Tracking Head Motion and Orientation in VOR Testing

VOR 测试中跟踪头部运动和方向

• 批准号: 6832690
• 负责人: B EUGENE PARKER
• 金额: $ 9.94万
• 依托单位: BARRON ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6832690
• 关键词: bioengineering /biomedical engineering; biomechanics; biomedical equipment development; biosensor device; biotechnology; clinical biomedical equipment; clinical research; computer data analysis; electromagnetic radiation; electrooculography; eye movements; head movements; human subject; magnetic field; neural information processing; neuropsychological tests; orientation; portable biomedical equipment; psychomotor function; sensorimotor system; vestibular apparatus; vestibuloocular reflex; visual tracking

The oculomotor response to angular head movement, or the angular vestibulo-ocular reflex (VOR), is a measure of the accuracy of communication between the inner ear and the eyes that has been demonstrated for head rotation in yaw, pitch, and roll. Current "high-frequency" VOR testing methods are insufficient because they fail to take into consideration the effect of otolithic coupling during off-axis head movements - i.e., in the case of not purely horizontal (yawing) or vertical (pitching) head movements. To enable these issues to be properly addressed, we herein propose development of a Kinematic Angular Vestibulo-Ocular Reflex Testing System (KAVORTS) that employs a three-dimensional (3-D) analysis of head motion and orientation during VOR testing in conjunction with the electrooculogram (EOG). Recent advances in the size and performance of micro-electromechanical systems (MEMS)-based inertial sensors enable the development of a device to provide precise information about head motion and orientation during VOR testing. The Phase I effort will also demonstrate - for the first time - computation of vertical eye asymmetry (bias) as a function of head motion, a capability that will facilitate the stratification of patients in terms of lesion location and progress of vestibular pathology.

动眼运动对角头运动的反应，或角性眼反射（VOR），是对内耳和眼睛之间通信准确性的度量，这些量度已证明是在偏航，俯仰和滚动中旋转的。当前的“高频” VOR测试方法不足，因为它们未能考虑到离轴头部运动过程中耳石耦合的影响 - 即，在不纯粹的水平（yaawing）或垂直（垂直（倾斜）头部）的情况下。为了使这些问题得到适当解决，我们在此提议开发运动角度的眼球 - 眼反射测试系统（KAVORTS），该系统通过与电击图（EOG）结合进行VOR测试期间对VOR测试过程中的头部运动和方向进行三维（3-D）分析。基于微电机电系统（MEMS）的惯性传感器的大小和性能的最新进展使设备能够开发在VOR测试期间提供有关头部运动和方向的精确信息。第一阶段的努力还将首次证明垂直眼睛不对称（偏置）随着头部运动的函数的计算，该功能将促进患者在病变位置和前庭病理的进展方面的分层。