Peptide-based Star Polymers for Improved Biointeraction and Targeted Anticancer Therapies

基于肽的星形聚合物可改善生物相互作用和靶向抗癌治疗

• 批准号: DP140100002
• 负责人: Prof Greg Qiao
• 金额: $ 40.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140100002
• 关键词: Peptide; based; Star; Polymers; Improved

The aim of this project is to develop peptide-based star polymer nanocarriers for targeted drug delivery to cancer stem cells which integrate aptamer targeting technology and biointeraction studies with blood plasma fluid. The significance of this research is it pioneers the development of a drug delivery system that minimises plasma opsonization through understanding polymer-plasma interactions, which in turn increases tumour specificity and cell internalisation through incorporation of targeting aptamers and triggered drug release. This project will use rational design, advanced macromolecular engineering and an interdisciplinary collaboration to generate next-generation polymer therapeutics for drug delivery.

该项目的目的是开发基于肽的星形聚合物纳米载体，以将药物递送到癌症干细胞中，这些药物将适体靶向技术和生物互动研究与血浆液相结合。这项研究的意义在于，它是通过了解聚合物 - 血浆相互作用来最大程度地降低血浆调子化的药物递送系统的开发，从而通过掺入靶向适体并触发药物释放来增加肿瘤的特异性和细胞内在化。该项目将使用理性设计，高级大分子工程和跨学科的合作来生成下一代聚合物治疗药物以进行药物输送。