A Case Control Study of Interstitial Cystitis

间质性膀胱炎病例对照研究

• 批准号: 6802355
• 负责人: JOHN W WARREN
• 金额: $ 64.49万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-18 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6802355
• 关键词: biomarker; clinical research; diagnosis design /evaluation; disease /disorder onset; disease /disorder proneness /risk; epidermal growth factor; human subject; interstitial cystitis; interview; irritable bowel syndrome; patient oriented research; prognosis; urinalysis; urinary tract disorder diagnosis

DESCRIPTION (provided by applicant): Interstitial cystitis (IC) is a chronic bladder disease manifested by severe bladder pain and urinary frequency and urgency. Using criteria established by the NIDDK, the diagnosis can be made by objective visible findings at cystoscopy. However, IC remains a disease of unknown etiology, inconvenient diagnosis, and unclear natural history. Women comprise 90% of IC cases for unknown reasons. Patients report less life satisfaction than those with end stage renal disease. Identification of risk factors is a proven method for providing clues to pathogenesis of a disease, yet a properly designed study of IC with incident cases, appropriate controls, and attention to disease onset date has never boon performed. Herein we propose such a study comprising national samples of incident IC cases and age and gender matched controls with rigorous attention to onset dates of symptoms. By telephone interview and medical record review, we will identify risk factors for IC and reveal non-bladder syndromes associated with IC. In this group of recent onset cases where a convenient diagnostic test would be most useful, we will test the utility of antiproliferative factor, a urinary factor discovered by Susan Keay of our group. We propose then to follow this well-investigated cohort of IC cases to initiate a natural history study of the disease. This project will allow us to test several hypotheses: 1. That certain features that precede onset of IC symptoms, e.g., bacterial cystitis, distinguish IC cases from controls matched for age and gender, and may be risk factors for the disease. 2) That patients with IC have higher prevalences of certain non-bladder syndromes, e.g., irritable bowel syndrome, than do matched controls. 3) That urine APF, HB-EGF, and/or EGF are sensitive and specific diagnostic markers for IC in patients with symptoms of <=12 months. 4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions.

描述（由申请人提供）：间质性膀胱炎（IC）是一种慢性膀胱疾病，表现为严重的膀胱疼痛，尿频和紧迫性。使用NIDDK建立的标准，可以通过膀胱镜检查中的客观可见发现进行诊断。但是，IC仍然是一种未知的病因，不便诊断和不清楚的自然史疾病。由于未知原因，妇女占IC病例的90％。患者报告的生活满意度比末期肾脏疾病患者少。 识别危险因素是为疾病发病机理提供线索的一种经过验证的方法，但是对IC进行了适当设计的IC研究，并从未进行过任何事件病例，适当的控制和对疾病发作日期的关注。在本文中，我们提出了一项研究，包括全国性的IC病例样本以及年龄和性别匹配的对照，并严格关注症状的发作日期。通过电话访谈和医疗记录审查，我们将确定IC的风险因素，并揭示与IC相关的非叶片综合征。在这组最有用的诊断测试的最新发病案例中，我们将测试抗增殖因子的实用性，抗增殖因子是我们小组的Susan Keay发现的泌尿因子。然后，我们建议遵循这种经过深入研究的IC病例的研究，以启动对该疾病的自然史研究。该项目将使我们能够检验几个假设： 1。在IC症状发作之前的某些特征，例如细菌性膀胱炎，将IC病例与年龄和性别相匹配的对照病例区分开，并且可能是该疾病的危险因素。 2）与匹配的对照相比，IC患者患有某些非狭窄综合征（例如肠易激综合征）的患病率更高。 3）尿液APF，HB-EGF和/或EGF对于症状<= 12个月的患者的IC敏感且特异性的诊断标记。 4）患有IC的患者有缓解，并且某些临床特征，例如疾病发作处细菌性膀胱炎，是预后的预后因素。