数据库设计，使用和分析以及 统计解释。重点是小儿和成人种群中肺部疾病的机制 以及新型治疗策略的制定。我们的计划为受训者提供了一个机会 作为科学家并成为民族社区中的独立调查员和领导人。