Developmental Neurology

发育神经病学

• 批准号: 9385080
• 负责人: Thomas L. Schwarz
• 金额: $ 0.5万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9385080
• 关键词: Development; Neurology

 DESCRIPTION (provided by applicant): The Developmental Neurology Training Program at Boston Children's Hospital is designed to produce trainees who are equipped for and deeply engaged in state-of-the-art research in developmental neuroscience from a detailed and mechanistic perspective, while also cognizant of the clinical importance of their field and the clinical challenges and opportunities today. We take advantage of the presence of an extraordinary community of basic neuroscientists at Children's Hospital and its affiliated institutions, embedded in a world-class clinical setting. We select outstanding candidates who will work in one of 30 mentor laboratories and engage in fundamental research into the mechanisms that guide the development of the nervous system. These highly interactive laboratories employ genetics, molecular biology, biochemistry, electrophysiology, anatomy and behavior and use systems ranging from Drosophila to mouse, rat, and human cells. Consequently, our trainees are exposed to the full breadth of the field and are prepared to make informed strategic decisions. It is a special feature of this training program that each trainee wil be paired with a clinician or clinician-scientist as a co-mentor with the goal of helping trainees o understand the relationship of basic research to health and disease. This co-mentoring relationship will take advantage of the hospital setting and augment the rich opportunities for learning about translational research. The goal of the program is not to distract from an intensive research experience in fundamental molecular mechanisms of neurodevelopment, but rather to inform the trainee of its context in human health. The research experience of the trainee is also enhanced by an unusually extensive mentoring relationship with the Director of the Training Program, Prof. Thomas Schwarz, who meets with and advises all the trainees to offer feedback and career guidance. The training experience is also supplemented by a wealth of career-guidance instruction, including presentations skills, job- seeking skills, information about diverse career options, and of course the responsible conduct of research. All of this is situated within an environment of extraordinary resources and intellectual life. We have recruited a racially and ethnically diverse faculty of mentors and are committed to enhancing the diversity of the community of neuroscientists through our Training Program. The program thus seeks to enhance the experience of trainees beyond the opportunity to work with superb scientists tackling essential questions. There are few challenges in neuroscience as great as understanding the processes that result in neurodevelopmental disorders and intellectual disabilities and there is a growing awareness that many affective disorders arise from errors in development. Without deeper mechanistic understanding of these processes, the clinical challenges will remain. Training the next generation for this task is imperative.

 描述（由申请人提供）：波士顿儿童医院的发育神经病学培训计划旨在培养具备能力并从详细和机械的角度深入参与发育神经科学研究的受训人员，同时也认识到我们利用儿童医院及其附属机构的杰出基础神经科学家社区以及世界一流的临床环境，了解其领域的临床重要性以及当今的临床挑战和机遇。我们选择非常优秀的候选人，他们将在 30 个导师实验室之一工作，从事指导神经系统发育机制的基础研究，这些互动实验室采用遗传学、分子生物学、生物化学、电生理学、解剖学和行为以及使用系统。从果蝇到小鼠、大鼠和人类细胞，我们的学员都接触到了各个领域，并准备做出明智的战略决策，这是该培训计划的一个特点，每位学员都将与之配对。临床医生或临床医生科学家作为共同导师，旨在帮助学员了解基础研究与健康和疾病的关系。这种共同指导关系将利用医院环境并增加学习转化的丰富机会。该项目的目标不是分散对神经发育基本分子机制的深入研究经验，而是让受训者了解其在人类健康方面的背景。异常广泛的指导也增强了受训者的研究经验。与董事的关系培训计划中，Thomas Schwarz 教授会见所有学员并提供建议，提供反馈和职业指导。培训经验还辅以丰富的职业指导指导，包括演讲技巧、求职技巧、各种信息。职业选择，当然还有负责任的研究行为，所有这一切都建立在拥有非凡资源和智力生活的环境中。通过我们的培训因此，该计划旨在增强学员的经验，而不仅仅是与优秀科学家一起讨论基本问题的机会。在神经科学领域，很少有比了解导致神经发育障碍和智力障碍的过程更大的挑战了，而且人们的认识也在不断增强。如果对这些过程没有更深入的机械理解，许多情感障碍都是由发育错误引起的，因此培训下一代完成这项任务仍然是当务之急。