One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia

蒙古人畜共患疾病研究健康创新奖学金

• 批准号: 9320856
• 负责人: Gregory Charles Gray
• 金额: $ 31.47万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-27 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9320856
• 关键词: Address; Advisory Committees; American; Animal Experimentation; Animals; Anthrax disease; Brucellosis; Budgets; Cattle; Certification; Collaborations; Complex; Country; Diagnostic; Disease; Economics; Environmental Engineering technology; Environmental Health; Epidemic; Ethics; Fellowship; Florida; Food Safety; Fostering; Funding; Goals; Goat; Government; Health; Health Professional; Health education; Hour; Human; Income; Influenza; Institution; Intervention; Mentors; Mining; Modeling; Modernization; Mongolia; Morbidity - disease rate; Nomads; Persons; Phase; Pilot Projects; Policies; Population; Postdoctoral Fellow; Prevention; Problem Solving; Process; Production; Public Health; Rabies; Research; Research Project Grants; Resources; Rickettsia Infections; Risk; Science; Sheep; Techniques; Technology; Trainers Training; Training; Training Programs; Translating; Travel; Universities; Zoonoses; burden of illness; disorder control; disorder prevention; environmental change; experience; global health; improved; infrastructure development; innovation; institutional capacity; laboratory facility; low and middle-income countries; member; multidisciplinary; novel; operation; programs; surveillance network; urban area

DESCRIPTION (provided by applicant): Responding to the Framework Programs for Global Health Innovation, this proposal builds upon an established US-Mongolia multidisciplinary partnership to address zoonotic disease burdens in Mongolia. In recent decades, Mongolia has experienced major economic and environmental changes, and suffered many large epidemics of zoonotic diseases. The long term goal of this submission is to develop a global health training program that elicits innovative, multidisciplinary team problem-solving solutions to develop products, alter disease processes, and guide policies in controlling zoonotic diseases in low- or middle- income countries. In this effort, we will employ One Health cross-disciplinary training and foster collaborations in public, veterinary, and environmental health sectors for one American and two Mongolian postdoctoral trainees per year (2-yr training period). These professionals will comprise a 3-person 'One Health' team that represents each of the three health sectors. Over the 5-yr period 4 such teams (12 postdoctoral fellows) will be engaged in zoonotic disease problem solving. In Phase I of the 2-yr period, teams will convene at the University of Florida (UF) for 2 months of training. They will receive 9 credit hours of One Health didactic training (Certificate in One Health) as well as training in ethical conduct of human and animal research. While in Florida, the postdoctoral teams will meet each week with a six- member Internal Advisory Committee (IAC, 4 US and 3 Mongolian members) who will pose zoonotic disease problems and guide them in engaging diverse expert groups at UF in developing a pilot research project and budget. While in Florida, the postdoctoral team will pitch their zoonotic disease problems and their ideas for projects to various professional groups at UF (e.g. animal science, food safety, environmental engineers, ecologists, geographers, as well as emerging disease, public health, and veterinary health professionals) with a goal of identifying innovative solutions to the problem and identifying UF and later Mongolian research mentors. During the last week of Phase I training, the postdoctoral team will present their project to the IAC for final approval and research fund release. The postdoctoral team will then travel to Mongolia and set up a research headquarters in the most appropriate Mongolian government collaborating institution, and move forward with pilot study execution. While the postdoctoral team will have at least weekly contact with their mentors and monthly contact with the IAC, this program will emphasize independent team problem solving by the postdoctoral fellows. Mongolia will greatly benefit from the implementation of a One Health research framework for global health innovation. Since moving to a market economy in 1992, Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing previously unconnected human and animal populations to new environmental terrains. For complex reasons, both humans and animals have suffered from increased zoonotic diseases, including brucellosis, anthrax, zoonotic influenza, rabies, and rickettsia diseases. Zoonotic diseases are both economic and health threats, as a large portion of the country's economy continue to rely upon animal production. Yet due to limited resources, Mongolia's health professionals have limited research and diagnostic capacity. There is a tremendous need for infrastructure development in the public, veterinary, and environmental health sectors, improved diagnostic laboratory facilities, stronger surveillance networks, and advanced One Health education to address complex zoonotic disease prevention and control strategies. This program will strengthen institutional capacity for innovative zoonotic disease training and research at both the University of Florida and at the multiple collaborating health institutions in Mongolia. It will also serve as a model program for similar interventions in other LMIC countries with zoonotic disease burdens. The specific aims of this project are to 1) identify the risks and conditions associated with zoonotic disease morbidity in Mongolia; 2) by employing modern technologies available at a large multidisciplinary US university and following a cross-disciplinary team approach, develop innovative One Health strategies to solve zoonotic disease problems in Mongolia; 3) following a train-the-trainer approach, transfer novel prevention and control techniques to regional public, animal, and environmental health professionals throughout Mongolia; and 4) translate scientific findings into prevention practices or products that will help to reduce the burden of zoonotic diseases among pastoral people worldwide.

