MECHANISMS OF NORMAL AND ABNORMAL CRANIOFACIAL MORPHOGEN

正常和异常颅面形态发生机制

• 批准号: 6708009
• 负责人: Jill Helms A Helms
• 金额: $ 7.87万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-15 至 2004-07-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6708009
• 关键词: antigen antibody reaction; biological signal transduction; chick embryo; congenital disorders; craniofacial; embryo /fetus; embryogenesis; gene expression; histogenesis; laboratory mouse; morphology; oral pharyngeal disorder; quail; retinoids; transcription factor; vertebrate embryology

My career objective is to investigate the genetic control of normal and abnormal craniofacial morphogenesis, My long-term goal is to use this knowledge of the prevention and treatment of craniofacial anomalies. To prepare for this career, I have received clinical training in Dentistry and Periodontology, and basic science training in Developmental Molecular Biology, Embryology and Neurosciences. This diverse educational background has provided me with the necessary scientific foundation to study the complex process of craniofacial development. I believe that the future of craniofacial development lies in understanding how to fully integrate the genetics and embryological processes of brain and head development. Therefore, in order to contribute in a substantial way to this area of research, I propose to expand my clinical training in the areas of Craniofacial Growth and Development, and extend my basic science education to induce advanced instruction in neuroanatomy, Neuroembryology, Biochemistry and mouse genetics. I am an Assistant Professor at UCSF since 1996. I hold a primary appointment in the School of Medicine and a joint appointment in the School of Dentistry. I am a member of two graduate programs, as well as clinical residents and fellows. Currently, I am the advisor to two graduate students and two post-doctoral fellows; I have also acted as the advisor to 8 dental, medical and graduate students as they undertook short-term research projects. My Advisory Committee is comprised of four senior scientists, each of whom is an internationally recognized expert in areas where my training is insufficient. They include Zena Werb, John Robenstein, Caroline Damsky and Karin Vargervik. These individuals have been deeply involved in mentoring me over the last three years. My interactions with these grant proposals (with Drs. Werb and Damsky), and numerous clinical and basic teaching opportunities (with Drs. Vargervik and Damsky). My research proposal focuses on the molecular regulation of craniofacial morphogenesis. We have identified tissues in the facial primordia that act as "organizers", similar to organizers in the limb and brain. Specifically, my research aims are to: 1) characterize the molecular signals that mediate this organizing activity in the face; 2) determine the functional role of these molecules in facial morphogenesis, and 3) gain an understanding of how perturbations in these signals produce the panoply of human craniofacial malformations ranging from cyclopia to facial duplications.

我的职业目标是研究对正常和异常颅面形态发生的遗传控制，我的长期目标是利用这种预防和治疗颅面异常的知识。为了为这一职业做准备，我接受了牙科和牙周病学的临床培训，以及发展性分子生物学，胚胎学和神经科学的基础科学培训。这种多样化的教育背景为我提供了研究颅面发展复杂过程的必要科学基础。我认为，颅面发展的未来在于理解如何完全整合大脑和头部发育的遗传学和胚胎学过程。因此，为了以实质性的方式为这一研究领域做出贡献，我建议在颅面生长和发展领域扩展我的临床培训，并扩展我的基础科学教育，以引起神经疾病，神经疾病，生物化学和小鼠的高级教学遗传学。我自1996年以来就一直是UCSF的助理教授。我在医学院任职，并在牙科学院任命联合任命。我是两个研究生课程以及临床居民和研究员的成员。目前，我是两名研究生和两个博士后研究员的顾问。我还担任8位牙科，医学和研究生的顾问，他们进行了短期研究项目。我的咨询委员会由四位高级科学家组成，每个科学家都是我培训不足的领域的国际认可的专家。其中包括Zena Werb，John Robenstein，Caroline Damsky和Karin Vargervik。在过去的三年中，这些人一直深入参与指导我。我与这些赠款提案（Werb和Damsky博士）以及许多临床和基本教学机会（与Vargervik和Damsky博士）进行了互动。我的研究建议着重于颅面形态发生的分子调节。我们已经确定了面部原基中的组织，这些组织是“组织者”的，类似于肢体和大脑中的组织者。具体而言，我的研究目的是：1）表征介导这种组织活动的分子信号； 2）确定这些分子在面部形态发生中的功能作用，以及3）了解这些信号中的扰动如何产生人类颅颅畸形的倾斜，范围从环岛到面部重复。