Mystery of the Crooked Cell 2.0: CityLab's Next Generation SocioscientificApproach to Gene Editing

弯曲细胞之谜 2.0：CityLab 的下一代基因编辑社会科学方法

• 批准号: 10745382
• 负责人: DONALD A DEROSA
• 金额: $ 27.08万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-03 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745382
• 关键词: Mystery; Crooked; Cell; 2.0; CityLab

Project Summary/Abstract Boston University School of Medicine’s new SEPA project, entitled "Mystery of the Crooked Cell 2.0: CityLab’s Next Generation Socioscientific Approach to Gene Editing," addresses the imperative that NIH's pre-college activities focus on biomedical workforce preparedness, especially for underrepresented minorities (URM). This project will reach close to 600 local URM students and, through planned dissemination, will reach thousands of students. CityLab is partnering with five Boston-area high schools and two afterschool STEM/health professions enrichment programs to test the effectiveness of embedding a focus on socioscientific reasoning (SSR) to promote understanding of gene editing. An SSR approach places science content in a meaningful social context and motivates students to take ownership of their learning. SSR skills include realizing the complexity of the content and context of an issue, analyzing an issue from multiple perspectives, seeking out sources of bias in data, and considering how and whether scientific investigations can advance understanding of an issue. This project will expand CityLab’s “Mystery of the Crooked Cell” hands-on, inquiry-based curriculum supplement that focuses on the molecular basis of sickle cell disease (SCD) by incorporating state-of-the-art gene editing content that is suffused with SSR. The new curriculum supplement, Mystery of the Crooked Cell 2.0 (MCC 2.0), will seamlessly integrate three elements: CityLab’s curriculum storyline and laboratory experiences, computer simulations of molecular biology assays developed at University of Wisconsin-River Falls, and immersive virtual reality simulations of gene editing for SCD therapies developed at UC Berkeley Innovative Genomics Institute. SSR will be embedded throughout MCC 2.0, as will awareness of STEM/biomedical science careers. CityLab will also build NextGen Scholars, a learning community that will not only engage students in advanced science content and lab applications using SSR but also foster attitudes that support equity and diversity in STEM. This project will demonstrate the feasibility and replicability of this pedagogical strategy; CityLab will then disseminate the curriculum widely and thereby sow the seeds for a diverse and inclusive future STEM workforce. The major objectives of the proposed project are: (1) to create MCC 2.0 in collaboration with high school teachers and students, (2) to build a diverse community of learners who use SSR to explore advanced science topics while gaining insights into the importance of diversity, equity, inclusion, and social justice in science, health, and society, (3) to examine changes in students’ science content understanding, SSR skills, science learner identity, and attitudes towards diversity in the biomedical sciences and medicine, (4) to track student participants through college to understand the broader impact of this approach, and (5) to earn designation as one of the first “High- Quality Design” high school lessons that are aligned to the Next Generation Science Standards (NGSS). This new SEPA initiative is a unique way to pilot, refine, and disseminate a first-of-its-kind science education program that will increase the diversity of the STEM/biomedical science workforce.

项目概要/摘要 波士顿大学医学院的新 SEPA 项目，题为“弯曲细胞 2.0 之谜：CityLab 的 下一代基因编辑的社会科学方法，”解决了 NIH 大学预科课程的必要性 活动重点是生物医学劳动力的准备，特别是针对代表性不足的少数群体（URM）。 该项目将惠及近 600 名当地 URM 学生，并通过有计划的传播，惠及数千名学生 CityLab 正在与波士顿地区的五所高中和两个课外 STEM/健康专业合作。 强化计划，以测试将社会科学推理 (SSR) 纳入关注的有效性 促进对基因编辑的理解。SSR 方法将科学内容置于有意义的社会背景中。 并激励学生掌握 SSR 技能，包括认识到学习的复杂性。 问题的内容和背景，从多个角度分析问题，找出偏见的来源 数据，并考虑科学研究如何以及是否可以增进对问题的理解。 该项目将扩展 CityLab 的“弯曲细胞之谜”实践、探究式课程补充 通过结合最先进的基因编辑技术，重点研究镰状细胞病 (SCD) 的分子基础 充满SSR的内容新课程补充《弯曲细胞之谜2.0》（MCC 2.0）， 将无缝整合三个元素：CityLab 的课程故事情节和实验室经验、计算机 威斯康星大学河瀑布分校开发的分子生物学分析模拟以及沉浸式虚拟技术 加州大学伯克利分校创新基因组研究所开发的 SCD 疗法基因编辑的现实模拟。 SSR 将嵌入整个 MCC 2.0，对 STEM/生物医学科学职业的认识也将如此。 还将建立 NextGen Scholars，一个学习社区，不仅让学生参与先进科学 使用 SSR 的内容和实验室应用程序，同时也培养支持 STEM 公平和多样性的态度。 项目将证明这一教学策略的可行性和可复制性，然后城市实验室将进行传播； 广泛的课程，从而为未来多元化和包容性的 STEM 劳动力队伍播下种子。 拟议项目的主要目标是：（1）与高中教师合作创建MCC 2.0 和学生，(2) 建立一个多元化的学习者社区，使用 SSR 探索先进的科学主题 同时深入了解多样性、公平、包容性和社会正义在科学、健康和卫生领域的重要性 (3) 检查学生对科学内容的理解、SSR 技能、科学学习者身份的变化， 以及对生物医学科学和医学多样性的态度，(4) 通过以下方式跟踪学生参与者 大学了解这种方法的更广泛影响，并且（5）获得指定为第一批“高 符合下一代科学标准 (NGSS) 的“优质设计”高中课程。 SEPA 的这项新举措是试点、完善和传播首创科学教育的独特方式 该计划将增加 ​​STEM/生物医学科学劳动力的多样性。