Arsenic Exposure and Skin Diseases in Bangladesh

孟加拉国的砷暴露与皮肤病

• 批准号: 6779939
• 负责人: David C Christiani
• 金额: $ 50.91万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6779939
• 关键词: Bangladesh; arsenic; biomarker; clinical research; diet; disease /disorder proneness /risk; dosage; environment related neoplasm /cancer; environmental exposure; environmental toxicology; epidemiology; genetic polymorphism; genetic susceptibility; human subject; lifestyle; metal poisoning; methylation; nutrition; nutrition related tag; skin derivative; skin disorder; skin neoplasms; urinalysis; water pollution; water supply

DESCRIPTION (provided by applicant): Arsenic is a carcinogen, a Superfund toxic compound, and a common drinking-water contaminant. The Environmental Protection Agency (EPA) has identified 1,300 sites on its National Priorities List (NPL) and arsenic has been found in at least 781 of these sites in the USA. Exposure may occur by a variety of pathways including inhalation of dusts in air, ingestion of contaminated soil or water, or through the food chain. The primary mode of exposure in non-occupationally exposed populations is drinking-water contamination from either alluvial deposits or industrial contamination. The precise relation of arsenic to cancer has not been established at low exposure levels. In addition, arsenic toxicokinetics in humans remains poorly understood. Thus, we propose to assess exposure and skin-lesion risk, as well as arsenic dosimetrics in a population with a wide range of arsenic exposure via drinking-water contamination. The proposal builds upon a small study in which a case-control study has been initiated. This proposal will use the necessary resources to analyze biomarkers of exposure and susceptibility and for statistical analyses of both a case-control study of skin lesions and a repeated-measures biomarker dosimetry study. The proposed studies in Bangladesh will assess this risk in a population with a wide range of exposures - from low to very high. Together, these data will add substantially to the existing risk assessment information by elucidating both early and late outcomes alter arsenic exposure, and the influence of susceptibility traits at all levels of exposure. This project is relevant to the overall aims of NIEHS in several ways: First, we will examine a range of health effects of an important environmental carcinogen. Second, we will define human biomarkers of exposure, early effects, and genetic susceptibility to arsenic exposure. Third, we will examine exposure-response relationships for arsenic-induced non-malignant skin lesions as well as for skin cancers.

描述（由申请人提供）：砷是一种致癌物，一种超级基金有毒 化合物和常见的饮用水污染物。环境保护 代理机构（EPA）在其国家优先级列表（NPL）上确定了1300个网站 在美国至少有781个地点发现了砷。接触 可能通过多种途径发生，包括吸入空气中的灰尘， 摄入受污染的土壤或水，或通过食物链。主要 非占地暴露种群的暴露方式是饮用水 冲积沉积或工业污染的污染。这 尚未在低暴露期间建立砷与癌症的精确关系 水平。此外，人类的砷毒性动物学仍然很差 理解。因此，我们建议评估暴露和皮肤质量风险 作为砷范围广泛的人群中的砷剂量测量法 通过饮用水污染。该提案建立在一项小型研究的基础上 在其中启动了一个病例对照研究。该提案将使用必要的资源来分析暴露和敏感性的生物标志物，以及对皮肤病变的病例对照研究和重复测量生物标志物的统计分析 剂量学研究。孟加拉国拟议的研究将在 从低到很高的人口范围很广。一起， 这些数据将大大增加现有风险评估信息 通过阐明早期和晚期结局改变了砷的暴露， 易感性特征在各个暴露水平上的影响。这个项目是 与NIEHS的整体目标相关以多种方式：首先，我们将研究一个 重要的环境致癌物的健康影响范围。第二，我们 将定义人类暴露，早期影响和遗传的生物标志物 对砷暴露的敏感性。第三，我们将检查曝光响应 砷诱导的非恶性皮肤病变的关系以及 皮肤癌。