Accurate, Rapid Quantification of Cholesterol

准确、快速地定量胆固醇

• 批准号: 7171634
• 负责人: CRAIG A GRIMES
• 金额: $ 14.5万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171634
• 关键词: Accounting; Adult; Algorithms; Alloys; American; Arteries; Atherosclerosis; Behavior; Blood; Blood coagulation; Blood specimen; Cardiovascular Diseases; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Cholesterol; Classification; Clinic; Collection; Computer software; Computers; Condition; Coronary heart disease; Cost Savings; Coupled; Deposition; Detection; Development; Devices; Dextran Sulfate; Diagnostic; Electronics; Elements; Engineering; Environmental Monitoring; Equipment; Fatty acid glycerol esters; Figs - dietary; Frequencies; Goals; Hand; Health Personnel; Healthcare; Heart Diseases; High Density Lipoprotein Cholesterol; High Density Lipoproteins; Home environment; Indium; Individual; Left; Low-Density Lipoproteins; Magnetism; Measurement; Measures; Methods; Miniaturization; Monitor; Motivation; Operative Surgical Procedures; Population; Positioning Attribute; Precipitation; Price; Procedures; Process; Purpose; Reaction Time; Reader; Reading; Research; Research Personnel; Research Proposals; Right-On; Risk; Risk Factors; Schedule; Science; Secure; Shapes; Signal Transduction; Site; Solutions; Stroke; Surface; Syringes; System; Systems Integration; Technology; Testing; Translating; Travel; Triglycerides; United States; Venous; Very low density lipoprotein; Vision; Visit; Wireless Technology; Work; base; computerized data processing; concept; cost; day; design; desire; detector; disability; glucose monitor; improved; instrumentation; lipoprotein triglyceride; low density lipoprotein triglyceride; magnetic field; millimeter; monitoring device; patient home care; payment; prognostic; prototype; real world application; research study; response; sensor; size; statistics; vibration; voltage

DESCRIPTION (provided by applicant): Heart disease and stroke are the first and third leading causes of death in the United States, accounting for more than 40% of all deaths, or about 950,000 each year. Statistics have shown that about 61 million Americans, or one-fourth of the population, have some form of cardiovascular disease, which is a leading cause of premature, permanent disability among working adults. According to the Centers for Disease Control and Prevention, in 2003 the cost of heart disease and stroke was $351 billion; the major cause being deposition of fat and cholesterol at the artery wall (atherosclerosis). Many studies have demonstrated that high blood cholesterol is a major risk factor for coronary heart disease. It is the hypothesis, and motivation of this proposal that a method for accurately and simultaneously measuring the various cholesterol components via a system simple enough and low cost enough for home-care use would represent a significant improvement in health care. Currently, sophisticated cholesterol monitoring systems are quite expensive, while realistically affordable (less than $8000) homecare cholesterol monitors do not provide comprehensive results. This proposal seeks support for the underlying science and engineering necessary for development of a device that can rapidly, and accurately, quantify total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides that are commonly used to indicate the risk of developing coronary heart disease. The technology is based on the magnetoelastic sensor, a wireless, passive magnetism-based sensor platform made of a ribbon-shaped amorphous ferromagnetic alloy. When exposed to an excitation magnetic field, the sensor vibrates, generating a secondary magnetic flux that can be remotely detected with a magnetic coil. Since a mass load hinders the vibration of the sensor and alters its resonance frequency and amplitude, cholesterol monitoring can be realized by functionalizing the sensor with an absorbing coating that reacts to a cholesterol group, or using a solution that induces precipitation on the sensor surface when exposed to a particular cholesterol group. Specific objectives include {1} development of a sensor array that responds to LDL, total cholesterol and triglycerides; {2} development of a sensor reader for simultaneously monitoring multiple sensor elements, as well as an algorithm to translate sensor responses into LDL, HDL, total cholesterol and triglyceride levels; {3} design and prototype fabrication of a disposable cartridge that holds the sensor array.

描述（由申请人提供）：心脏病和中风是美国的第一和第三主要死亡原因，占所有死亡人数的40％以上，每年约为950,000。统计数据表明，大约有6100万美国人或人口的四分之一患有某种形式的心血管疾病，这是在职成年人中早产，永久残疾的主要原因。根据疾病控制与预防中心的数据，在2003年，心脏病和中风的成本为3510亿美元。主要原因是在动脉壁上脂肪和胆固醇的沉积（动脉粥样硬化）。许多研究表明，高血胆固醇是冠心病的主要危险因素。正是这一提议的假设和动机是，一种通过系统足够简单而低成本的系统来准确，同时测量各种胆固醇成分的方法将代表医疗保健的重大改善。目前，先进的胆固醇监测系统非常昂贵，而实际上负担得起（不到8000美元）的家庭胆固醇监测器并未提供全面的结果。该提案寻求支持开发可以快速，准确地量化总胆固醇，高密度脂蛋白（HDL），低密度脂蛋白（LDL）和甘油三酸酯的基础科学和工程的支持，这些设备通常用于表明发育中冠心心脏病的风险。该技术基于磁弹性传感器，该传感器是一种由丝带形的无定形非物质铁磁合金制成的无线，被动磁性的传感器平台。当暴露于激发磁场时，传感器会振动，产生二次磁通量，该磁通量可以用磁管远程检测。由于质量负荷会阻碍传感器的振动并改变其谐振频率和振幅，因此可以通过用吸收涂层功能使传感器功能化，从而实现胆固醇，或者使用对胆固醇组反应的吸收涂层，或者在暴露于特定的胆固醇基团时在传感器表面诱导沉淀的溶液。特定目标包括{1}的开发传感器阵列，该阵列对LDL，总胆固醇和甘油三酸酯做出了反应； {2}开发传感器读取器，用于同时监测多个传感器元件，以及将传感器响应转化为LDL，HDL，总胆固醇和甘油三酸酯水平的算法； {3}具有传感器阵列的一次性墨盒的设计和原型制造。