Mechanisms of Adjuvant Stimulation

辅助刺激机制

• 批准号: 6719064
• 负责人: Terry D. Connell
• 金额: $ 10.46万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6719064
• 关键词: Escherichia coli; antigen receptors; bacterial proteins; cell population study; chemical structure function; chimeric proteins; confocal scanning microscopy; drug delivery systems; enterotoxins; flow cytometry; gangliosides; immunocytochemistry; immunogenetics; immunologic substance development /preparation; immunomodulators; immunoregulation; immunotherapy; intermolecular interaction; laboratory mouse; leukocyte activation /transformation; lymphocyte; mucosal immunity; nonhuman therapy evaluation; pharmacokinetics; receptor coupling; vaccine development; Escherichia coli; antigen receptors; bacterial proteins; cell population study; chemical structure function; chimeric proteins; confocal scanning microscopy; drug delivery systems; enterotoxins; flow cytometry; gangliosides; immunocytochemistry; immunogenetics; immunologic substance development /preparation; immunomodulators; immunoregulation; immunotherapy; intermolecular interaction; laboratory mouse; leukocyte activation /transformation; lymphocyte; mucosal immunity; nonhuman therapy evaluation; pharmacokinetics; receptor coupling; vaccine development

The goals of this project are to study the immunomodulatory activities of LT-IIa and LT-IIb. Both toxins are potent mucosal adjuvants which elicit patterns of immune responses distinct from those elicited by cholera toxin. The toxins will be used as molecular tools to investigate the mechanisms that regulate adjuvant activity. We will engineer a new class of recombinant toxins to evaluate as potential mucosal vaccines.

该项目的目标是研究 LT-IIA和LT-IIB。两种毒素都是引起的有效粘膜佐剂 免疫反应的模式与霍乱毒素引起的反应不同。这 毒素将用作研究的分子工具来研究 调节辅助活动。我们将设计一种新的重组毒素 评估为潜在的粘膜疫苗。