THE CONTINUUM OF CARE IN HOSPITALIZED PATIENTS WITH OPIOID USE DISORDER AND INFECTIOUS COMPLICATIONS OF DRUG USE (CHOICE)

患有阿片类药物使用障碍和药物使用感染并发症的住院患者的连续护理（选择）

基本信息

批准号：
10717509
负责人：
MATTHEW KIRKBY
金额：
$ 233万
依托单位：
PPD DEVELOPMENT LP
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10717509
关键词：
Academic Medical Centers Address Aftercare Alabama Bacterial Infections Baltimore Caring Communicable Diseases Complication Consult Continuity of Patient Care District of Columbia Drug usage Effectiveness of Interventions Epidemic Goals HIV Healthcare Helping to End Addiction Long-term Hepatitis C virus Hospitalization Hospitals Individual Infection Infective endocarditis Inpatients Intervention Investigation Location Maryland Medicaid Medical Medical center Modeling Opiate Addiction Opioid Outcome Outpatients Patients Pharmaceutical Preparations Public Health Research Rural Population Speed System Time United States United States National Institutes of Health Universities University Hospitals Washington addiction high risk improved improved outcome multidisciplinary opioid epidemic opioid misuse opioid use disorder prevent uptake

项目摘要

In the United States, there is an opioid epidemic which is associated with acquisition of HIV, HCV and STIs, as well as rising rates of infective endocarditis and systemic bacterial infections.(1-3) Given the clear intersection of these parallel epidemics of infectious diseases and opioid use disorder, it is critical that we identify models of care which prevent acquisition of these infections and enhance treatment of existing infections by addressing opioid use disorder throughout the continuum of care.(4,5) Many individuals with opioid use disorder (OUD) are not engaged in medical care, therefore, inpatient hospitalization represents an opportune time to initiate treatment and engagement among these high risk individuals. However, inpatient interventions to address addiction are often suboptimal, incomplete, or limited to the time of hospitalization.(6) Further, observational investigations in individual hospital systems have demonstrated the effectiveness of interventions, including addiction consult teams, multidisciplinary rounds, and linkage navigators, in increasing uptake of medications for opioid use disorder during hospitalization and linkage into addictions treatment after discharge. However, there have been no multi-center investigations to rigorously evaluate the impact of these interventions on long term infectious outcomes. This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction

在美国，有一种阿片类药物流行，与收购HIV，HCV和ETI的获取以及感染性心内膜炎和全身细菌感染的速率上升有关。（1-3）鉴于这些平行的疾病和阿片类药物的疾病的依赖，这是在这些平行流行病上的明确相互作用，从而鉴定出对这些疾病的关键，这是在识别的，这是识别的，从而鉴定出这些模型，从而鉴定出这些模型，从而可以使这些模型的疾病及其疾病，从而确定这些模型，这些疾病的因素是至关重要的。（4,5）许多患有阿片类药物使用障碍（OUD）的人没有从事医疗服务，因此，住院住院治疗是在这些高风险个人中开始治疗和参与的机会。但是，要解决的住院治疗措施通常是最佳，不完整或仅限于住院时间。（6）此外，进一步的医院系统中的观察投资表明了干预措施的有效性，包括成瘾团队，多学科回合，多学科的回合和连杆导航剂，以增加对药物治疗的药物治疗，并在链接中增加了障碍和链接的治疗。但是，没有进行多中心研究来严格评估这些干预措施对长期传染性结果的影响。这项研究是NIH的一部分，有助于长期（HEL）倡议结束成瘾，以加快对国家阿片类药物公共卫生危机的科学解决方案。 NIH Heal Heal倡议Bolsters跨NIH的研究，以改善阿片类药物滥用和成瘾的治疗