International Workshop on Opportunistic Protists (IWOP-14)

机会性原生生物国际研讨会（IWOP-14）

基本信息

批准号：
9398434
负责人：
Melanie T Cushion
金额：
$ 0.5万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-08 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9398434
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Admission activity Adopted Africa South of the Sahara Amoeba genus Animal Model Animals Area Attention Basic Science Biological Response Modifier Therapy Blastocystis Candida Categories Cell Line Clinical Management Collaborations Communities Community Developments Conflict (Psychology)Consensus Country Cryptosporidium Culture Techniques Cyclospora Data Developed Countries Developing Countries Diagnostic Disease Educational workshop Environment Eukaryota Food Frequencies HIV Histoplasma Immune Immune system Immunologic Deficiency Syndromes In Vitro Individual International Literature Lower Organism Manipulative Therapies Methods Microbe Microbiology Microsporidia Minority Nomenclature Opportunistic Infections Organism Paper Parasites Parasitology Pathogenicity Pathology Patients Play Pneumocystis Pneumocystis carinii Pneumonia Policies Population Publications Publishing Reagent Recording of previous events Recruitment Activity Reporting Research Research Personnel Research Priority Role Schedule Scientific Societies Scientist Series Students Taxonomy Techniques Therapeutic immunosuppression Time Toxoplasma Toxoplasma gondii Transplantation United States United States Environmental Protection Agency Update Water Western Europe base biodefense career experience fungus genetic manipulation genome sequencing interest meetings microbial mortality pandemic disease pathogen symposium transmission process tumor necrosis factor-alpha inhibitor working group

项目摘要

This proposed R13 application covers the 14th meeting in a long standing series of the International Workshop on Opportunistic Protists (i.e. IWOP-14). These meeting are devoted to protists that cause serious problems in patients with defective immune systems, such as those receiving immunosuppressive therapies or with immune system debilitating diseases, such as AIDS. Many of these poorly understood pathogens were initially recognized due to their increased frequency in opportunistic settings, such as in HIV/AIDS and transplantation; however, it is now appreciated that these are also pathogens of immune competent hosts. Several of these organisms, due to their transmission by food and water, are also biodefense category B pathogens and environmental protection agency (EPA) pathogens of interest. The IWOP meeting was initiated in 1988 to serve the small, but growing international scientific community interested in working with the unusual, non-cultivatable organism Pneumocystis. At the time, Pneumocystis was relatively unknown and was ignored by many in the microbiological community. There was a need for a small meeting where scientists could exchange new techniques and experiences gained from working with these fastidious organisms. A basic tenet of the IWOP Workshops is a free exchange of information facilitated by open admission to the meeting. It has and is focused on students, trainees, young investigators and under-represented scientists. The 2nd through 11th IWOP meetings grew to include other OP-based community groups that experienced many of the research challenges facing the Pneumocystis community. The IWOP meetings now include research presentations on Cryptosporidia; Microsporidia; Toxoplasma gondii; and free-living amebae that are pathogenic. In recent years, IWOP has also begun serving as a forum for researchers of other eukaryotic microbial parasites that present pathologies in immune deficient individuals distinct from that observed in immune competent patients. Today, the IWOP meetings are regarded as critical meetings for most researchers investigating the basic science of Pneumocystis, Cryptosporidia, and Microsporidia. It is the meeting at which community based projects (e.g. genome sequencing, animal models, culture techniques, etc) and consensus papers (i.e. taxonomic status, research priorities, nomenclature standards) have been developed. Because many of these organisms are not well represented in larger fungal or parasitology meetings, research progress would clearly be severely hampered if this singular forum was no longer held. In comparison to other larger meetings these Workshops provide current updates that have not yet reached the literature.

拟议的 R13 申请涵盖了长期系列会议中的第 14 次会议国际机会原生生物研讨会（即 IWOP-14）。这些会议致力于对免疫系统有缺陷的患者造成严重问题的原生生物，例如接受免疫抑制治疗或患有免疫系统衰弱疾病，例如艾滋病。许多人们对这些知之甚少的病原体最初的认识是由于它们的机会主义环境中的频率增加，例如艾滋病毒/艾滋病和移植；然而，现在人们认识到这些也是具有免疫能力的宿主的病原体。其中一些生物体由于通过食物和水传播，也具有生物防御作用 B 类病原体和环境保护局 (EPA) 感兴趣的病原体。这 IWOP 会议于 1988 年发起，旨在为小型但不断发展的国际科学界提供服务。对处理不寻常的、不可培养的肺孢子菌感兴趣的社区。在当时，肺孢子虫相对不为人所知，并被微生物学界的许多人忽视。社区。需要召开一次小型会议，让科学家们可以交流新的知识从与这些挑剔的生物体一起工作中获得的技术和经验。一个基本原则 IWOP 研讨会的目的是通过公开入场促进信息的自由交流会议。它已经并将重点放在学生、实习生、年轻研究人员和代表性不足的人身上科学家。第 2 次至第 11 次 IWOP 会议逐渐扩大到包括其他基于 OP 的社区经历了肺孢子菌社区面临的许多研究挑战的小组。 IWOP 会议现在包括有关隐孢子虫的研究报告；微孢子虫；弓形虫；以及致病性的自由生活的阿米巴原虫。近年来，IWOP 还开始为其他真核微生物寄生虫的研究人员提供论坛免疫缺陷个体中存在的病理学与免疫缺陷个体中观察到的病理学不同有能力的患者。如今，IWOP 会议对于大多数人来说都被视为至关重要的会议。研究人员研究肺孢子虫、隐孢子虫和微孢子虫的基础科学。这是基于社区的项目（例如基因组测序、动物模型、培养技术等）和共识文件（即分类地位、研究重点、命名标准）已经制定。因为许多这些生物体都不好如果有代表参加更大型的真菌或寄生虫学会议，研究进展显然会受到影响如果不再举办这个独特的论坛，将会受到严重阻碍。与其他较大的相比这些研讨会提供了尚未达到文献的当前更新。