Assessment of Behavioral Deficits in Minipig Model of Pediatric Concussion

小型猪脑震荡模型行为缺陷的评估

基本信息

批准号：
10710194
负责人：
Alesa Hughson Netzley
金额：
$ 4.14万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2024-09-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10710194
关键词：
Adolescent Adult Age Anatomy Animal Model Animals Architecture Area Assessment tool Attention Autopsy Behavior Behavior assessment Behavioral Biological Biological Markers Brain Brain Concussion Brain Injuries Cause of Death Cell Transplantation Child Childhood Clinical Clinical Research Closed head injuries Cognition Craniocerebral Trauma Data Demyelinations Development Devices Diagnosis Diagnostic Diffuse Disease Domestic Pig Early identification Effectiveness Electrophysiology (science)Emergency department visit Exhibits Faculty Family suidae Functional Magnetic Resonance Imaging Functional disorder Future Goals Health Histologic Hour Human Imaging Techniques Impaired cognition Individual Injury Learning Long-Term Potentiation Magnetic Resonance Imaging Measures Mechanics Mental Depression Mentors Miniature Swine Modeling Molecular Natural regeneration Nervous System Trauma Neurocognitive Neurons Organism Patient Care Patient-Focused Outcomes Patients Phase Physiological Physiology Positioning Attribute Postdoctoral Fellow Procedures Public Health Publishing Rattus Recovery Rehabilitation therapy Reproducibility Research Research Personnel Rodent Rodent Model Sleep disturbances Stem cell transplant Structure Study models System TBI Patients Techniques Teenagers Therapeutic Tissues Training Translating Translational Research Trauma Traumatic Brain Injury United States Work behavior test bench to bedside biomarker identification care outcomes career clinically relevant cognitive function computerized data processing design disability efficacy validation experience head impact improved improved outcome interest member mild traumatic brain injury multimodality nerve injury nerve stem cell neural neuroimaging neuroinflammation nonhuman primate novel novel therapeutic intervention novel therapeutics pediatric patients porcine model post-doctoral training pre-clinical prognostication response sham surgery skills stroke model translational neuroscience transplantation therapy white matter

项目摘要

Project Summary/Abstract Traumatic brain injury (TBI) is a leading health concern for both children and adults worldwide. Similarities between pig and human brain anatomy, development, and neuroinflammatory response have brought attention to the domestic pig as a highly promising model animal for studying age-specific responses to mechanical trauma. To date, I have quantified baseline behavioral data in healthy Yucatan minipigs. For the duration of the training period, I will conduct a battery of behavioral tests to identify changes in behavior and physiology in juvenile pigs following a closed-head impact procedure designed to model pediatric concussion. In the postdoctoral phase, I plan to develop expertise in the development of novel neurointervention strategies in large animal models. To facilitate transition to a lab where I will need to utilize state-of-the-art imaging techniques to validate the efficacy of my treatments, I will use magnetic resonance imaging (MRI) as an assessment tool to quantify changes in neural structure and function in brain-injured pigs. I will receive comprehensive training in MRI data processing from experts in both human and pig neuroradiology. The proposed training plan is specifically crafted to prepare me, Alesa Netzley, for a fulfilling and distinguished career as a large animal systems and translational neuroscientist.

项目概要/摘要创伤性脑损伤 (TBI) 是全世界儿童和成人的主要健康问题。相似之处猪和人脑之间的解剖、发育和神经炎症反应引起了人们的关注家猪作为一种非常有前途的模型动物，用于研究年龄特异性对机械的反应创伤。迄今为止，我已经量化了健康尤卡坦小型猪的基线行为数据。在此期间在训练期间，我将进行一系列行为测试，以确定行为和生理的变化幼年猪接受了旨在模拟小儿脑震荡的闭头冲击程序。在博士后阶段，我计划在大规模开发新型神经干预策略方面发展专业知识动物模型。为了便于过渡到实验室，我需要利用最先进的成像技术来为了验证我的治疗效果，我将使用磁共振成像 (MRI) 作为评估工具量化脑损伤猪的神经结构和功能的变化。我将接受全面的培训来自人类和猪神经放射学专家的 MRI 数据处理。拟议的培训计划是专门为我，Alesa Netzley，为大型动物的充实而杰出的职业生涯做好准备系统和转化神经科学家。