Self-Monitored Physical Activity for Weight Management

用于体重管理的自我监测身体活动

• 批准号: 6737522
• 负责人: KAREN E WALKER
• 金额: $ 7.56万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6737522
• 关键词: African American; blood chemistry; blood glucose; blood lipid; blood pressure; body physical activity; clinical research; diet therapy; exercise; human middle age (35-64); human subject; interview; low socioeconomic status; nutrition related tag; obesity; patient oriented research; physical fitness; questionnaires; weight control; weight loss; young adult human (21-34)

DESCRIPTION (provided by applicant): This application for a Mentored Research Scientist Development Award (K01) is a re-submission by a new investigator. The goal of the award is to provide the investigator further training in the fields of obesity and community health nursing. As part of this training, the investigator will receive mentoring and pursue academic study in the following areas: 1) etiology and complications of obesity; 2) behavioral treatment of obesity; 3) community health nursing; 4) conduct of clinical trials; 5) exercise physiology; 6) biostatistics; and 7) nutrition. The proposal builds on a background in cardiovascular research, clinical study of weight loss maintenance, and community-based activities. Recent data show that 61% of US adults are overweight or obese. As a result, there is an epidemic of obesity-related health problems such as diabetes, coronary artery disease, and high blood pressure. Losses of only 5% to 10% of body weight significantly improve health, and individuals in programs that modify diet and lifestyle typically achieve weight losses of this magnitude. Unfortunately, the great majority of people cannot maintain the loss. Regular exercise is crucial to the maintenance of weight loss, but most individuals have problems with adherence due to a variety of barriers to exercise. Typical barriers are lack of time, lack of childcare, and lack of access to facilities. The goal of the proposed research is to improve the maintenance of weight loss by increasing physical activity in a low-income, primarily African American population that participates in a community-based behavioral weight loss program. All participants (n=152) will be treated with a 20-week weight reduction program followed by 52 weeks of maintenance. At the outset of the study, subjects will be randomized to one of two physical activity conditions. The research has two specific aims: The first is to compare at week 72 the maintenance of weight loss and physical activity adherence in individuals who are prescribed a standard structured exercise program of walking (Condition 1) versus a lifestyle activity intervention self-monitored via pedometer (Condition 2). Adherence will be determined by obtaining a common measure of physical activity across both conditions using accelerometers. The second aim is to compare short- (week 20) and long-term (week 72) differences between the two conditions in measures of physical (serum lipids, glucose/insulin ratio, interleukin-6, C-reactive protein, resting blood pressure, cardiorespiratory fitness) and psychosocial health (mood, quality of life). This study has been selected to further develop the investigator's knowledge of the treatment of obesity using principles of community health nursing, and the training has been designed to facilitate the investigator's development as an independent clinical scientist studying innovative ways of reducing cardiovascular risks within urban communities.

描述（由申请人提供）：这项指导研究科学家发展奖（K01）的申请是新调查员的重新提出。该奖项的目的是在肥胖症和社区健康护理领域为研究人员提供进一步的培训。作为这项培训的一部分，研究人员将在以下领域接受指导和进行学术研究：1）病因和肥胖的并发症； 2）肥胖的行为治疗； 3）社区健康护理； 4）进行临床试验； 5）运动生理； 6）生物统计学； 7）营养。该提案建立在心血管研究，减肥临床研究和基于社区活动的背景下。最近的数据表明，美国61％的成年人超重或肥胖。结果，存在与肥胖相关的健康问题的流行，例如糖尿病，冠状动脉疾病和高血压。只有5％至10％的体重的损失显着改善了健康，并且在改变饮食和生活方式的计划中，通常会实现这种规模的体重减轻。不幸的是，绝大多数人无法维持损失。定期运动对于维持体重减轻至关重要，但是由于各种运动障碍，大多数人都有依从性的问题。典型的障碍是缺乏时间，缺乏育儿和无法获得设施。拟议的研究的目的是通过增加低收入（主要是非裔美国人人口）的体育活动来改善体重减轻的维持，该活动主要参加基于社区的行为减肥计划。所有参与者（n = 152）将通过20周的减肥计划进行治疗，然后进行52周的维护。在研究开始时，受试者将被随机分为两个体育活动条件之一。这项研究具有两个具体的目的：第一个是在第72周进行比较，维持体重减轻和体育活动的遵守，那些处方的个人步行（条件1）与通过计步器自我监控（条件2）的生活方式活动干预措施相比。依从性将通过使用加速度计在两种情况下获得的体育活动的共同度量来确定。第二个目的是比较两种条件之间的短期（第20周）和长期（第72周）差异（血清脂质，葡萄糖/胰岛素比，白介素6，C-反应蛋白，静息蛋白，静止血压，心脏培训适应性）和心理社会健康（情绪，生活质量）。已选择这项研究是为了进一步发展研究者使用社区健康护理原则对肥胖治疗的了解，该培训旨在促进研究者的发展，作为一名独立的临床科学家，研究了降低城市社区中心血管风险的创新方式。