描述（由申请人提供）：为了响应全球健康创新框架计划，该提案建立在美国-蒙古多学科伙伴关系的基础上，旨在解决蒙古的人畜共患疾病负担。近几十年来，蒙古国经历了重大的经济和环境变化，并遭受了多次大范围的人畜共患疾病流行。本次提交的长期目标是制定一项全球健康培训计划，以激发创新的多学科团队解决问题的解决方案，以开发产品、改变疾病过程并指导低收入或中等收入国家控制人畜共患疾病的政策。为此，我们将每年为一名美国博士后培训生和两名蒙古博士后培训生（培训期为 2 年）采用 One Health 跨学科培训，并促进公共、兽医和环境卫生领域的合作。这些专业人员将组成一个由 3 人组成的“One Health”团队，分别代表三个卫生部门。在 5 年期间，4 个这样的团队（12 名博士后研究员）将致力于解决人畜共患疾病问题。在两年期的第一阶段，各团队将齐聚佛罗里达大学 (UF) 进行为期 2 个月的训练。他们将获得 9 个 One Health 学分 教学培训（统一健康证书）以及人类和动物研究道德行为培训。在佛罗里达州期间，博士后团队每周将与六名成员的内部咨询委员会（IAC、4名美国成员和3名蒙古成员）会面，该委员会将提出人畜共患疾病问题，并指导他们与佛罗里达大学的不同专家组合作开展试点研究项目和预算。在佛罗里达州期间，博士后团队将向佛罗里达大学的各个专业团体（例如动物科学、食品安全、环境工程师、生态学家、地理学家，以及新出现的疾病、公共卫生和兽医）介绍他们的人畜共患疾病问题和项目想法。卫生专业人员），其目标是确定问题的创新解决方案，并确定佛罗里达大学和后来的蒙古研究导师。在第一阶段培训的最后一周，博士后团队将向IAC提交他们的项目以获得最终批准和研究基金发放。随后，博士后团队将前往蒙古国，在最合适的蒙古国政府合作机构设立研究总部，推进试点研究的执行。虽然博士后团队将至少每周与导师接触一次，每月与 IAC 接触一次，但该计划将强调博士后研究员独立团队解决问题的能力。蒙古将从全球卫生创新“同一个健康”研究框架的实施中受益匪浅。自 1992 年转向市场经济以来，蒙古经历了迅速的变化，采矿作业和绵羊、山羊和牛的动物生产增加。大部分通常游牧的牧民已经开始迁移到城市地区，并将以前没有联系的人类和动物种群引入新的环境地形。由于复杂的原因，人类和动物遭受的人畜共患病不断增加，包括布鲁氏菌病、炭疽病、人畜共患流感、狂犬病和立克次体病。人畜共患病对经济和健康都构成威胁，因为该国经济的很大一部分仍然依赖动物生产。然而，由于资源有限，蒙古卫生专业人员的研究和诊断能力有限。公共、兽医和环境卫生部门迫切需要发展基础设施、改进诊断实验室设施、更强大的监测网络和先进的“One Health”教育，以解决复杂的人畜共患疾病预防和控制战略。该计划将加强佛罗里达大学和蒙古多个合作卫生机构创新人畜共患疾病培训和研究的机构能力。它还将作为其他具有人畜共患疾病负担的中低收入国家类似干预措施的示范计划。该项目的具体目标是 1) 确定蒙古人畜共患疾病发病率相关的风险和条件； 2) 通过采用美国大型多学科大学现有的现代技术，并遵循跨学科团队的方法，制定创新的“同一个健康”战略来解决蒙古的人畜共患疾病问题； 3) 按照培训师培训方法，向蒙古各地的地区公共、动物和环境卫生专业人员传授新颖的预防和控制技术； 4) 将科学发现转化为预防实践或产品，有助于减轻全世界牧民人畜共患疾病的负担。

项目成果

One Health training, research, and outreach in North America.

一 北美的健康培训、研究和推广。

• 发表时间: 2016
• 作者: Stroud, Cheryl;Kaplan, Bruce;Logan, Jenae E;Gray, Gregory C
• 通讯作者: Gray, Gregory C

Distribution and molecular characteristics of rickettsiae found in ticks across Central Mongolia.

蒙古中部蜱中发现的立克次体的分布和分子特征。

• 发表时间: 2017-02-02
• 影响因子: 3.2
• 作者: Boldbaatar, Bazartseren;Jiang, Rui;von Fricken, Michael E;Lkhagvatseren, Sukhbaatar;Nymadawa, Pagbajab;Baigalmaa, Bekhochir;Wang, Ya;Anderson, Benjamin D;Jiang, Jia;Gray, Gregory C
• 通讯作者: Gray, Gregory C

Wide Distribution and Genetic Diversity of Babesia microti in Small Mammals from Yunnan Province, Southwestern China.

中国西南部云南省小型哺乳动物巴贝斯虫的广泛分布和遗传多样性。

• 发表时间: 2017-10
• 影响因子: 3.8
• 作者: Gao, Zi;Huang, Tao;Jiang, Bao;Jia, Na;Liu, Zheng;Shao, Zong;Jiang, Rui;Liu, Hong;Wei, Ran;Li, Yu;Yao, Hong;von Fricken, Michael E;Jiang, Jia;Du, Chun;Cao, Wu
• 通讯作者: Cao, Wu

Geographic Range of Lyme Borreliosis in Mongolia.

蒙古莱姆疏螺旋体病的地理范围。

• 发表时间: 2019
• 作者: von Fricken, Michael E;Rolomjav, Lkhunrev;Illar, Madeline;Altantogtokh, Doniddemberel;Hogan, Kathryn M;Uyanga, Baasandagva;Ganbold, Dalantai;Tsogbadrakh, Nyamdorj
• 通讯作者: Tsogbadrakh, Nyamdorj

A case series of fatal meningoencephalitis in Mongolia: epidemiological and molecular characteristics of tick-borne encephalitis virus.

蒙古致命性脑膜脑炎病例系列：蜱传脑炎病毒的流行病学和分子特征。

• 发表时间: 2019-01
• 作者: Baasandavga, Uyanga;Badrakh, Burmaajav;Burged, Natsagdorj;Davaajav, Otgonsuren;Khurelsukh, Tungalag;Barnes, Amber;Ulaankhuu, Unursaikhan;Nyamdorj, Tsogbadrakh
• 通讯作者: Nyamdorj, Tsogbadrakh