Steroid influences on brain maturation

类固醇对大脑成熟的影响

• 批准号: 6837853
• 负责人: Julia L Zehr
• 金额: $ 4.73万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6837853
• 关键词: amygdala; animal developmental psychology; animal puberty; behavior test; behavioral /social science research tag; brain morphology; cues; dendrites; developmental neurobiology; hamsters; immunocytochemistry; male castration; neuroendocrine system; neurophysiology; neuropsychology; pheromone; postdoctoral investigator; preoptic areas; sex behavior; sex hormones; stereotaxic techniques; synapses; testosterone

DESCRIPTION (provided by applicant): Puberty is increasingly recognized as an important yet understudied period of brain maturation. Prepubertal and adult male hamsters differ in behavioral and physiological responses to chemosensory and hormonal stimuli, suggesting that a fundamental change in brain function occurs during puberty. This proposal tests the hypothesis that development of male sexual behavior during puberty results from neuroanatomical maturation of the forebrain mating circuit. Aim 1 tests whether pubertal changes in dendritic elaboration are associated with the pubertal development of male sexual behavior. The failure of prepubertal males to show sexual behavior with the appropriate chemosensory and hormonal priming also suggests that these signals may not be integrated and communicated within brain regions mediating sexual behavior. Aim 2 tests whether efferent and afferent neurons of Me are activated by chemosensory cues similarly in prepubertal and postpubertal males. A basic understanding of the processes controlling pubertal brain development provides a timely foundation for future studies of self-administered steroids, disease states, or environmental endocrine disrupters.

描述（由申请人提供）：青春期越来越多地被认为是一个重要但经过研究的脑部成熟时期。青春期前和成年雄性仓鼠在对化学感觉和荷尔蒙刺激的行为和生理反应方面有所不同，这表明脑功能的根本变化在青春期期间发生。该提案检验了以下假设：青春期期间男性性行为的发展是由前脑交配回路的神经解剖学成熟引起的。 AIM 1测试树突状阐述的青春期变化是否与男性性行为的青春期发展有关。青春期男性未通过适当的化学体和荷尔蒙启动表现出性行为的失败也表明，这些信号可能不会在介导性行为的大脑区域内整合和传达。 AIM 2测试ME的传出和传入神经元是否被化学感应线索激活，在青春期前和后假雄性中类似。对控制青春期脑发育的过程的基本理解为未来的自我管理类固醇，疾病状态或环境内分泌的研究为未来的研究提供了及时的基础。