3D Surface Image Guided Therapy for Breast Irradiation

3D 表面图像引导乳腺照射治疗

• 批准号: 6788503
• 负责人: DEZHI LIU
• 金额: $ 10万
• 依托单位: GENEX TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6788503
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; breast neoplasms; charge coupled device camera; clinical biomedical equipment; computed axial tomography; image guided surgery /therapy; mammary gland; model design /development; neoplasm /cancer radiation therapy; phantom model

DESCRIPTION (provided by applicant): The primary objective of this SBIR program is to develop a novel 3D image guided adaptive therapy (3D IGAT) technique to improve the precision of radiation delivery during the course of Partial Breast Irradiation (PBI) treatment. We propose to perform patient repositioning and error correction based on accurate registration between the pre-operative CT scan and the 3D surface profiles of patient's breast acquired during the treatment. The 3D breast surface model will be acquired by a 3D surface imaging system to be designed and prototyped under this SBIR project. We will develop a deformable biomechanical finite-element breast model that establishes correlation between the 3D surface images and CT scans to derive the subsurface tumor location. Computational methods will be developed to estimate the true delivered dose given variations in patient geometry and to adaptively adjust he treatment plan when the delivered dose differs significantly from the planned dose with the aid of the finite element breast model.

描述（由申请人提供）： 该SBIR计划的主要目的是开发一种新型的3D图像引导的自适应疗法（3D IGAT）技术，以提高部分乳腺辐照过程（PBI）治疗过程中的辐射递送精度。我们建议根据术前CT扫描与患者乳房在治疗过程中获得的3D表面特征之间的准确配准进行患者重新定位和误差校正。 3D乳腺表面模型将由3D表面成像系统获取，该系统将在此SBIR项目下设计和原型。我们将开发一个可变形的生物力学有限元乳腺模型，该模型在3D表面图像和CT扫描之间建立相关性以推导地下肿瘤位置。将开发计算方法，以估算患者几何形状变化的真实剂量，并在借助有限的元素乳房模型的帮助下，与计划的剂量显着不同，以适应性地调整治疗计划。